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    xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#"
    xmlns:owl="http://www.w3.org/2002/07/owl#"
    xmlns="http://mged.sourceforge.net/ontologies/MGEDOntology.owl#"
  xml:base="http://mged.sourceforge.net/ontologies/MGEDOntology.owl">
  <owl:Ontology rdf:about=""/>
  <owl:Class rdf:ID="BioAssayPackage">
    <rdfs:comment>MAGE package for bioassay.</rdfs:comment>
    <rdfs:label>BioAssayPackage</rdfs:label>
    <rdfs:subClassOf>
      <owl:Class rdf:about="#MGEDCoreOntology"/>
    </rdfs:subClassOf>
  </owl:Class>
  <owl:Class rdf:ID="OrganismPart">
    <rdfs:subClassOf>
      <owl:Class rdf:about="#OntologyEntry"/>
    </rdfs:subClassOf>
    <rdfs:comment>The part of the organism's anatomy from which the biomaterial was derived, excludes cells. E.g. tissue, organ, system, or body location (arm).</rdfs:comment>
    <rdfs:subClassOf>
      <owl:Class rdf:about="#BioMaterialCharacteristics"/>
    </rdfs:subClassOf>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:onProperty>
          <owl:ObjectProperty rdf:ID="has_database"/>
        </owl:onProperty>
        <owl:someValuesFrom>
          <owl:Class rdf:about="#OrganismPartDatabase"/>
        </owl:someValuesFrom>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:label>OrganismPart</rdfs:label>
  </owl:Class>
  <owl:Class rdf:ID="MethodologicalDesign">
    <rdfs:subClassOf>
      <owl:Class rdf:about="#ExperimentDesignType"/>
    </rdfs:subClassOf>
    <rdfs:label>MethodologicalDesign</rdfs:label>
    <rdfs:comment>A methodological experiment design type investigates differences caused by application of protocols, hardware, software and bioassay relationships, e.g quality control, replicates, loop.</rdfs:comment>
  </owl:Class>
  <owl:Class rdf:ID="Unit">
    <rdfs:label>Unit</rdfs:label>
    <rdfs:comment>Units of measure.</rdfs:comment>
    <rdfs:subClassOf>
      <owl:Class rdf:about="#MeasurementPackage"/>
    </rdfs:subClassOf>
  </owl:Class>
  <owl:Class rdf:ID="DistanceUnit">
    <rdfs:comment>Units used for distance measurements.</rdfs:comment>
    <rdfs:subClassOf rdf:resource="#Unit"/>
    <rdfs:label>DistanceUnit</rdfs:label>
  </owl:Class>
  <owl:Class rdf:ID="ChromosomalAberrationClassification">
    <rdfs:label>ChromosomalAberrationClassification</rdfs:label>
    <rdfs:subClassOf>
      <owl:Class rdf:about="#BioMaterialCharacteristics"/>
    </rdfs:subClassOf>
    <rdfs:comment>An irregularity in the number or structure of chromosomes, usually in the form of a gain (duplication), loss (deletion), exchange (translocation), or alteration in sequence (inversion) of genetic material. Excludes simple changes in sequence such as mutations, and is usually detectable by cytogenetic and microscopic techniques such as FISH.</rdfs:comment>
  </owl:Class>
  <owl:Class rdf:ID="BioMaterialCharacteristics">
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:someValuesFrom>
          <owl:Class rdf:about="#BibliographicReference"/>
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        <owl:onProperty>
          <owl:ObjectProperty rdf:ID="is_user_defined"/>
        </owl:onProperty>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:subClassOf>
      <owl:Class rdf:about="#BiologicalFactorCategory"/>
    </rdfs:subClassOf>
    <rdfs:label>BioMaterialCharacteristics</rdfs:label>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:someValuesFrom>
          <owl:Class rdf:about="#Contact"/>
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        <owl:onProperty rdf:resource="#is_user_defined"/>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:subClassOf>
      <owl:Class rdf:about="#BioMaterialPackage"/>
    </rdfs:subClassOf>
    <rdfs:comment>Properties of the biomaterial before treated in any manner for the purposes of the experiment.</rdfs:comment>
  </owl:Class>
  <owl:Class rdf:ID="StrandType">
    <rdfs:label>StrandType</rdfs:label>
    <rdfs:comment>A descriptor of the strand type the sequence feature belongs to. e.g. forward, reverse</rdfs:comment>
    <rdfs:subClassOf>
      <owl:Class rdf:about="#MGEDExtendedOntology"/>
    </rdfs:subClassOf>
  </owl:Class>
  <owl:Class rdf:ID="ClinicalTest">
    <rdfs:label>ClinicalTest</rdfs:label>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:someValuesFrom>
          <owl:Class rdf:about="#ClinicalTestType"/>
        </owl:someValuesFrom>
        <owl:onProperty>
          <owl:ObjectProperty rdf:ID="has_clinical_test_type"/>
        </owl:onProperty>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:subClassOf rdf:resource="#BioMaterialCharacteristics"/>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:someValuesFrom>
          <owl:Class rdf:about="#Measurement"/>
        </owl:someValuesFrom>
        <owl:onProperty>
          <owl:ObjectProperty rdf:ID="has_measurement"/>
        </owl:onProperty>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:comment></rdfs:comment>
  </owl:Class>
  <owl:Class rdf:ID="FeatureShape">
    <rdfs:comment>The expected shape of the feature on the array.</rdfs:comment>
    <rdfs:label>FeatureShape</rdfs:label>
    <rdfs:subClassOf>
      <owl:Class rdf:about="#ArrayDesignPackage"/>
    </rdfs:subClassOf>
  </owl:Class>
  <owl:Class rdf:ID="StrainOrLine">
    <rdfs:label>StrainOrLine</rdfs:label>
    <rdfs:comment>Animals or plants that have a single ancestral breeding pair or parent as a result of brother x sister or parent x offspring matings. </rdfs:comment>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:someValuesFrom>
          <owl:Class rdf:about="#StrainOrLineDatabase"/>
        </owl:someValuesFrom>
        <owl:onProperty rdf:resource="#has_database"/>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:subClassOf rdf:resource="#BioMaterialCharacteristics"/>
    <rdfs:subClassOf>
      <owl:Class rdf:about="#OntologyEntry"/>
    </rdfs:subClassOf>
  </owl:Class>
  <owl:Class rdf:ID="ExperimentalFactor">
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:someValuesFrom>
          <owl:Class rdf:about="#MethodologicalFactorCategory"/>
        </owl:someValuesFrom>
        <owl:onProperty>
          <owl:ObjectProperty rdf:ID="has_category"/>
        </owl:onProperty>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:someValuesFrom>
          <owl:Class rdf:about="#BiologicalFactorCategory"/>
        </owl:someValuesFrom>
        <owl:onProperty rdf:resource="#has_category"/>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:subClassOf>
      <owl:Class rdf:about="#ExperimentPackage"/>
    </rdfs:subClassOf>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:onProperty>
          <owl:ObjectProperty rdf:ID="has_factor_value"/>
        </owl:onProperty>
        <owl:someValuesFrom>
          <owl:Class rdf:about="#FactorValue"/>
        </owl:someValuesFrom>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:label>ExperimentalFactor</rdfs:label>
    <rdfs:comment>The factors in the study that are experimental parameters or regarded as influencing the experimental results.</rdfs:comment>
  </owl:Class>
  <owl:Class rdf:ID="MassUnitOther">
    <rdfs:label>MassUnitOther</rdfs:label>
    <rdfs:comment>Mass units not specified in MAGE.</rdfs:comment>
    <rdfs:subClassOf>
      <owl:Class rdf:about="#MassUnit"/>
    </rdfs:subClassOf>
  </owl:Class>
  <owl:Class rdf:ID="URI">
    <rdfs:label>URI</rdfs:label>
    <rdfs:subClassOf>
      <owl:Class rdf:ID="MGEDOntology"/>
    </rdfs:subClassOf>
    <rdfs:comment>Uniform Resource Identifier</rdfs:comment>
  </owl:Class>
  <owl:Class rdf:ID="LabelCompound">
    <rdfs:subClassOf>
      <owl:Class rdf:about="#Compound"/>
    </rdfs:subClassOf>
    <rdfs:label>LabelCompound</rdfs:label>
    <rdfs:comment>Compounds that are used for labeling extracts.</rdfs:comment>
  </owl:Class>
  <owl:Class rdf:ID="DesignElementGroupType">
    <rdfs:subClassOf>
      <owl:Class rdf:about="#ArrayDesignPackage"/>
    </rdfs:subClassOf>
    <rdfs:comment>Controlled set of descriptors for indicating the specific type of a Feature, Reporter, or CompositeSequence. </rdfs:comment>
    <rdfs:label>DesignElementGroupType</rdfs:label>
  </owl:Class>
  <owl:Class rdf:ID="DesignElementPackage">
    <rdfs:comment>The MAGE package for describing the elements located on the array.</rdfs:comment>
    <rdfs:label>DesignElementPackage</rdfs:label>
    <rdfs:subClassOf>
      <owl:Class rdf:about="#MGEDCoreOntology"/>
    </rdfs:subClassOf>
  </owl:Class>
  <owl:Class rdf:ID="DefectType">
    <rdfs:comment>Defects associated with features or zones such as those that are missing or moved. </rdfs:comment>
    <rdfs:subClassOf>
      <owl:Class rdf:about="#ArrayPackage"/>
    </rdfs:subClassOf>
    <rdfs:label>DefectType</rdfs:label>
  </owl:Class>
  <owl:Class rdf:ID="FiducialType">
    <rdfs:label>FiducialType</rdfs:label>
    <rdfs:subClassOf>
      <owl:Class rdf:about="#ArrayPackage"/>
    </rdfs:subClassOf>
    <rdfs:comment>A descriptor that indicates the type of the fiducial such as chrome border of an Affymetrix array or a laser ablation mark.</rdfs:comment>
  </owl:Class>
  <owl:Class rdf:ID="TechnologyType">
    <rdfs:subClassOf>
      <owl:Class rdf:about="#ArrayDesignPackage"/>
    </rdfs:subClassOf>
    <rdfs:comment>The technology type or platform of the reporters on the array.</rdfs:comment>
    <rdfs:label>TechnologyType</rdfs:label>
  </owl:Class>
  <owl:Class rdf:ID="Media">
    <rdfs:label>Media</rdfs:label>
    <rdfs:subClassOf>
      <owl:Class rdf:about="#GrowthCondition"/>
    </rdfs:subClassOf>
    <rdfs:comment>The physical state or matrix used to provide nutrients to the organism (e.g., liquid, agar, soil) .</rdfs:comment>
  </owl:Class>
  <owl:Class rdf:ID="PathogenTests">
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:onProperty>
          <owl:ObjectProperty rdf:ID="was_tested_for"/>
        </owl:onProperty>
        <owl:someValuesFrom>
          <owl:Class rdf:about="#Organism"/>
        </owl:someValuesFrom>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:someValuesFrom>
          <owl:Class>
            <owl:oneOf rdf:parseType="Collection">
              <owl:Thing rdf:ID="negative"/>
              <owl:Thing rdf:ID="inconclusive"/>
              <owl:Thing rdf:ID="positive"/>
            </owl:oneOf>
          </owl:Class>
        </owl:someValuesFrom>
        <owl:onProperty>
          <owl:ObjectProperty rdf:ID="has_result_summary"/>
        </owl:onProperty>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:comment>Tests and results for pathogens infecting organism from which the biosource is derived</rdfs:comment>
    <rdfs:subClassOf>
      <owl:Class rdf:about="#EnvironmentalHistory"/>
    </rdfs:subClassOf>
    <rdfs:label>PathogenTests</rdfs:label>
  </owl:Class>
  <owl:Class rdf:ID="Treatment">
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:someValuesFrom>
          <owl:Class rdf:about="#Action"/>
        </owl:someValuesFrom>
        <owl:onProperty>
          <owl:ObjectProperty rdf:ID="has_action"/>
        </owl:onProperty>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:comment>A treatment is the process or action by which a biomaterial is created from an input biomaterial.</rdfs:comment>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:onProperty>
          <owl:ObjectProperty rdf:ID="has_protocol"/>
        </owl:onProperty>
        <owl:someValuesFrom>
          <owl:Class rdf:about="#Protocol"/>
        </owl:someValuesFrom>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:label>Treatment</rdfs:label>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:someValuesFrom rdf:resource="http://www.w3.org/2001/XMLSchema#integer"/>
        <owl:onProperty>
          <owl:DatatypeProperty rdf:ID="has_order"/>
        </owl:onProperty>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:subClassOf>
      <owl:Class rdf:about="#BioMaterialPackage"/>
    </rdfs:subClassOf>
  </owl:Class>
  <owl:Class rdf:ID="Person">
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:onProperty>
          <owl:ObjectProperty rdf:ID="has_last_name"/>
        </owl:onProperty>
        <owl:someValuesFrom>
          <owl:Class rdf:about="http://www.w3.org/2002/07/owl#Thing"/>
        </owl:someValuesFrom>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:onProperty>
          <owl:ObjectProperty rdf:ID="has_mid_initials"/>
        </owl:onProperty>
        <owl:someValuesFrom rdf:resource="http://www.w3.org/2002/07/owl#Thing"/>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:someValuesFrom>
          <owl:Class rdf:about="#Organization"/>
        </owl:someValuesFrom>
        <owl:onProperty>
          <owl:ObjectProperty rdf:ID="has_affiliation"/>
        </owl:onProperty>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:subClassOf>
      <owl:Class rdf:about="#Contact"/>
    </rdfs:subClassOf>
    <rdfs:comment>The individual to contact regarding something provided such as a biomaterial.</rdfs:comment>
    <rdfs:label>Person</rdfs:label>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:someValuesFrom rdf:resource="http://www.w3.org/2002/07/owl#Thing"/>
        <owl:onProperty>
          <owl:ObjectProperty rdf:ID="has_first_name"/>
        </owl:onProperty>
      </owl:Restriction>
    </rdfs:subClassOf>
  </owl:Class>
  <owl:Class rdf:ID="SequenceOntologyBioSequenceType">
    <rdfs:subClassOf>
      <owl:Class rdf:about="#TheoreticalBioSequenceType"/>
    </rdfs:subClassOf>
    <rdfs:subClassOf>
      <owl:Class rdf:about="#PhysicalBioSequenceType"/>
    </rdfs:subClassOf>
    <rdfs:comment></rdfs:comment>
    <rdfs:label>SequenceOntologyBioSequenceType</rdfs:label>
    <rdfs:subClassOf>
      <owl:Class rdf:about="#OntologyEntry"/>
    </rdfs:subClassOf>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:onProperty rdf:resource="#has_database"/>
        <owl:someValuesFrom>
          <owl:Class rdf:about="#SequenceOntologyDatabase"/>
        </owl:someValuesFrom>
      </owl:Restriction>
    </rdfs:subClassOf>
  </owl:Class>
  <owl:Class rdf:ID="NormalizationDescriptionType">
    <rdfs:label>NormalizationDescriptionType</rdfs:label>
    <rdfs:subClassOf>
      <owl:Class rdf:about="#ExperimentPackage"/>
    </rdfs:subClassOf>
    <rdfs:comment>Controlled descriptors for the normalization strategy used for the experiment.</rdfs:comment>
  </owl:Class>
  <owl:Class rdf:ID="TumorGrading">
    <rdfs:subClassOf>
      <owl:Class rdf:about="#OntologyEntry"/>
    </rdfs:subClassOf>
    <rdfs:comment>A descriptor used in cancer biology to describe abnormalities of tumor cells. E.g. an instance from NCI Thesaurus. </rdfs:comment>
    <rdfs:subClassOf rdf:resource="#BioMaterialCharacteristics"/>
    <rdfs:label>TumorGrading</rdfs:label>
  </owl:Class>
  <owl:Class rdf:ID="Humidity">
    <rdfs:subClassOf>
      <owl:Class rdf:about="#GrowthCondition"/>
    </rdfs:subClassOf>
    <rdfs:label>Humidity</rdfs:label>
    <rdfs:comment>The humidity that the biosource is exposed to.</rdfs:comment>
  </owl:Class>
  <owl:Class rdf:ID="StrainOrLineDatabase">
    <rdfs:label>StrainOrLineDatabase</rdfs:label>
    <rdfs:subClassOf>
      <owl:Class rdf:about="#Database"/>
    </rdfs:subClassOf>
    <rdfs:comment>Database of strain, line, cultivar or ecotype information.</rdfs:comment>
  </owl:Class>
  <owl:Class rdf:ID="ExperimentPackage">
    <rdfs:label>ExperimentPackage</rdfs:label>
    <rdfs:comment>The descriptions associated with the Experiment package of MAGE</rdfs:comment>
    <rdfs:subClassOf>
      <owl:Class rdf:about="#MGEDCoreOntology"/>
    </rdfs:subClassOf>
  </owl:Class>
  <owl:Class rdf:ID="MaterialType">
    <rdfs:label>MaterialType</rdfs:label>
    <rdfs:subClassOf>
      <owl:Class rdf:about="#BioMaterialPackage"/>
    </rdfs:subClassOf>
    <rdfs:comment>Controlled terms for the state of the BioMaterial. Each state (BioSource, different BioSamples, and LabeledExtract) have MaterialTypes. Examples are population of an organism, organism, organism part, cell, etc.  </rdfs:comment>
  </owl:Class>
  <owl:Class rdf:ID="ArrayDesignPackage">
    <rdfs:subClassOf>
      <owl:Class rdf:about="#MGEDCoreOntology"/>
    </rdfs:subClassOf>
    <rdfs:comment>MAGE package that describes the array layout and design. The array may be physical or  virtual.</rdfs:comment>
    <rdfs:label>ArrayDesignPackage</rdfs:label>
  </owl:Class>
  <owl:Class rdf:ID="ArrayGroup">
    <rdfs:comment>An array group is a physical platform that contains one or more arrays that are separately addressable or a virtual grouping of arrays. </rdfs:comment>
    <rdfs:label>ArrayGroup</rdfs:label>
    <rdfs:subClassOf>
      <owl:Class rdf:about="#ArrayPackage"/>
    </rdfs:subClassOf>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:someValuesFrom>
          <owl:Class rdf:about="#Fiducial"/>
        </owl:someValuesFrom>
        <owl:onProperty>
          <owl:ObjectProperty rdf:ID="has_fiducials"/>
        </owl:onProperty>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:onProperty>
          <owl:ObjectProperty rdf:ID="has_type"/>
        </owl:onProperty>
        <owl:someValuesFrom>
          <owl:Class rdf:about="#SubstrateType"/>
        </owl:someValuesFrom>
      </owl:Restriction>
    </rdfs:subClassOf>
  </owl:Class>
  <owl:Class rdf:ID="GeographicLocationDatabase">
    <rdfs:label>GeographicLocationDatabase</rdfs:label>
    <rdfs:subClassOf>
      <owl:Class rdf:about="#Database"/>
    </rdfs:subClassOf>
    <rdfs:comment>Database of geographic locations.</rdfs:comment>
  </owl:Class>
  <owl:Class rdf:ID="FamilyRelationship">
    <rdfs:comment>A type of relationship applicable to mammals to describe the genetic relatedness of the individual under study.  E.g. brother or mother.</rdfs:comment>
    <rdfs:label>FamilyRelationship</rdfs:label>
    <rdfs:subClassOf>
      <owl:Class rdf:about="#BioMaterialPackage"/>
    </rdfs:subClassOf>
  </owl:Class>
  <owl:Class rdf:ID="DiseaseLocation">
    <rdfs:label>DiseaseLocation</rdfs:label>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:someValuesFrom>
          <owl:Class>
            <owl:oneOf rdf:parseType="Collection">
              <owl:Thing rdf:ID="metastatic_site"/>
              <owl:Thing rdf:ID="primary_site"/>
            </owl:oneOf>
          </owl:Class>
        </owl:someValuesFrom>
        <owl:onProperty>
          <owl:ObjectProperty rdf:ID="has_cancer_site"/>
        </owl:onProperty>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:comment>Anatomical location(s) of disease.</rdfs:comment>
    <rdfs:subClassOf rdf:resource="#OrganismPart"/>
  </owl:Class>
  <owl:Class rdf:ID="OperatorVariation">
    <rdfs:subClassOf>
      <owl:Class rdf:about="#MethodologicalFactorCategory"/>
    </rdfs:subClassOf>
    <rdfs:comment>The effects of different investigators, laboratories, or organizations on experimental results are studied.</rdfs:comment>
    <rdfs:label>OperatorVariation</rdfs:label>
  </owl:Class>
  <owl:Class rdf:ID="BioAssayData">
    <rdfs:subClassOf>
      <owl:Class rdf:about="#BioAssayDataPackage"/>
    </rdfs:subClassOf>
    <rdfs:label>BioAssayData</rdfs:label>
    <rdfs:comment>BioAssayData refers to the data files including images generated from one or more BioAssays.</rdfs:comment>
  </owl:Class>
  <owl:Class rdf:ID="WarningType">
    <rdfs:label>WarningType</rdfs:label>
    <rdfs:comment>Controlled terms for descriptors of the warnings associated with reporters.</rdfs:comment>
    <rdfs:subClassOf rdf:resource="#DesignElementPackage"/>
  </owl:Class>
  <owl:Class rdf:ID="LaboratoryTestDatabase">
    <rdfs:comment>Database of codes for clinical findings.</rdfs:comment>
    <rdfs:label>LaboratoryTestDatabase</rdfs:label>
    <rdfs:subClassOf>
      <owl:Class rdf:about="#Database"/>
    </rdfs:subClassOf>
  </owl:Class>
  <owl:Class rdf:ID="TheoreticalBioSequenceType">
    <rdfs:label>TheoreticalBioSequenceType</rdfs:label>
    <rdfs:comment>A theoretical biosequence type is an abstraction used for annotation design of elements, e.g. gene, intron.</rdfs:comment>
    <rdfs:subClassOf>
      <owl:Class rdf:about="#BioSequenceType"/>
    </rdfs:subClassOf>
  </owl:Class>
  <owl:Class rdf:ID="SomaticModification">
    <rdfs:comment>The organism has had non-genetic parts removed, added, or rearranged.</rdfs:comment>
    <rdfs:label>SomaticModification</rdfs:label>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:someValuesFrom rdf:resource="#OrganismPart"/>
        <owl:onProperty>
          <owl:ObjectProperty rdf:ID="has_part_modified"/>
        </owl:onProperty>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:subClassOf>
      <owl:Class rdf:about="#MGEDExtendedOntology"/>
    </rdfs:subClassOf>
  </owl:Class>
  <owl:Class rdf:ID="TargetedCellTypeDatabase">
    <rdfs:label>TargetedCellTypeDatabase</rdfs:label>
    <rdfs:comment>Database of targeted cell type information.</rdfs:comment>
    <rdfs:subClassOf>
      <owl:Class rdf:about="#Database"/>
    </rdfs:subClassOf>
  </owl:Class>
  <owl:Class rdf:ID="PopulationDensity">
    <rdfs:comment>The concentration range of the organism.</rdfs:comment>
    <rdfs:label>PopulationDensity</rdfs:label>
    <rdfs:subClassOf>
      <owl:Class rdf:about="#GrowthCondition"/>
    </rdfs:subClassOf>
  </owl:Class>
  <owl:Class rdf:ID="TemperatureUnit">
    <rdfs:label>TemperatureUnit</rdfs:label>
    <rdfs:subClassOf rdf:resource="#Unit"/>
    <rdfs:comment>Units used for temperature measurements.</rdfs:comment>
  </owl:Class>
  <owl:Class rdf:ID="CellLine">
    <rdfs:comment>The identifier for the cell line if one was used as a biomaterial. </rdfs:comment>
    <rdfs:subClassOf rdf:resource="#BioMaterialCharacteristics"/>
    <rdfs:label>CellLine</rdfs:label>
    <rdfs:subClassOf>
      <owl:Class rdf:about="#OntologyEntry"/>
    </rdfs:subClassOf>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:someValuesFrom>
          <owl:Class rdf:about="#CellLineDatabase"/>
        </owl:someValuesFrom>
        <owl:onProperty rdf:resource="#has_database"/>
      </owl:Restriction>
    </rdfs:subClassOf>
  </owl:Class>
  <owl:Class rdf:ID="ControlType">
    <rdfs:comment>Controlled terms for descriptors for the type of control design element.</rdfs:comment>
    <rdfs:subClassOf rdf:resource="#DesignElementPackage"/>
    <rdfs:label>ControlType</rdfs:label>
  </owl:Class>
  <owl:Class rdf:ID="Genotype">
    <rdfs:comment>The total sum of the genetic information of an organism that is known and relevant to the experiment being performed.</rdfs:comment>
    <rdfs:label>Genotype</rdfs:label>
    <rdfs:subClassOf>
      <owl:Class rdf:about="#IndividualGeneticCharacteristics"/>
    </rdfs:subClassOf>
  </owl:Class>
  <owl:Class rdf:ID="ReplicateDescriptionType">
    <rdfs:comment>Controlled descriptors for the type of replication.</rdfs:comment>
    <rdfs:subClassOf rdf:resource="#ExperimentPackage"/>
    <rdfs:label>ReplicateDescriptionType</rdfs:label>
  </owl:Class>
  <owl:Class rdf:ID="FeatureGroup">
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:onProperty>
          <owl:ObjectProperty rdf:ID="has_feature_shape"/>
        </owl:onProperty>
        <owl:someValuesFrom rdf:resource="#FeatureShape"/>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:comment>Technology-based grouping of features representing individual locations on the array. </rdfs:comment>
    <rdfs:label>FeatureGroup</rdfs:label>
    <rdfs:subClassOf rdf:resource="#ArrayDesignPackage"/>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:someValuesFrom rdf:resource="#TechnologyType"/>
        <owl:onProperty rdf:resource="#has_type"/>
      </owl:Restriction>
    </rdfs:subClassOf>
  </owl:Class>
  <owl:Class rdf:ID="EnvironmentalHistory">
    <rdfs:label>EnvironmentalHistory</rdfs:label>
    <rdfs:subClassOf rdf:resource="#BioMaterialCharacteristics"/>
    <rdfs:comment>A description of the conditions the organism has been exposed to that are not one of the variables under study. </rdfs:comment>
  </owl:Class>
  <owl:Class rdf:ID="BioAssay">
    <rdfs:subClassOf rdf:resource="#BioAssayPackage"/>
    <rdfs:comment>A bioassay is an abstract class representing physical and computational groupings of biomaterials and arrays.</rdfs:comment>
    <rdfs:label>BioAssay</rdfs:label>
  </owl:Class>
  <owl:Class rdf:ID="MGEDCoreOntology">
    <rdfs:subClassOf rdf:resource="#MGEDOntology"/>
    <rdfs:comment>An ontology developed by the Microarray Gene Expression Data (MGED) Society to provide descriptors required for MAGE v.1 documents. </rdfs:comment>
    <rdfs:label>MGEDCoreOntology</rdfs:label>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:someValuesFrom rdf:resource="http://www.w3.org/2002/07/owl#Thing"/>
        <owl:onProperty>
          <owl:ObjectProperty rdf:ID="has_ID"/>
        </owl:onProperty>
      </owl:Restriction>
    </rdfs:subClassOf>
  </owl:Class>
  <owl:Class rdf:ID="Allele">
    <rdfs:subClassOf>
      <owl:Class rdf:about="#IndividualGeneticCharacteristics"/>
    </rdfs:subClassOf>
    <rdfs:comment>One of two or more alternative forms of a gene or marker sequence and differing from other alleles at one or more mutational sites based on phenotype or sequence. Polymorphisms are included in this definition.</rdfs:comment>
    <rdfs:label>Allele</rdfs:label>
  </owl:Class>
  <owl:Class rdf:ID="FamilyHistory">
    <rdfs:comment>Relevant aspects of genetic preconditions or family member's clinical history.</rdfs:comment>
    <rdfs:label>FamilyHistory</rdfs:label>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:someValuesFrom>
          <owl:Class rdf:about="#FamilyMember"/>
        </owl:someValuesFrom>
        <owl:onProperty>
          <owl:ObjectProperty rdf:ID="has_family_member"/>
        </owl:onProperty>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:subClassOf rdf:resource="#EnvironmentalHistory"/>
  </owl:Class>
  <owl:Class rdf:ID="Light">
    <rdfs:subClassOf>
      <owl:Class rdf:about="#GrowthCondition"/>
    </rdfs:subClassOf>
    <rdfs:comment>The photoperiod and type (e.g., natural, restricted wavelength) of light exposure. </rdfs:comment>
    <rdfs:label>Light</rdfs:label>
  </owl:Class>
  <owl:Class rdf:ID="ConcentrationUnit">
    <rdfs:comment>Units used for concentration measurements.</rdfs:comment>
    <rdfs:subClassOf rdf:resource="#Unit"/>
    <rdfs:label>ConcentrationUnit</rdfs:label>
  </owl:Class>
  <owl:Class rdf:ID="User">
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:onProperty rdf:resource="#has_ID"/>
        <owl:someValuesFrom rdf:resource="http://www.w3.org/2002/07/owl#Thing"/>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:subClassOf>
      <owl:Class rdf:about="#MGEDExtendedOntology"/>
    </rdfs:subClassOf>
    <rdfs:comment>User is a way to id a person in a database</rdfs:comment>
    <rdfs:label>User</rdfs:label>
  </owl:Class>
  <owl:Class rdf:ID="ProtocolPackage">
    <rdfs:label>ProtocolPackage</rdfs:label>
    <rdfs:subClassOf rdf:resource="#MGEDCoreOntology"/>
    <rdfs:comment>The MAGE package for protocols.</rdfs:comment>
  </owl:Class>
  <owl:Class rdf:ID="OrganismDatabase">
    <rdfs:subClassOf>
      <owl:Class rdf:about="#Database"/>
    </rdfs:subClassOf>
    <rdfs:label>OrganismDatabase</rdfs:label>
    <rdfs:comment>Database of taxonomic information.</rdfs:comment>
  </owl:Class>
  <owl:Class rdf:ID="IndividualGeneticCharacteristics">
    <rdfs:subClassOf rdf:resource="#BioMaterialCharacteristics"/>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:onProperty>
          <owl:ObjectProperty rdf:about="#has_value"/>
        </owl:onProperty>
        <owl:someValuesFrom rdf:resource="http://www.w3.org/2002/07/owl#Thing"/>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:comment>The genotype of the individual organism from which the biomaterial was derived. Individual genetic characteristics include polymorphisms, disease alleles, and haplotypes. </rdfs:comment>
    <rdfs:label>IndividualGeneticCharacteristics</rdfs:label>
  </owl:Class>
  <owl:Class rdf:ID="QuantitationType">
    <rdfs:subClassOf>
      <owl:Class rdf:about="#QuantitationTypePackage"/>
    </rdfs:subClassOf>
    <rdfs:comment>The QuantitationType provides a method for calculating a single datum of the BioAssayData matrix.</rdfs:comment>
    <rdfs:label>QuantitationType</rdfs:label>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:someValuesFrom>
          <owl:Class rdf:about="#DataType"/>
        </owl:someValuesFrom>
        <owl:onProperty rdf:resource="#has_type"/>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:onProperty>
          <owl:ObjectProperty rdf:ID="has_scale"/>
        </owl:onProperty>
        <owl:someValuesFrom>
          <owl:Class rdf:about="#Scale"/>
        </owl:someValuesFrom>
      </owl:Restriction>
    </rdfs:subClassOf>
  </owl:Class>
  <owl:Class rdf:ID="AtomicAction">
    <rdfs:subClassOf>
      <owl:Class rdf:about="#Action"/>
    </rdfs:subClassOf>
    <rdfs:comment>An atomic action  is a single step process on the biomaterial, e.g mix by inversion, wait, add</rdfs:comment>
    <rdfs:label>AtomicAction</rdfs:label>
  </owl:Class>
  <owl:Class rdf:ID="ClinicalTreatment">
    <rdfs:subClassOf>
      <owl:Class rdf:about="#OntologyEntry"/>
    </rdfs:subClassOf>
    <rdfs:label>ClinicalTreatment</rdfs:label>
    <rdfs:comment>The current clinical treatment(s) of the patient from which the biosource is derived.</rdfs:comment>
    <rdfs:subClassOf rdf:resource="#BioMaterialCharacteristics"/>
  </owl:Class>
  <owl:Class rdf:ID="Compound">
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:someValuesFrom>
          <owl:Class>
            <owl:oneOf rdf:parseType="Collection">
              <owl:Thing rdf:ID="no"/>
              <owl:Thing rdf:ID="yes"/>
            </owl:oneOf>
          </owl:Class>
        </owl:someValuesFrom>
        <owl:onProperty>
          <owl:ObjectProperty rdf:ID="is_solvent"/>
        </owl:onProperty>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:subClassOf>
      <owl:Class rdf:about="#BiologicalFactorCategory"/>
    </rdfs:subClassOf>
    <rdfs:comment>A drug, solvent, chemical, etc., with a property that can be measured such as concentration.</rdfs:comment>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:onProperty rdf:resource="#has_database"/>
        <owl:someValuesFrom>
          <owl:Class rdf:about="#CompoundDatabase"/>
        </owl:someValuesFrom>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:subClassOf>
      <owl:Class rdf:about="#OntologyEntry"/>
    </rdfs:subClassOf>
    <rdfs:label>Compound</rdfs:label>
  </owl:Class>
  <owl:Class rdf:ID="Ecotype">
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:someValuesFrom rdf:resource="#StrainOrLineDatabase"/>
        <owl:onProperty rdf:resource="#has_database"/>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:subClassOf rdf:resource="#StrainOrLine"/>
    <rdfs:comment>a biotype resulting from selection in a particular habitat, e.g. the A.thaliana Ecotype Ler</rdfs:comment>
    <rdfs:label>Ecotype</rdfs:label>
  </owl:Class>
  <owl:Class rdf:ID="Node">
    <rdfs:subClassOf>
      <owl:Class rdf:about="#HigherLevelAnalysisPackage"/>
    </rdfs:subClassOf>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:onProperty>
          <owl:ObjectProperty rdf:ID="has_node_value"/>
        </owl:onProperty>
        <owl:someValuesFrom>
          <owl:Class rdf:about="#NodeValue"/>
        </owl:someValuesFrom>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:label>Node</rdfs:label>
    <rdfs:comment>A node is an individual component of BioAssayDataCluster that groups design elements, quantitation types, and BioAssays together. A node may contain other nodes.</rdfs:comment>
  </owl:Class>
  <owl:Class rdf:ID="Reporter">
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:someValuesFrom rdf:resource="#WarningType"/>
        <owl:onProperty rdf:resource="#has_type"/>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:comment>Description of the material placed on a feature (spot).</rdfs:comment>
    <rdfs:subClassOf>
      <owl:Class rdf:about="#DesignElement"/>
    </rdfs:subClassOf>
    <rdfs:label>Reporter</rdfs:label>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:someValuesFrom>
          <owl:Class rdf:about="#FailType"/>
        </owl:someValuesFrom>
        <owl:onProperty rdf:resource="#has_type"/>
      </owl:Restriction>
    </rdfs:subClassOf>
  </owl:Class>
  <owl:Class rdf:ID="BioSource">
    <rdfs:label>BioSource</rdfs:label>
    <rdfs:comment>The BioSource is the original source material before any treatment events. </rdfs:comment>
    <rdfs:subClassOf>
      <owl:Class rdf:about="#BioMaterial"/>
    </rdfs:subClassOf>
  </owl:Class>
  <owl:Class rdf:ID="ChromosomalAberration">
    <rdfs:label>ChromosomalAberration</rdfs:label>
    <rdfs:subClassOf rdf:resource="#IndividualGeneticCharacteristics"/>
    <rdfs:subClassOf>
      <owl:Class rdf:about="#OntologyEntry"/>
    </rdfs:subClassOf>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:someValuesFrom>
          <owl:Class rdf:about="#ChromosomalAberrationDatabase"/>
        </owl:someValuesFrom>
        <owl:onProperty rdf:resource="#has_database"/>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:comment>An abnormality of a chromosome's number or structure, which excludes simple changes in sequence and is usually detectable by cytogentic and microscopic techniques such as FISH.</rdfs:comment>
  </owl:Class>
  <owl:Class rdf:ID="SubstrateType">
    <rdfs:label>SubstrateType</rdfs:label>
    <rdfs:comment>Controlled terms for descriptors of types of array substrates.</rdfs:comment>
    <rdfs:subClassOf>
      <owl:Class rdf:about="#ArrayPackage"/>
    </rdfs:subClassOf>
  </owl:Class>
  <owl:Class rdf:ID="InitialTimePoint">
    <rdfs:label>InitialTimePoint</rdfs:label>
    <rdfs:subClassOf>
      <owl:Class rdf:about="#BioMaterialPackage"/>
    </rdfs:subClassOf>
    <rdfs:comment>The point from which measurements of age were taken.</rdfs:comment>
  </owl:Class>
  <owl:Class rdf:ID="HardwareVariation">
    <rdfs:label>HardwareVariation</rdfs:label>
    <rdfs:comment>The effects of different hardware, types of hardware, or models of hardware on experimental results are studied.</rdfs:comment>
    <rdfs:subClassOf>
      <owl:Class rdf:about="#MethodologicalFactorCategory"/>
    </rdfs:subClassOf>
  </owl:Class>
  <owl:Class rdf:ID="HistoryFactor">
    <rdfs:subClassOf>
      <owl:Class rdf:about="#MGEDExtendedOntology"/>
    </rdfs:subClassOf>
    <rdfs:label>HistoryFactor</rdfs:label>
    <rdfs:comment>Factors that are measured or observed parts of the study but not induced or under the control of the experiment. These factors do not have protocols (e.g., epidemiology factors).</rdfs:comment>
  </owl:Class>
  <owl:Class rdf:ID="SequenceOntologyDatabase">
    <rdfs:subClassOf>
      <owl:Class rdf:about="#Database"/>
    </rdfs:subClassOf>
    <rdfs:comment>Database for sequence annotation information.</rdfs:comment>
    <rdfs:label>SequenceOntologyDatabase</rdfs:label>
  </owl:Class>
  <owl:Class rdf:ID="OrganismStatus">
    <rdfs:label>OrganismStatus</rdfs:label>
    <rdfs:subClassOf rdf:resource="#BioMaterialCharacteristics"/>
    <rdfs:comment>The stage premortem or postmortem at which the sample was processed for extraction of biomaterials. </rdfs:comment>
  </owl:Class>
  <owl:Class rdf:ID="MethodologicalFactorCategory">
    <rdfs:comment>The effects on results of changing protocols, hardware, software, or people performing the experiments are studied Examples are comparison of data across different labeling protocols, scanners, image quantification software, or laboratories. </rdfs:comment>
    <rdfs:subClassOf>
      <owl:Class rdf:about="#ExperimentalFactorCategory"/>
    </rdfs:subClassOf>
    <rdfs:label>MethodologicalFactorCategory</rdfs:label>
  </owl:Class>
  <owl:Class rdf:ID="ConcentrationUnitOther">
    <rdfs:subClassOf rdf:resource="#ConcentrationUnit"/>
    <rdfs:comment>Concentration units not specified in MAGE.</rdfs:comment>
    <rdfs:label>ConcentrationUnitOther</rdfs:label>
  </owl:Class>
  <owl:Class rdf:ID="OntologyEntry">
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:onProperty>
          <owl:DatatypeProperty rdf:ID="has_description"/>
        </owl:onProperty>
        <owl:someValuesFrom rdf:resource="http://www.w3.org/2001/XMLSchema#string"/>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:someValuesFrom>
          <owl:Class rdf:about="#Database"/>
        </owl:someValuesFrom>
        <owl:onProperty rdf:resource="#has_database"/>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:someValuesFrom rdf:resource="http://www.w3.org/2002/07/owl#Thing"/>
        <owl:onProperty>
          <owl:ObjectProperty rdf:about="#has_accession"/>
        </owl:onProperty>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:subClassOf>
      <owl:Class rdf:about="#DescriptionPackage"/>
    </rdfs:subClassOf>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:onProperty>
          <owl:ObjectProperty rdf:about="#has_value"/>
        </owl:onProperty>
        <owl:someValuesFrom rdf:resource="http://www.w3.org/2002/07/owl#Thing"/>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:label>OntologyEntry</rdfs:label>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:onProperty>
          <owl:ObjectProperty rdf:ID="has_database_entry_type"/>
        </owl:onProperty>
        <owl:someValuesFrom>
          <owl:Class rdf:about="#DatabaseEntryType"/>
        </owl:someValuesFrom>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:someValuesFrom rdf:resource="http://www.w3.org/2002/07/owl#Thing"/>
        <owl:onProperty>
          <owl:FunctionalProperty rdf:about="#has_accession_version"/>
        </owl:onProperty>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:comment>External (to the MGED ontology) controlled vocabulary or ontology that can be referred such as ICD-9 or Gene Ontology.</rdfs:comment>
  </owl:Class>
  <owl:Class rdf:ID="QualityControlDescription">
    <rdfs:subClassOf rdf:resource="#ExperimentPackage"/>
    <rdfs:comment>QualityControlDescription provides details of the quality control aspects of the experiment.</rdfs:comment>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:someValuesFrom>
          <owl:Class rdf:about="#QualityControlDescriptionType"/>
        </owl:someValuesFrom>
        <owl:onProperty rdf:resource="#has_type"/>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:label>QualityControlDescription</rdfs:label>
  </owl:Class>
  <owl:Class rdf:ID="MeasurementPackage">
    <rdfs:subClassOf rdf:resource="#MGEDCoreOntology"/>
    <rdfs:comment>MAGE package for measurement. </rdfs:comment>
    <rdfs:label>MeasurementPackage</rdfs:label>
  </owl:Class>
  <owl:Class rdf:ID="ComplexAction">
    <rdfs:comment>Complex actions are composed of multiple steps (as opposed to AtomicAction) e.g. mRNA labeling, protein purification.</rdfs:comment>
    <rdfs:label>ComplexAction</rdfs:label>
    <rdfs:subClassOf>
      <owl:Class rdf:about="#Action"/>
    </rdfs:subClassOf>
  </owl:Class>
  <owl:Class rdf:ID="PhysicalBioSequenceType">
    <rdfs:label>PhysicalBioSequenceType</rdfs:label>
    <rdfs:subClassOf>
      <owl:Class rdf:about="#BioSequenceType"/>
    </rdfs:subClassOf>
    <rdfs:comment>A physical biosequence type represents biological sequence that can be physically placed (spotted or synthesized) on an array e.g BAC, PAC.</rdfs:comment>
  </owl:Class>
  <owl:Class rdf:ID="BioSample">
    <rdfs:subClassOf>
      <owl:Class rdf:about="#BioMaterial"/>
    </rdfs:subClassOf>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:onProperty rdf:resource="#has_type"/>
        <owl:someValuesFrom>
          <owl:Class rdf:about="#BioSampleType"/>
        </owl:someValuesFrom>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:comment>The BioSource after any treatment.</rdfs:comment>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:someValuesFrom rdf:resource="#Treatment"/>
        <owl:onProperty>
          <owl:FunctionalProperty rdf:about="#has_been_treated"/>
        </owl:onProperty>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:label>BioSample</rdfs:label>
  </owl:Class>
  <owl:Class rdf:ID="BioSourceType">
    <rdfs:label>BioSourceType</rdfs:label>
    <rdfs:subClassOf rdf:resource="#BioMaterialCharacteristics"/>
    <rdfs:comment>The form in which the Biosource is provided, may also be used to describe biosamples e.g. agar stab.</rdfs:comment>
  </owl:Class>
  <owl:Class rdf:ID="BarrierFacility">
    <rdfs:comment>Rating of containment system for the protection of organisms from infectious agents.</rdfs:comment>
    <rdfs:subClassOf>
      <owl:Class rdf:about="#GrowthCondition"/>
    </rdfs:subClassOf>
    <rdfs:label>BarrierFacility</rdfs:label>
  </owl:Class>
  <owl:Class rdf:ID="PhysicalBioAssay">
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:someValuesFrom>
          <owl:Class rdf:about="#ImageFormat"/>
        </owl:someValuesFrom>
        <owl:onProperty>
          <owl:ObjectProperty rdf:about="#has_image_format"/>
        </owl:onProperty>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:subClassOf rdf:resource="#BioAssay"/>
    <rdfs:comment>A physical bioassay is the combination of arrays and biomaterials as in a hybridization.</rdfs:comment>
    <rdfs:label>PhysicalBioAssay</rdfs:label>
  </owl:Class>
  <owl:Class rdf:ID="FailType">
    <rdfs:subClassOf rdf:resource="#DesignElementPackage"/>
    <rdfs:comment>Controlled terms for descriptors of failures (as in PCR) associated with reporters.</rdfs:comment>
    <rdfs:label>FailType</rdfs:label>
  </owl:Class>
  <owl:Class rdf:ID="BioMaterialCharacteristicCategory">
    <rdfs:subClassOf>
      <owl:Class rdf:about="#BiologicalFactorCategory"/>
    </rdfs:subClassOf>
    <rdfs:label>BioMaterialCharacteristicCategory</rdfs:label>
    <rdfs:comment>General descriptor of a BioMaterialCharacteristic category.  Such as strain or line where the name of the strain or line is encoded in the FactorValue.  </rdfs:comment>
  </owl:Class>
  <owl:Class rdf:ID="Host">
    <rdfs:subClassOf rdf:resource="#EnvironmentalHistory"/>
    <rdfs:label>Host</rdfs:label>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:someValuesFrom>
          <owl:Class rdf:about="#Organism"/>
        </owl:someValuesFrom>
        <owl:onProperty>
          <owl:ObjectProperty rdf:about="#has_host"/>
        </owl:onProperty>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:onProperty>
          <owl:ObjectProperty rdf:about="#has_host_part"/>
        </owl:onProperty>
        <owl:someValuesFrom rdf:resource="#OrganismPart"/>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:comment>Organisms or organism parts used as a designed part of the culture (e.g., red blood cells, stromal cells). </rdfs:comment>
  </owl:Class>
  <owl:Class rdf:ID="PolymerType">
    <rdfs:subClassOf>
      <owl:Class rdf:about="#BioSequencePackage"/>
    </rdfs:subClassOf>
    <rdfs:label>PolymerType</rdfs:label>
    <rdfs:comment>Controlled terms for descriptors of the type of polymer (RNA, DNA, protein) of the biosequence.</rdfs:comment>
  </owl:Class>
  <owl:Class rdf:ID="TimeUnitOther">
    <rdfs:subClassOf>
      <owl:Class rdf:about="#TimeUnit"/>
    </rdfs:subClassOf>
    <rdfs:comment>Time units not specified in MAGE.</rdfs:comment>
    <rdfs:label>TimeUnitOther</rdfs:label>
  </owl:Class>
  <owl:Class rdf:ID="NodeValue">
    <rdfs:subClassOf>
      <owl:Class rdf:about="#HigherLevelAnalysisPackage"/>
    </rdfs:subClassOf>
    <rdfs:label>NodeValue</rdfs:label>
    <rdfs:comment>Node values allow the organization of the nodes in relation to other nodes produced by mathematical functions such as a clustering algorithm.</rdfs:comment>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:onProperty>
          <owl:ObjectProperty rdf:ID="has_node_value_type"/>
        </owl:onProperty>
        <owl:someValuesFrom>
          <owl:Class rdf:about="#NodeValueType"/>
        </owl:someValuesFrom>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:onProperty rdf:resource="#has_scale"/>
        <owl:someValuesFrom>
          <owl:Class rdf:about="#Scale"/>
        </owl:someValuesFrom>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:onProperty rdf:resource="#has_type"/>
        <owl:someValuesFrom>
          <owl:Class rdf:about="#DataType"/>
        </owl:someValuesFrom>
      </owl:Restriction>
    </rdfs:subClassOf>
  </owl:Class>
  <owl:Class rdf:ID="ZoneDefect">
    <rdfs:label>ZoneDefect</rdfs:label>
    <rdfs:comment>A technical manufactured described defect for zones.</rdfs:comment>
    <rdfs:subClassOf>
      <owl:Class rdf:about="#ArrayPackage"/>
    </rdfs:subClassOf>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:onProperty rdf:resource="#has_type"/>
        <owl:someValuesFrom rdf:resource="#DefectType"/>
      </owl:Restriction>
    </rdfs:subClassOf>
  </owl:Class>
  <owl:Class rdf:ID="PerturbationalDesign">
    <rdfs:subClassOf>
      <owl:Class rdf:about="#ExperimentDesignType"/>
    </rdfs:subClassOf>
    <rdfs:label>PerturbationalDesign</rdfs:label>
    <rdfs:comment>A perturbational design type is where the organism(s) are treated or manipulated or modified, for example a genetic modification, somatic modification </rdfs:comment>
  </owl:Class>
  <owl:Class rdf:ID="ArrayPackage">
    <rdfs:comment>MAGE package for describing the process by which arrays were manufactured.</rdfs:comment>
    <rdfs:subClassOf rdf:resource="#MGEDCoreOntology"/>
    <rdfs:label>ArrayPackage</rdfs:label>
  </owl:Class>
  <owl:Class rdf:ID="Scale">
    <rdfs:subClassOf rdf:resource="#MGEDOntology"/>
    <rdfs:label>Scale</rdfs:label>
    <rdfs:comment>The scale (linear, log10, ln, etc) used to represent the value.</rdfs:comment>
  </owl:Class>
  <owl:Class rdf:ID="Software">
    <rdfs:subClassOf rdf:resource="#ProtocolPackage"/>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:someValuesFrom>
          <owl:Class rdf:about="#SoftwareType"/>
        </owl:someValuesFrom>
        <owl:onProperty rdf:resource="#has_type"/>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:label>Software</rdfs:label>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:someValuesFrom rdf:resource="#Software"/>
        <owl:onProperty>
          <owl:ObjectProperty rdf:ID="has_software"/>
        </owl:onProperty>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:comment>The software application used.</rdfs:comment>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:onProperty>
          <owl:ObjectProperty rdf:ID="has_manufacturer"/>
        </owl:onProperty>
        <owl:someValuesFrom>
          <owl:Class rdf:about="#Contact"/>
        </owl:someValuesFrom>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:onProperty>
          <owl:ObjectProperty rdf:ID="has_hardware"/>
        </owl:onProperty>
        <owl:someValuesFrom>
          <owl:Class rdf:about="#Hardware"/>
        </owl:someValuesFrom>
      </owl:Restriction>
    </rdfs:subClassOf>
  </owl:Class>
  <owl:Class rdf:ID="Parameter">
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:onProperty>
          <owl:ObjectProperty rdf:ID="has_units"/>
        </owl:onProperty>
        <owl:someValuesFrom rdf:resource="#Unit"/>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:onProperty rdf:resource="#has_type"/>
        <owl:someValuesFrom>
          <owl:Class rdf:about="#DataType"/>
        </owl:someValuesFrom>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:label>Parameter</rdfs:label>
    <rdfs:subClassOf rdf:resource="#ProtocolPackage"/>
    <rdfs:comment>A parameter is a variable within a protocol. </rdfs:comment>
  </owl:Class>
  <owl:Class rdf:ID="DerivedBioAssayType">
    <rdfs:comment>Controlled set of descriptors for the type of derivation of the BioAssay such as averaging features, taking ratios of signal QuantitationTypes, and normalizing BioAssay data. </rdfs:comment>
    <rdfs:subClassOf rdf:resource="#BioAssayPackage"/>
    <rdfs:label>DerivedBioAssayType</rdfs:label>
  </owl:Class>
  <owl:Class rdf:ID="Experiment">
    <rdfs:subClassOf rdf:resource="#ExperimentPackage"/>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:someValuesFrom>
          <owl:Class rdf:about="#Contact"/>
        </owl:someValuesFrom>
        <owl:onProperty>
          <owl:ObjectProperty rdf:ID="has_providers"/>
        </owl:onProperty>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:onProperty>
          <owl:ObjectProperty rdf:ID="has_bioassay_data"/>
        </owl:onProperty>
        <owl:someValuesFrom rdf:resource="#BioAssayData"/>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:label>Experiment</rdfs:label>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:someValuesFrom>
          <owl:Class rdf:about="#BibliographicReference"/>
        </owl:someValuesFrom>
        <owl:onProperty>
          <owl:ObjectProperty rdf:ID="has_citation"/>
        </owl:onProperty>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:comment>The complete set of bioassays (hybridizations) and their descriptions performed as an experiment for a common purpose. Here we take experiment to mean an observational or perturbing study. An experiment will be often equivalent to a publication.</rdfs:comment>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:onProperty>
          <owl:ObjectProperty rdf:ID="has_experiment_design"/>
        </owl:onProperty>
        <owl:someValuesFrom>
          <owl:Class rdf:about="#ExperimentDesign"/>
        </owl:someValuesFrom>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:someValuesFrom rdf:resource="#BioAssay"/>
        <owl:onProperty>
          <owl:ObjectProperty rdf:ID="has_bioassays"/>
        </owl:onProperty>
      </owl:Restriction>
    </rdfs:subClassOf>
  </owl:Class>
  <owl:Class rdf:ID="HardwareType">
    <rdfs:comment>Controlled terms for descriptors of types of hardware.</rdfs:comment>
    <rdfs:label>HardwareType</rdfs:label>
    <rdfs:subClassOf rdf:resource="#ProtocolPackage"/>
  </owl:Class>
  <owl:Class rdf:ID="BioAssayDataCluster">
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:someValuesFrom rdf:resource="#Node"/>
        <owl:onProperty>
          <owl:ObjectProperty rdf:ID="has_nodes"/>
        </owl:onProperty>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:subClassOf>
      <owl:Class rdf:about="#HigherLevelAnalysisPackage"/>
    </rdfs:subClassOf>
    <rdfs:comment>A grouping of bioassay data that has been organized by one or more mathematical functions into nodes.</rdfs:comment>
    <rdfs:label>BioAssayDataCluster</rdfs:label>
  </owl:Class>
  <owl:Class rdf:ID="EnvironmentalFactorCategory">
    <rdfs:subClassOf>
      <owl:Class rdf:about="#ExperimentalFactorCategory"/>
    </rdfs:subClassOf>
    <rdfs:label>EnvironmentalFactorCategory</rdfs:label>
    <rdfs:comment>Factors that relate to properties of the environmental history of the biomaterial, its treatment, or its growth.</rdfs:comment>
  </owl:Class>
  <owl:Class rdf:ID="ChromosomalAberrationDatabase">
    <rdfs:subClassOf>
      <owl:Class rdf:about="#Database"/>
    </rdfs:subClassOf>
    <rdfs:label>ChromosomalAberrationDatabase</rdfs:label>
    <rdfs:comment>Database of chromosomal aberrations.</rdfs:comment>
  </owl:Class>
  <owl:Class rdf:ID="Database">
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:someValuesFrom rdf:resource="#URI"/>
        <owl:onProperty>
          <owl:FunctionalProperty rdf:about="#has_URI"/>
        </owl:onProperty>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:onProperty>
          <owl:ObjectProperty rdf:ID="has_version"/>
        </owl:onProperty>
        <owl:someValuesFrom rdf:resource="http://www.w3.org/2002/07/owl#Thing"/>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:comment>Identifiable resource containing data or external ontologies or controlled vocabularies which has uniquely identifiable records.</rdfs:comment>
    <rdfs:label>Database</rdfs:label>
    <rdfs:subClassOf>
      <owl:Class rdf:about="#DescriptionPackage"/>
    </rdfs:subClassOf>
  </owl:Class>
  <owl:Class rdf:ID="LightUnit">
    <rdfs:subClassOf>
      <owl:Class rdf:about="#OtherUnit"/>
    </rdfs:subClassOf>
    <rdfs:label>LightUnit</rdfs:label>
    <rdfs:comment>Units for measuring the intensity of light.</rdfs:comment>
  </owl:Class>
  <owl:Class rdf:ID="DevelopmentalStage">
    <rdfs:subClassOf rdf:resource="#BioMaterialCharacteristics"/>
    <rdfs:label>DevelopmentalStage</rdfs:label>
    <rdfs:comment>The developmental stage of the organism's life cycle during which the biomaterial was extracted. </rdfs:comment>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:onProperty rdf:resource="#has_database"/>
        <owl:someValuesFrom rdf:resource="#DevelopmentalStage"/>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:subClassOf rdf:resource="#OntologyEntry"/>
  </owl:Class>
  <owl:Class rdf:ID="QualityControlDescriptionType">
    <rdfs:comment>Controlled descriptors for the quality control strategy for an experiment. </rdfs:comment>
    <rdfs:label>QualityControlDescriptionType</rdfs:label>
    <rdfs:subClassOf rdf:resource="#ExperimentPackage"/>
  </owl:Class>
  <owl:Class rdf:ID="GeneticModification">
    <rdfs:comment>The genetic modification introduced into the organism from which the biomaterial was derived. Examples of genetic variation include specification of a transgene or the gene knocked-out. </rdfs:comment>
    <rdfs:subClassOf rdf:resource="#BioMaterialCharacteristics"/>
    <rdfs:label>GeneticModification</rdfs:label>
  </owl:Class>
  <owl:Class rdf:ID="TargetedCellType">
    <rdfs:comment>The target cell type is the cell of primary interest. The biomaterial may be derived from a mixed population of cells although only one cell type is of interest. </rdfs:comment>
    <rdfs:label>TargetedCellType</rdfs:label>
    <rdfs:subClassOf rdf:resource="#BioMaterialCharacteristics"/>
    <rdfs:subClassOf rdf:resource="#OntologyEntry"/>
  </owl:Class>
  <owl:Class rdf:ID="Cultivar">
    <rdfs:label>Cultivar</rdfs:label>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:onProperty rdf:resource="#has_database"/>
        <owl:someValuesFrom rdf:resource="#StrainOrLineDatabase"/>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:subClassOf rdf:resource="#StrainOrLine"/>
    <rdfs:comment> a plant variety obtained in in agriculture in horticulture</rdfs:comment>
  </owl:Class>
  <owl:Class rdf:ID="DataType">
    <rdfs:label>DataType</rdfs:label>
    <rdfs:comment>Primitive data types found in computing languages such as float, boolean, etc. </rdfs:comment>
    <rdfs:subClassOf rdf:resource="#MGEDOntology"/>
  </owl:Class>
  <owl:Class rdf:ID="DiseaseState">
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:someValuesFrom>
          <owl:Class rdf:about="#DiseaseStateDatabase"/>
        </owl:someValuesFrom>
        <owl:onProperty rdf:resource="#has_database"/>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:comment>The name of the pathology diagnosed in the organism from which the biomaterial was derived. The disease state is normal if no disease has been diagnosed. </rdfs:comment>
    <rdfs:subClassOf rdf:resource="#BioMaterialCharacteristics"/>
    <rdfs:subClassOf rdf:resource="#OntologyEntry"/>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:someValuesFrom>
          <owl:Class rdf:about="#DiseaseStaging"/>
        </owl:someValuesFrom>
        <owl:onProperty>
          <owl:ObjectProperty rdf:ID="has_disease_staging"/>
        </owl:onProperty>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:label>DiseaseState</rdfs:label>
  </owl:Class>
  <owl:Class rdf:ID="DesignElementGroup">
    <rdfs:comment>A DesignElementGroup holds information on Features, Reporters, or CompositeSequences.</rdfs:comment>
    <rdfs:subClassOf rdf:resource="#ArrayDesignPackage"/>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:onProperty>
          <owl:ObjectProperty rdf:ID="has_species"/>
        </owl:onProperty>
        <owl:someValuesFrom>
          <owl:Class rdf:about="#Organism"/>
        </owl:someValuesFrom>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:label>DesignElementGroup</rdfs:label>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:onProperty rdf:resource="#has_type"/>
        <owl:someValuesFrom rdf:resource="#DesignElementGroupType"/>
      </owl:Restriction>
    </rdfs:subClassOf>
  </owl:Class>
  <owl:Class rdf:ID="Biometrics">
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:onProperty>
          <owl:ObjectProperty rdf:ID="has_mass"/>
        </owl:onProperty>
        <owl:someValuesFrom>
          <owl:Class rdf:about="#Measurement"/>
        </owl:someValuesFrom>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:someValuesFrom>
          <owl:Class rdf:about="#Individual"/>
        </owl:someValuesFrom>
        <owl:onProperty>
          <owl:ObjectProperty rdf:ID="has_individual"/>
        </owl:onProperty>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:onProperty>
          <owl:ObjectProperty rdf:ID="has_organism_part"/>
        </owl:onProperty>
        <owl:someValuesFrom rdf:resource="#OrganismPart"/>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:onProperty>
          <owl:ObjectProperty rdf:ID="has_height"/>
        </owl:onProperty>
        <owl:someValuesFrom>
          <owl:Class rdf:about="#Measurement"/>
        </owl:someValuesFrom>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:label>Biometrics</rdfs:label>
    <rdfs:subClassOf rdf:resource="#BioMaterialCharacteristics"/>
    <rdfs:comment>Physical properties of the BioMaterial e. g. mass or height</rdfs:comment>
  </owl:Class>
  <owl:Class rdf:ID="Nutrients">
    <rdfs:comment>The food provided to the organism (e.g., chow, fertilizer, DEMM 10%FBS, etc.).</rdfs:comment>
    <rdfs:subClassOf>
      <owl:Class rdf:about="#GrowthCondition"/>
    </rdfs:subClassOf>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:someValuesFrom rdf:resource="#Compound"/>
        <owl:onProperty>
          <owl:ObjectProperty rdf:ID="has_nutrient_component"/>
        </owl:onProperty>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:label>Nutrients</rdfs:label>
  </owl:Class>
  <owl:Class rdf:ID="QuantitationTypePackage">
    <rdfs:comment>The MAGE package for defining classes for quantitation.</rdfs:comment>
    <rdfs:label>QuantitationTypePackage</rdfs:label>
    <rdfs:subClassOf rdf:resource="#MGEDCoreOntology"/>
  </owl:Class>
  <owl:Class rdf:ID="NormalizationDescription">
    <rdfs:subClassOf rdf:resource="#ExperimentPackage"/>
    <rdfs:comment>NormalizationDescription provides details of the normalization strategy for the experiment.</rdfs:comment>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:onProperty rdf:resource="#has_type"/>
        <owl:someValuesFrom rdf:resource="#NormalizationDescriptionType"/>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:label>NormalizationDescription</rdfs:label>
  </owl:Class>
  <owl:Class rdf:ID="GeographicLocation">
    <rdfs:label>GeographicLocation</rdfs:label>
    <rdfs:comment>A descriptor of the location from which a BioMaterial was obtained, e.g. country, region, grid reference.</rdfs:comment>
    <rdfs:subClassOf rdf:resource="#EnvironmentalHistory"/>
    <rdfs:subClassOf rdf:resource="#OntologyEntry"/>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:onProperty rdf:resource="#has_database"/>
        <owl:someValuesFrom rdf:resource="#GeographicLocationDatabase"/>
      </owl:Restriction>
    </rdfs:subClassOf>
  </owl:Class>
  <owl:Class rdf:ID="DiseaseStaging">
    <rdfs:subClassOf rdf:resource="#OntologyEntry"/>
    <rdfs:comment>The stage or progression of a disease in an organism. Includes pathological staging of cancers and other disease progression. </rdfs:comment>
    <rdfs:label>DiseaseStaging</rdfs:label>
    <rdfs:subClassOf rdf:resource="#BioMaterialCharacteristics"/>
  </owl:Class>
  <owl:Class rdf:ID="Hardware">
    <rdfs:subClassOf rdf:resource="#ProtocolPackage"/>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:onProperty rdf:resource="#has_manufacturer"/>
        <owl:someValuesFrom>
          <owl:Class rdf:about="#Contact"/>
        </owl:someValuesFrom>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:label>Hardware</rdfs:label>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:onProperty>
          <owl:ObjectProperty rdf:about="#has_make"/>
        </owl:onProperty>
        <owl:someValuesFrom rdf:resource="http://www.w3.org/2002/07/owl#Thing"/>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:onProperty rdf:resource="#has_type"/>
        <owl:someValuesFrom rdf:resource="#HardwareType"/>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:comment>The machine or instrument used.</rdfs:comment>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:onProperty rdf:resource="#has_software"/>
        <owl:someValuesFrom rdf:resource="#Software"/>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:onProperty>
          <owl:ObjectProperty rdf:about="#has_model"/>
        </owl:onProperty>
        <owl:someValuesFrom rdf:resource="http://www.w3.org/2002/07/owl#Thing"/>
      </owl:Restriction>
    </rdfs:subClassOf>
  </owl:Class>
  <owl:Class rdf:ID="CellType">
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:someValuesFrom>
          <owl:Class rdf:about="#CellTypeDatabase"/>
        </owl:someValuesFrom>
        <owl:onProperty rdf:resource="#has_database"/>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:subClassOf rdf:resource="#OntologyEntry"/>
    <rdfs:subClassOf rdf:resource="#BioMaterialCharacteristics"/>
    <rdfs:label>CellType</rdfs:label>
    <rdfs:comment>CellType, the type of cell used in the experiment if non mixed, if mixed the TargetedCellType should be used, example of instances, epithelial, glial etc.</rdfs:comment>
  </owl:Class>
  <owl:Class rdf:ID="GeneticMaterial">
    <rdfs:subClassOf>
      <owl:Class rdf:about="#MGEDExtendedOntology"/>
    </rdfs:subClassOf>
    <rdfs:comment>Genetic material may be DNA or RNA and identifiable as an entry in a public external database such as EMBL/DDBJ/GenBank or one of the model organism databases.</rdfs:comment>
    <rdfs:label>GeneticMaterial</rdfs:label>
  </owl:Class>
  <owl:Class rdf:ID="Fiducial">
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:someValuesFrom rdf:resource="#FiducialType"/>
        <owl:onProperty rdf:resource="#has_type"/>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:label>Fiducial</rdfs:label>
    <rdfs:subClassOf rdf:resource="#ArrayPackage"/>
    <rdfs:comment>A marking on the surface of the array that can be used to identify the origin of the array.</rdfs:comment>
  </owl:Class>
  <owl:Class rdf:ID="Generations">
    <rdfs:comment>The number of cell passages if the organism or organism part that is cultured is unicellular or a cell culture otherwise the number of generations.</rdfs:comment>
    <rdfs:subClassOf rdf:resource="#EnvironmentalHistory"/>
    <rdfs:label>Generations</rdfs:label>
  </owl:Class>
  <owl:Class rdf:ID="FeatureDefect">
    <rdfs:label>FeatureDefect</rdfs:label>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:onProperty rdf:resource="#has_type"/>
        <owl:someValuesFrom rdf:resource="#DefectType"/>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:comment>A technical manufacturer described defect for features.</rdfs:comment>
    <rdfs:subClassOf rdf:resource="#ArrayPackage"/>
  </owl:Class>
  <owl:Class rdf:ID="ProtocolVariation">
    <rdfs:label>ProtocolVariation</rdfs:label>
    <rdfs:comment>The effects of different protocols or changes in protocols on experimental results are studied.</rdfs:comment>
    <rdfs:subClassOf>
      <owl:Class rdf:about="#MGEDExtendedOntology"/>
    </rdfs:subClassOf>
  </owl:Class>
  <owl:Class rdf:ID="CellTypeDatabase">
    <rdfs:label>CellTypeDatabase</rdfs:label>
    <rdfs:subClassOf rdf:resource="#Database"/>
    <rdfs:comment>Database of cell type information.</rdfs:comment>
  </owl:Class>
  <owl:Class rdf:ID="EpidemiologicalDesign">
    <rdfs:label>EpidemiologicalDesign</rdfs:label>
    <rdfs:subClassOf>
      <owl:Class rdf:about="#ExperimentDesignType"/>
    </rdfs:subClassOf>
    <rdfs:comment>An epidemiological experiment design type is where the biosource history is studied e.g. environmental, clinical and family history.</rdfs:comment>
  </owl:Class>
  <owl:Class rdf:ID="Measurement">
    <rdfs:comment>Measured values and units.</rdfs:comment>
    <rdfs:subClassOf rdf:resource="#MeasurementPackage"/>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:onProperty>
          <owl:ObjectProperty rdf:about="#has_value"/>
        </owl:onProperty>
        <owl:someValuesFrom rdf:resource="http://www.w3.org/2002/07/owl#Thing"/>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:onProperty>
          <owl:ObjectProperty rdf:about="#has_measurement_type"/>
        </owl:onProperty>
        <owl:someValuesFrom>
          <owl:Class>
            <owl:oneOf rdf:parseType="Collection">
              <owl:Thing rdf:ID="absolute"/>
              <ProtocolType rdf:ID="change_biomaterial_characteristics">
                <rdf:type rdf:resource="#ComplexAction"/>
                <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#Thing"/>
              </ProtocolType>
              <owl:Thing rdf:ID="relative"/>
            </owl:oneOf>
          </owl:Class>
        </owl:someValuesFrom>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:someValuesFrom rdf:resource="#Unit"/>
        <owl:onProperty rdf:resource="#has_units"/>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:label>Measurement</rdfs:label>
  </owl:Class>
  <owl:Class rdf:ID="DistanceUnitOther">
    <rdfs:subClassOf rdf:resource="#DistanceUnit"/>
    <rdfs:comment>Distance units not specified in MAGE.</rdfs:comment>
    <rdfs:label>DistanceUnitOther</rdfs:label>
  </owl:Class>
  <owl:Class rdf:ID="CellLineDatabase">
    <rdfs:subClassOf rdf:resource="#Database"/>
    <rdfs:label>CellLineDatabase</rdfs:label>
    <rdfs:comment>Database of cell line information.</rdfs:comment>
  </owl:Class>
  <owl:Class rdf:ID="Haplotype">
    <rdfs:label>Haplotype</rdfs:label>
    <rdfs:subClassOf rdf:resource="#IndividualGeneticCharacteristics"/>
    <rdfs:comment>The genotype of a single chromosome (i.e., the haploid genotype) that is known and relevant to the experiment being performed. </rdfs:comment>
  </owl:Class>
  <owl:Class rdf:ID="Contact">
    <rdfs:subClassOf>
      <owl:Class rdf:about="#AuditAndSecurityPackage"/>
    </rdfs:subClassOf>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:someValuesFrom rdf:resource="http://www.w3.org/2002/07/owl#Thing"/>
        <owl:onProperty>
          <owl:ObjectProperty rdf:ID="has_phone"/>
        </owl:onProperty>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:onProperty>
          <owl:FunctionalProperty rdf:about="#has_URI"/>
        </owl:onProperty>
        <owl:someValuesFrom rdf:resource="#URI"/>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:onProperty>
          <owl:ObjectProperty rdf:ID="has_email"/>
        </owl:onProperty>
        <owl:someValuesFrom rdf:resource="http://www.w3.org/2002/07/owl#Thing"/>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:someValuesFrom rdf:resource="http://www.w3.org/2002/07/owl#Thing"/>
        <owl:onProperty>
          <owl:ObjectProperty rdf:ID="has_toll_free_phone"/>
        </owl:onProperty>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:label>Contact</rdfs:label>
    <rdfs:comment>Organizations or individuals that may be contacted.</rdfs:comment>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:someValuesFrom rdf:resource="http://www.w3.org/2002/07/owl#Thing"/>
        <owl:onProperty>
          <owl:ObjectProperty rdf:ID="has_address"/>
        </owl:onProperty>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:onProperty rdf:resource="#has_type"/>
        <owl:someValuesFrom>
          <owl:Class rdf:about="#Roles"/>
        </owl:someValuesFrom>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:someValuesFrom rdf:resource="http://www.w3.org/2002/07/owl#Thing"/>
        <owl:onProperty>
          <owl:ObjectProperty rdf:ID="has_fax"/>
        </owl:onProperty>
      </owl:Restriction>
    </rdfs:subClassOf>
  </owl:Class>
  <owl:Class rdf:ID="FactorValueDependency">
    <rdfs:subClassOf rdf:resource="#ExperimentPackage"/>
    <rdfs:comment>A group of FactorValues which refer to the same condition used to treat or describe a BioMaterial, e.g. 10% glucose, 1 hour OR larval stage, age 24 hours. </rdfs:comment>
    <rdfs:label>FactorValueDependency</rdfs:label>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:someValuesFrom rdf:resource="http://www.w3.org/2002/07/owl#Thing"/>
        <owl:onProperty>
          <owl:ObjectProperty rdf:about="#has_value"/>
        </owl:onProperty>
      </owl:Restriction>
    </rdfs:subClassOf>
  </owl:Class>
  <owl:Class rdf:ID="ProtocolType">
    <rdfs:comment>A controlled set of terms to provide a descriptor for the type of protocol.</rdfs:comment>
    <rdfs:subClassOf rdf:resource="#MethodologicalFactorCategory"/>
    <rdfs:label>ProtocolType</rdfs:label>
    <rdfs:subClassOf rdf:resource="#ProtocolPackage"/>
  </owl:Class>
  <owl:Class rdf:ID="MassUnit">
    <rdfs:label>MassUnit</rdfs:label>
    <rdfs:subClassOf rdf:resource="#Unit"/>
    <rdfs:comment>Units used for mass measurements.</rdfs:comment>
  </owl:Class>
  <owl:Class rdf:ID="BioSequenceType">
    <rdfs:label>BioSequenceType</rdfs:label>
    <rdfs:comment>Controlled terms for descriptors indicating the type of biosequence. Types may be physical (e.g BAC, cDNA clone), or  computational (e.g unigene cluster, consensus)</rdfs:comment>
    <rdfs:subClassOf>
      <owl:Class rdf:about="#BioSequencePackage"/>
    </rdfs:subClassOf>
  </owl:Class>
  <owl:Class rdf:ID="CompoundDatabase">
    <rdfs:label>CompoundDatabase</rdfs:label>
    <rdfs:subClassOf rdf:resource="#Database"/>
    <rdfs:comment>Database of compound information.</rdfs:comment>
  </owl:Class>
  <owl:Class rdf:ID="Bedding">
    <rdfs:comment>Refers to the bedding material present in an animals housing.</rdfs:comment>
    <rdfs:label>Bedding</rdfs:label>
    <rdfs:subClassOf rdf:resource="#EnvironmentalHistory"/>
  </owl:Class>
  <owl:Class rdf:ID="Water">
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:onProperty>
          <owl:ObjectProperty rdf:ID="has_additive"/>
        </owl:onProperty>
        <owl:someValuesFrom rdf:resource="#Compound"/>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:comment>Water consumed by or enveloping the organism that the biosource is derived from. </rdfs:comment>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:onProperty>
          <owl:ObjectProperty rdf:ID="has_treatment"/>
        </owl:onProperty>
        <owl:someValuesFrom>
          <owl:Class rdf:about="#Protocol"/>
        </owl:someValuesFrom>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:subClassOf>
      <owl:Class rdf:about="#GrowthCondition"/>
    </rdfs:subClassOf>
    <rdfs:label>Water</rdfs:label>
  </owl:Class>
  <owl:Class rdf:ID="VolumeUnitOther">
    <rdfs:comment>Volume units not specified in MAGE.</rdfs:comment>
    <rdfs:subClassOf>
      <owl:Class rdf:about="#VolumeUnit"/>
    </rdfs:subClassOf>
    <rdfs:label>VolumeUnitOther</rdfs:label>
  </owl:Class>
  <owl:Class rdf:ID="QuantityUnitOther">
    <rdfs:subClassOf>
      <owl:Class rdf:about="#QuantityUnit"/>
    </rdfs:subClassOf>
    <rdfs:label>QuantityUnitOther</rdfs:label>
    <rdfs:comment>Quantity units not specified in MAGE.</rdfs:comment>
  </owl:Class>
  <owl:Class rdf:ID="ExperimentDesignType">
    <rdfs:label>ExperimentDesignType</rdfs:label>
    <rdfs:comment>The ExperimentDesignType is the high level description for studies such as "time series", "dose response", etc.  </rdfs:comment>
    <rdfs:subClassOf rdf:resource="#ExperimentPackage"/>
  </owl:Class>
  <owl:Class rdf:ID="DatabaseEntryType">
    <rdfs:comment>Controlled set of descriptors for the type of database record such as a protein record (in SWISS-PROT) or a gene object (in SGD).</rdfs:comment>
    <rdfs:label>DatabaseEntryType</rdfs:label>
    <rdfs:subClassOf>
      <owl:Class rdf:about="#DescriptionPackage"/>
    </rdfs:subClassOf>
  </owl:Class>
  <owl:Class rdf:ID="NodeValueType">
    <rdfs:label>NodeValueType</rdfs:label>
    <rdfs:subClassOf>
      <owl:Class rdf:about="#HigherLevelAnalysisPackage"/>
    </rdfs:subClassOf>
    <rdfs:comment>Controlled set of terms for describing the type of values (e.g., Euclidean distance).</rdfs:comment>
  </owl:Class>
  <owl:Class rdf:ID="BioSampleType">
    <rdfs:label>BioSampleType</rdfs:label>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:onProperty>
          <owl:ObjectProperty rdf:ID="has_biosample_type"/>
        </owl:onProperty>
        <owl:someValuesFrom>
          <owl:Class>
            <owl:oneOf rdf:parseType="Collection">
              <owl:Thing rdf:ID="extract">
                <rdf:type rdf:resource="#BioSampleType"/>
                <rdfs:comment>The BioSample immediately before labeling.</rdfs:comment>
              </owl:Thing>
              <owl:Thing rdf:ID="not_extract">
                <rdf:type rdf:resource="#BioSampleType"/>
                <rdfs:comment>The BioSample at any stage other than immediately before labeling.</rdfs:comment>
              </owl:Thing>
            </owl:oneOf>
          </owl:Class>
        </owl:someValuesFrom>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:subClassOf>
      <owl:Class rdf:about="#BioMaterialPackage"/>
    </rdfs:subClassOf>
    <rdfs:comment>Used to tell when the BioSample is an extract or not.</rdfs:comment>
  </owl:Class>
  <owl:Class rdf:ID="ReplicateDescription">
    <rdfs:subClassOf rdf:resource="#ExperimentPackage"/>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:onProperty rdf:resource="#has_type"/>
        <owl:someValuesFrom rdf:resource="#ReplicateDescriptionType"/>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:label>ReplicateDescription</rdfs:label>
    <rdfs:comment>ReplicateDescription provides details about the type of replication used in the experiment.</rdfs:comment>
  </owl:Class>
  <owl:Class rdf:ID="ProtocolParameterType">
    <rdfs:subClassOf>
      <owl:Class rdf:about="#MGEDExtendedOntology"/>
    </rdfs:subClassOf>
    <rdfs:label>ProtocolParameterType</rdfs:label>
    <rdfs:comment>Descriptors for protocol parameter types, e.g. compound concentration, media type. </rdfs:comment>
  </owl:Class>
  <owl:Class rdf:ID="BioSequence">
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:someValuesFrom rdf:resource="#PolymerType"/>
        <owl:onProperty rdf:resource="#has_type"/>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:subClassOf>
      <owl:Class rdf:about="#BioSequencePackage"/>
    </rdfs:subClassOf>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:someValuesFrom>
          <owl:Class rdf:about="#Organism"/>
        </owl:someValuesFrom>
        <owl:onProperty rdf:resource="#has_species"/>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:someValuesFrom rdf:resource="#BioSequenceType"/>
        <owl:onProperty rdf:resource="#has_type"/>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:comment>A representation of a DNA, RNA, or protein sequence. </rdfs:comment>
    <rdfs:label>BioSequence</rdfs:label>
  </owl:Class>
  <owl:Class rdf:ID="TimeUnit">
    <rdfs:subClassOf rdf:resource="#Unit"/>
    <rdfs:label>TimeUnit</rdfs:label>
    <rdfs:comment>Units used for time measurements.</rdfs:comment>
  </owl:Class>
  <owl:Class rdf:ID="DescriptionPackage">
    <rdfs:label>DescriptionPackage</rdfs:label>
    <rdfs:comment>MAGE package for description of annotations and references to annotations.</rdfs:comment>
    <rdfs:subClassOf rdf:resource="#MGEDCoreOntology"/>
  </owl:Class>
  <owl:Class rdf:ID="Sex">
    <rdfs:comment>Term applied to any organism able to undergo sexual reproduction in order to differentiate the individuals or types involved. Sexual reproduction is defined as the ability to exchange genetic material with the potential of recombinant progeny.</rdfs:comment>
    <rdfs:subClassOf rdf:resource="#BioMaterialCharacteristics"/>
    <rdfs:label>Sex</rdfs:label>
  </owl:Class>
  <owl:Class rdf:ID="Individual">
    <rdfs:comment>Identifier or name of the individual organism from which the biomaterial was derived. </rdfs:comment>
    <rdfs:label>Individual</rdfs:label>
    <rdfs:subClassOf rdf:resource="#BioMaterialCharacteristics"/>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:someValuesFrom rdf:resource="http://www.w3.org/2002/07/owl#Thing"/>
        <owl:onProperty rdf:resource="#has_ID"/>
      </owl:Restriction>
    </rdfs:subClassOf>
  </owl:Class>
  <owl:Class rdf:ID="ExperimentDesign">
    <rdfs:comment>ExperimentDesign refers to both observational and experimental (perturbational) studies. The organizing principles of the study including the relationships between assays and the steps taken to interpret the data. </rdfs:comment>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:onProperty>
          <owl:ObjectProperty rdf:ID="has_MAGE_description"/>
        </owl:onProperty>
        <owl:someValuesFrom rdf:resource="#NormalizationDescription"/>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:someValuesFrom rdf:resource="#BioAssay"/>
        <owl:onProperty rdf:resource="#has_bioassays"/>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:someValuesFrom rdf:resource="#ReplicateDescription"/>
        <owl:onProperty rdf:resource="#has_MAGE_description"/>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:someValuesFrom rdf:resource="#ExperimentalFactor"/>
        <owl:onProperty>
          <owl:ObjectProperty rdf:ID="has_experiment_factors"/>
        </owl:onProperty>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:subClassOf rdf:resource="#ExperimentPackage"/>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:someValuesFrom rdf:resource="http://www.w3.org/2001/XMLSchema#string"/>
        <owl:onProperty rdf:resource="#has_description"/>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:someValuesFrom rdf:resource="#QualityControlDescription"/>
        <owl:onProperty rdf:resource="#has_MAGE_description"/>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:someValuesFrom rdf:resource="#ExperimentDesignType"/>
        <owl:onProperty>
          <owl:ObjectProperty rdf:ID="has_experiment_design_type"/>
        </owl:onProperty>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:label>ExperimentDesign</rdfs:label>
  </owl:Class>
  <owl:Class rdf:ID="Temperature">
    <rdfs:label>Temperature</rdfs:label>
    <rdfs:comment>The temperature that a biosource is exposed to.</rdfs:comment>
    <rdfs:subClassOf>
      <owl:Class rdf:about="#GrowthCondition"/>
    </rdfs:subClassOf>
  </owl:Class>
  <owl:Class rdf:ID="AuditAndSecurityPackage">
    <rdfs:label>AuditAndSecurityPackage</rdfs:label>
    <rdfs:comment>MAGE package for contacts including organizations and people.</rdfs:comment>
    <rdfs:subClassOf rdf:resource="#MGEDCoreOntology"/>
  </owl:Class>
  <owl:Class rdf:ID="DesignElement">
    <rdfs:subClassOf rdf:resource="#DesignElementPackage"/>
    <rdfs:comment>Design elements are reporters, features, and composite elements as defined by MAGE.</rdfs:comment>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:onProperty rdf:resource="#has_type"/>
        <owl:someValuesFrom rdf:resource="#ControlType"/>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:label>DesignElement</rdfs:label>
  </owl:Class>
  <owl:Class rdf:ID="HistologyDatabase">
    <rdfs:comment>Database of histology information.</rdfs:comment>
    <rdfs:label>HistologyDatabase</rdfs:label>
    <rdfs:subClassOf rdf:resource="#Database"/>
  </owl:Class>
  <owl:Class rdf:ID="Preservation">
    <rdfs:label>Preservation</rdfs:label>
    <rdfs:comment>Method and type of preserving the organism or biosource (i.e. keeping it in stasis).</rdfs:comment>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:someValuesFrom>
          <owl:Class rdf:about="#PreservationType"/>
        </owl:someValuesFrom>
        <owl:onProperty rdf:resource="#has_type"/>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:someValuesFrom>
          <owl:Class rdf:about="#Protocol"/>
        </owl:someValuesFrom>
        <owl:onProperty rdf:resource="#has_protocol"/>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:subClassOf>
      <owl:Class rdf:about="#MGEDExtendedOntology"/>
    </rdfs:subClassOf>
  </owl:Class>
  <owl:Class rdf:ID="Organization">
    <rdfs:comment>The organization (e.g, company, hospital) to contact to obtain or purchase something.</rdfs:comment>
    <rdfs:label>Organization</rdfs:label>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:onProperty>
          <owl:ObjectProperty rdf:ID="has_name"/>
        </owl:onProperty>
        <owl:someValuesFrom rdf:resource="http://www.w3.org/2002/07/owl#Thing"/>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:subClassOf rdf:resource="#Contact"/>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:someValuesFrom rdf:resource="#Organization"/>
        <owl:onProperty>
          <owl:ObjectProperty rdf:ID="has_parent_organization"/>
        </owl:onProperty>
      </owl:Restriction>
    </rdfs:subClassOf>
  </owl:Class>
  <owl:Class rdf:ID="Age">
    <rdfs:comment>The time period elapsed since an identifiable point in the life cycle of an organism. If a developmental stage is specified, the identifiable point would be the beginning of that stage. Otherwise the identifiable point must be specified such as planting.</rdfs:comment>
    <rdfs:label>Age</rdfs:label>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:someValuesFrom rdf:resource="#Measurement"/>
        <owl:onProperty rdf:resource="#has_measurement"/>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:someValuesFrom rdf:resource="#Measurement"/>
        <owl:onProperty>
          <owl:ObjectProperty rdf:about="#has_maximum_measurement"/>
        </owl:onProperty>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:onProperty>
          <owl:ObjectProperty rdf:about="#has_initial_time_point"/>
        </owl:onProperty>
        <owl:someValuesFrom rdf:resource="#InitialTimePoint"/>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:subClassOf rdf:resource="#BioMaterialCharacteristics"/>
  </owl:Class>
  <owl:Class rdf:ID="VolumeUnit">
    <rdfs:comment>Units used for volume measurements.</rdfs:comment>
    <rdfs:subClassOf rdf:resource="#Unit"/>
    <rdfs:label>VolumeUnit</rdfs:label>
  </owl:Class>
  <owl:Class rdf:ID="Roles">
    <rdfs:subClassOf rdf:resource="#AuditAndSecurityPackage"/>
    <rdfs:label>Roles</rdfs:label>
    <rdfs:comment>Controlled terms for descriptors of the role of contact, e.g. submitter, biosource_provider.</rdfs:comment>
  </owl:Class>
  <owl:Class rdf:ID="DiseaseStateDatabase">
    <rdfs:comment>Database of disease state information.</rdfs:comment>
    <rdfs:label>DiseaseStateDatabase</rdfs:label>
    <rdfs:subClassOf rdf:resource="#Database"/>
  </owl:Class>
  <owl:Class rdf:ID="BioMaterialPackage">
    <rdfs:subClassOf rdf:resource="#MGEDCoreOntology"/>
    <rdfs:comment>Description of the source of the nucleic acid used to generate labeled material for the microarray experiment. </rdfs:comment>
    <rdfs:label>BioMaterialPackage</rdfs:label>
  </owl:Class>
  <owl:Class rdf:ID="GrowthCondition">
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:someValuesFrom rdf:resource="#Measurement"/>
        <owl:onProperty rdf:resource="#has_measurement"/>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:someValuesFrom rdf:resource="#Measurement"/>
        <owl:onProperty>
          <owl:ObjectProperty rdf:about="#has_maximum_measurement"/>
        </owl:onProperty>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:someValuesFrom rdf:resource="http://www.w3.org/2002/07/owl#Thing"/>
        <owl:onProperty>
          <owl:ObjectProperty rdf:about="#has_value"/>
        </owl:onProperty>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:subClassOf rdf:resource="#EnvironmentalHistory"/>
    <rdfs:comment>A description of the conditions used to grow organisms or parts of the organism. This includes isolated environments such as cultures and open environments such as field studies.</rdfs:comment>
    <rdfs:label>GrowthCondition</rdfs:label>
  </owl:Class>
  <owl:Class rdf:ID="IndividualChromosomalAbnormality">
    <rdfs:label>IndividualChromosomalAbnormality</rdfs:label>
    <rdfs:comment>An abnormality in the number or structure of chromosomes in the biomaterial from an individual organism, detected by karyotyping or other methods. E.g., a B-cell lymphoma from a patient has an abnormal karyotype 48,XY,t(1;2)(p22;p11),+3,+12.</rdfs:comment>
    <rdfs:subClassOf rdf:resource="#IndividualGeneticCharacteristics"/>
  </owl:Class>
  <owl:Class rdf:ID="BioAssayDataPackage">
    <rdfs:comment>MAGE package for BioAssayData.</rdfs:comment>
    <rdfs:subClassOf>
      <owl:Class rdf:about="#MGEDExtendedOntology"/>
    </rdfs:subClassOf>
    <rdfs:label>BioAssayDataPackage</rdfs:label>
  </owl:Class>
  <owl:Class rdf:ID="FamilyMember">
    <rdfs:comment>Member of the biosource's family.</rdfs:comment>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:onProperty>
          <owl:ObjectProperty rdf:ID="has_family_relationship"/>
        </owl:onProperty>
        <owl:someValuesFrom rdf:resource="#FamilyRelationship"/>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:someValuesFrom rdf:resource="#IndividualGeneticCharacteristics"/>
        <owl:onProperty>
          <owl:ObjectProperty rdf:ID="has_individual_genetic_characteristics"/>
        </owl:onProperty>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:onProperty>
          <owl:ObjectProperty rdf:ID="has_clinical_record"/>
        </owl:onProperty>
        <owl:someValuesFrom rdf:resource="#OntologyEntry"/>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:subClassOf rdf:resource="#BioMaterialPackage"/>
    <rdfs:label>FamilyMember</rdfs:label>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:someValuesFrom rdf:resource="#DiseaseState"/>
        <owl:onProperty>
          <owl:ObjectProperty rdf:ID="has_disease_state"/>
        </owl:onProperty>
      </owl:Restriction>
    </rdfs:subClassOf>
  </owl:Class>
  <owl:Class rdf:ID="ClinicalFinding">
    <rdfs:comment>Clinical findings that are distinct from the disease state and can be referred to from an established controlled vocabulary or ontology. An example might be a test performed and/or finding.</rdfs:comment>
    <rdfs:label>ClinicalFinding</rdfs:label>
    <rdfs:subClassOf rdf:resource="#OntologyEntry"/>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:onProperty>
          <owl:ObjectProperty rdf:ID="has_clinical_finding"/>
        </owl:onProperty>
        <owl:someValuesFrom rdf:resource="#Measurement"/>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:someValuesFrom rdf:resource="#LaboratoryTestDatabase"/>
        <owl:onProperty rdf:resource="#has_database"/>
      </owl:Restriction>
    </rdfs:subClassOf>
  </owl:Class>
  <owl:Class rdf:ID="ClinicalHistory">
    <rdfs:label>ClinicalHistory</rdfs:label>
    <rdfs:subClassOf rdf:resource="#EnvironmentalHistory"/>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:onProperty>
          <owl:ObjectProperty rdf:ID="has_prior_disease_state"/>
        </owl:onProperty>
        <owl:someValuesFrom rdf:resource="#DiseaseState"/>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:someValuesFrom rdf:resource="#ClinicalTreatment"/>
        <owl:onProperty>
          <owl:ObjectProperty rdf:ID="has_clinical_treatment"/>
        </owl:onProperty>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:comment>The BioMaterial's (i.e., the patient's) medical record as background information relevant to the experiment.</rdfs:comment>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:someValuesFrom>
          <owl:Class rdf:about="#ClinicalTestType"/>
        </owl:someValuesFrom>
        <owl:onProperty rdf:resource="#has_clinical_test_type"/>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:onProperty rdf:resource="#has_clinical_record"/>
        <owl:someValuesFrom rdf:resource="#OntologyEntry"/>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:someValuesFrom rdf:resource="#ClinicalFinding"/>
        <owl:onProperty rdf:resource="#has_clinical_finding"/>
      </owl:Restriction>
    </rdfs:subClassOf>
  </owl:Class>
  <owl:Class rdf:ID="BiologicalFactorCategory">
    <rdfs:comment>Factors that relate to properties of the biomaterial, its treatment, or its growth.</rdfs:comment>
    <rdfs:label>BiologicalFactorCategory</rdfs:label>
    <rdfs:subClassOf>
      <owl:Class rdf:about="#ExperimentalFactorCategory"/>
    </rdfs:subClassOf>
  </owl:Class>
  <owl:Class rdf:ID="BioSequencePackage">
    <rdfs:subClassOf rdf:resource="#MGEDCoreOntology"/>
    <rdfs:label>BioSequencePackage</rdfs:label>
    <rdfs:comment>MAGE package for biological sequences (biosequence).</rdfs:comment>
  </owl:Class>
  <owl:Class rdf:ID="Phenotype">
    <rdfs:comment>The observable form taken by some character (or group of characters) in an individual or an organism, excluding pathology and diesease.  The detectable outward manifestations of a specific genotype.</rdfs:comment>
    <rdfs:label>Phenotype</rdfs:label>
    <rdfs:subClassOf rdf:resource="#BioMaterialCharacteristics"/>
    <rdfs:subClassOf rdf:resource="#OntologyEntry"/>
  </owl:Class>
  <owl:Class rdf:ID="Histology">
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:someValuesFrom rdf:resource="#OrganismPart"/>
        <owl:onProperty rdf:resource="#has_organism_part"/>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:label>Histology</rdfs:label>
    <rdfs:comment>Microscopic morphology of tissues.</rdfs:comment>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:onProperty rdf:resource="#has_database"/>
        <owl:someValuesFrom rdf:resource="#HistologyDatabase"/>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:subClassOf rdf:resource="#BioMaterialCharacteristics"/>
  </owl:Class>
  <owl:Class rdf:ID="Action">
    <rdfs:label>Action</rdfs:label>
    <rdfs:subClassOf rdf:resource="#BiologicalFactorCategory"/>
    <rdfs:comment>Procedures used during treatment.</rdfs:comment>
    <rdfs:subClassOf rdf:resource="#BioMaterialPackage"/>
  </owl:Class>
  <owl:Class rdf:ID="PreservationType">
    <rdfs:subClassOf>
      <owl:Class rdf:about="#MGEDExtendedOntology"/>
    </rdfs:subClassOf>
    <rdfs:comment>The type of method used to preserve (keep in stasis) the organism or biosource.  </rdfs:comment>
    <rdfs:label>PreservationType</rdfs:label>
  </owl:Class>
  <owl:Class rdf:ID="MGEDExtendedOntology">
    <rdfs:comment>Location for those classes that are not in the Core ontology as they do are not containable in MAGE. It is not yet structured to work with the Core ontology </rdfs:comment>
    <rdfs:subClassOf rdf:resource="#MGEDOntology"/>
    <rdfs:label>MGEDExtendedOntology</rdfs:label>
  </owl:Class>
  <owl:Class rdf:ID="SurfaceType">
    <rdfs:subClassOf rdf:resource="#ArrayDesignPackage"/>
    <rdfs:comment>Controlled terms for descriptors for coating of the substrate.</rdfs:comment>
    <rdfs:label>SurfaceType</rdfs:label>
  </owl:Class>
  <owl:Class rdf:ID="OtherUnit">
    <rdfs:subClassOf rdf:resource="#Unit"/>
    <rdfs:label>OtherUnit</rdfs:label>
    <rdfs:comment>Other units are those types not specified in MAGE such as lumens, radioactivity, etc.</rdfs:comment>
  </owl:Class>
  <owl:Class rdf:ID="OrganismPartDatabase">
    <rdfs:comment>Database of organism part information.</rdfs:comment>
    <rdfs:subClassOf rdf:resource="#Database"/>
    <rdfs:label>OrganismPartDatabase</rdfs:label>
  </owl:Class>
  <owl:Class rdf:ID="BibliographicReference">
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:someValuesFrom rdf:resource="http://www.w3.org/2002/07/owl#Thing"/>
        <owl:onProperty>
          <owl:ObjectProperty rdf:ID="has_year"/>
        </owl:onProperty>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:onProperty>
          <owl:ObjectProperty rdf:ID="has_authors"/>
        </owl:onProperty>
        <owl:someValuesFrom rdf:resource="http://www.w3.org/2002/07/owl#Thing"/>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:onProperty>
          <owl:ObjectProperty rdf:about="#has_issue"/>
        </owl:onProperty>
        <owl:someValuesFrom rdf:resource="http://www.w3.org/2002/07/owl#Thing"/>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:label>BibliographicReference</rdfs:label>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:someValuesFrom rdf:resource="http://www.w3.org/2002/07/owl#Thing"/>
        <owl:onProperty>
          <owl:ObjectProperty rdf:about="#has_volume"/>
        </owl:onProperty>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:someValuesFrom rdf:resource="http://www.w3.org/2002/07/owl#Thing"/>
        <owl:onProperty>
          <owl:ObjectProperty rdf:about="#has_pages"/>
        </owl:onProperty>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:subClassOf rdf:resource="#DescriptionPackage"/>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:onProperty>
          <owl:ObjectProperty rdf:ID="has_editor"/>
        </owl:onProperty>
        <owl:someValuesFrom rdf:resource="http://www.w3.org/2002/07/owl#Thing"/>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:someValuesFrom>
          <owl:Class rdf:about="#PublicationType"/>
        </owl:someValuesFrom>
        <owl:onProperty rdf:resource="#has_type"/>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:onProperty>
          <owl:ObjectProperty rdf:ID="has_publication"/>
        </owl:onProperty>
        <owl:someValuesFrom rdf:resource="http://www.w3.org/2002/07/owl#Thing"/>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:comment>A bibliographic reference is a published citation in a journal, book, other format e.g. web resource</rdfs:comment>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:onProperty>
          <owl:FunctionalProperty rdf:about="#has_URI"/>
        </owl:onProperty>
        <owl:someValuesFrom rdf:resource="#URI"/>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:someValuesFrom rdf:resource="http://www.w3.org/2001/XMLSchema#string"/>
        <owl:onProperty>
          <owl:DatatypeProperty rdf:ID="has_title"/>
        </owl:onProperty>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:onProperty>
          <owl:ObjectProperty rdf:ID="has_publisher"/>
        </owl:onProperty>
        <owl:someValuesFrom rdf:resource="http://www.w3.org/2002/07/owl#Thing"/>
      </owl:Restriction>
    </rdfs:subClassOf>
  </owl:Class>
  <owl:Class rdf:ID="SoftwareType">
    <rdfs:label>SoftwareType</rdfs:label>
    <rdfs:subClassOf rdf:resource="#ProtocolPackage"/>
    <rdfs:comment>Controlled terms that provide descriptors for the type of software.</rdfs:comment>
  </owl:Class>
  <owl:Class rdf:ID="FactorValue">
    <rdfs:comment>The value of an ExperimentFactor.</rdfs:comment>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:onProperty>
          <owl:ObjectProperty rdf:ID="has_property_set"/>
        </owl:onProperty>
        <owl:someValuesFrom rdf:resource="#FactorValueDependency"/>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:label>FactorValue</rdfs:label>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:someValuesFrom rdf:resource="#Measurement"/>
        <owl:onProperty rdf:resource="#has_measurement"/>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:onProperty rdf:resource="#has_property_set"/>
        <owl:someValuesFrom>
          <owl:Class rdf:about="#FactorValueSet"/>
        </owl:someValuesFrom>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:onProperty>
          <owl:ObjectProperty rdf:ID="has_factor_value_ontology_entry"/>
        </owl:onProperty>
        <owl:someValuesFrom>
          <owl:Class rdf:about="#ExperimentalFactorCategory"/>
        </owl:someValuesFrom>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:subClassOf rdf:resource="#ExperimentPackage"/>
  </owl:Class>
  <owl:Class rdf:ID="RadiationUnit">
    <rdfs:subClassOf rdf:resource="#OtherUnit"/>
    <rdfs:label>RadiationUnit</rdfs:label>
    <rdfs:comment>Units for measuring decay of a radioactive isotope over time.</rdfs:comment>
  </owl:Class>
  <owl:Class rdf:ID="ExperimentalFactorCategory">
    <rdfs:comment>A factor category describes factors which are under test in the experiment and allowable factor categories can be BioMaterialCharacteristics, Compound (names, concentrations) and Action etc. E.g. in an experiment where leukemia types are compared the factor categories are ALL  and AML. </rdfs:comment>
    <rdfs:subClassOf rdf:resource="#ExperimentPackage"/>
    <rdfs:label>ExperimentalFactorCategory</rdfs:label>
  </owl:Class>
  <owl:Class rdf:ID="DeprecatedTerms">
    <rdfs:comment>Class to hold deprecated instances and classes.</rdfs:comment>
    <rdfs:subClassOf rdf:resource="#MGEDOntology"/>
    <rdfs:label>DeprecatedTerms</rdfs:label>
  </owl:Class>
  <owl:Class rdf:ID="SeqFeatureBasis">
    <rdfs:label>SeqFeatureBasis</rdfs:label>
    <rdfs:subClassOf rdf:resource="#BioSequencePackage"/>
    <rdfs:comment>Controlled terms for how the sequence features were determined (e.g., experimental, computational, etc.)</rdfs:comment>
  </owl:Class>
  <owl:Class rdf:ID="ClinicalTestType">
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:onProperty rdf:resource="#has_database"/>
        <owl:someValuesFrom rdf:resource="#LaboratoryTestDatabase"/>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:comment></rdfs:comment>
    <rdfs:subClassOf rdf:resource="#BioMaterialCharacteristics"/>
    <rdfs:label>ClinicalTestType</rdfs:label>
  </owl:Class>
  <owl:Class rdf:ID="PublicationType">
    <rdfs:subClassOf rdf:resource="#DescriptionPackage"/>
    <rdfs:label>PublicationType</rdfs:label>
    <rdfs:comment>Controlled terms for descriptors of the type of publication such as those used by Medline (review, book, etc.).</rdfs:comment>
  </owl:Class>
  <owl:Class rdf:ID="DerivedBioAssay">
    <rdfs:label>DerivedBioAssay</rdfs:label>
    <rdfs:comment>A BioAssay that is created by the transformation of measured or derived BioAssays.</rdfs:comment>
    <rdfs:subClassOf rdf:resource="#BioAssay"/>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:onProperty rdf:resource="#has_type"/>
        <owl:someValuesFrom rdf:resource="#DerivedBioAssayType"/>
      </owl:Restriction>
    </rdfs:subClassOf>
  </owl:Class>
  <owl:Class rdf:ID="QuantityUnit">
    <rdfs:label>QuantityUnit</rdfs:label>
    <rdfs:subClassOf rdf:resource="#Unit"/>
    <rdfs:comment>Units used for quantity measurements.</rdfs:comment>
  </owl:Class>
  <owl:Class rdf:ID="ImageFormat">
    <rdfs:label>ImageFormat</rdfs:label>
    <rdfs:comment>Controlled terms for descriptors of the image file format (TIFF, JPEG, GIF, etc.)</rdfs:comment>
    <rdfs:subClassOf rdf:resource="#BioAssayPackage"/>
  </owl:Class>
  <owl:Class rdf:ID="PhysicalArrayDesign">
    <rdfs:subClassOf rdf:resource="#ArrayDesignPackage"/>
    <rdfs:comment>Descriptions pertaining to the array.</rdfs:comment>
    <rdfs:label>PhysicalArrayDesign</rdfs:label>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:onProperty rdf:resource="#has_type"/>
        <owl:someValuesFrom rdf:resource="#SurfaceType"/>
      </owl:Restriction>
    </rdfs:subClassOf>
  </owl:Class>
  <owl:Class rdf:ID="BioMolecularAnnotation">
    <rdfs:comment>BioMolecularAnnotation experiment design types are those which are designed to investigate functions, processes, locations and identity at the molecular level e.g. binding site identification, genotyping.</rdfs:comment>
    <rdfs:label>BioMolecularAnnotation</rdfs:label>
    <rdfs:subClassOf rdf:resource="#ExperimentDesignType"/>
  </owl:Class>
  <owl:Class rdf:ID="Protocol">
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:onProperty rdf:resource="#has_description"/>
        <owl:someValuesFrom rdf:resource="http://www.w3.org/2001/XMLSchema#string"/>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:onProperty>
          <owl:FunctionalProperty rdf:about="#has_URI"/>
        </owl:onProperty>
        <owl:someValuesFrom rdf:resource="#URI"/>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:someValuesFrom rdf:resource="http://www.w3.org/2001/XMLSchema#string"/>
        <owl:onProperty rdf:resource="#has_title"/>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:onProperty rdf:resource="#has_citation"/>
        <owl:someValuesFrom rdf:resource="#BibliographicReference"/>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:comment>Documentation of the set of steps taken in a procedure.</rdfs:comment>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:someValuesFrom rdf:resource="http://www.w3.org/2002/07/owl#Thing"/>
        <owl:onProperty>
          <owl:ObjectProperty rdf:ID="has_text"/>
        </owl:onProperty>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:someValuesFrom rdf:resource="#Hardware"/>
        <owl:onProperty rdf:resource="#has_hardware"/>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:subClassOf rdf:resource="#ProtocolPackage"/>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:someValuesFrom rdf:resource="#ProtocolType"/>
        <owl:onProperty rdf:resource="#has_type"/>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:label>Protocol</rdfs:label>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:someValuesFrom rdf:resource="#Software"/>
        <owl:onProperty rdf:resource="#has_software"/>
      </owl:Restriction>
    </rdfs:subClassOf>
  </owl:Class>
  <owl:Class rdf:ID="DevelopmentalStageDatabase">
    <rdfs:comment>Database of developmental stage information.</rdfs:comment>
    <rdfs:subClassOf rdf:resource="#Database"/>
    <rdfs:label>DevelopmentalStageDatabase</rdfs:label>
  </owl:Class>
  <owl:Class rdf:ID="Transformation">
    <rdfs:comment>The process by which BioAssays (data, elements, quantitation types) are averaged normalized, selected, filtered, or otherwise changed into a new set of BioAssay data.</rdfs:comment>
    <rdfs:subClassOf rdf:resource="#BioAssayDataPackage"/>
    <rdfs:label>Transformation</rdfs:label>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:someValuesFrom rdf:resource="#Protocol"/>
        <owl:onProperty rdf:resource="#has_protocol"/>
      </owl:Restriction>
    </rdfs:subClassOf>
  </owl:Class>
  <owl:Class rdf:ID="FactorValueSet">
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:someValuesFrom rdf:resource="http://www.w3.org/2002/07/owl#Thing"/>
        <owl:onProperty>
          <owl:ObjectProperty rdf:about="#has_value"/>
        </owl:onProperty>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:comment>A super grouping of FactorValueDependencies or FactorValues which describes combinations of conditions used to treat or describe a BioMaterial applied to a BioAssay, typically separating things on the basis of channels or the concepts of measured and reference samples e.g. 10% glucose, 1 hour AND 10mm NaCl, 2 hours in channel 1. </rdfs:comment>
    <rdfs:subClassOf rdf:resource="#ExperimentPackage"/>
    <rdfs:label>FactorValueSet</rdfs:label>
  </owl:Class>
  <owl:Class rdf:ID="Atmosphere">
    <rdfs:comment>The atmospheric conditions used to culture or grow an organism.</rdfs:comment>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:onProperty>
          <owl:ObjectProperty rdf:ID="has_atmospheric_component"/>
        </owl:onProperty>
        <owl:someValuesFrom rdf:resource="#Compound"/>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:subClassOf rdf:resource="#GrowthCondition"/>
    <rdfs:label>Atmosphere</rdfs:label>
  </owl:Class>
  <owl:Class rdf:ID="Ploidy">
    <rdfs:subClassOf rdf:resource="#IndividualGeneticCharacteristics"/>
    <rdfs:comment>The number of single sets of chromosomes in the cell or an organism e.g., haploid, diploid, triploid, etc.</rdfs:comment>
    <rdfs:label>Ploidy</rdfs:label>
  </owl:Class>
  <owl:Class rdf:ID="LabeledExtract">
    <rdfs:subClassOf>
      <owl:Class rdf:about="#BioMaterial"/>
    </rdfs:subClassOf>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:onProperty>
          <owl:ObjectProperty rdf:ID="has_compound"/>
        </owl:onProperty>
        <owl:someValuesFrom rdf:resource="#LabelCompound"/>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:label>LabeledExtract</rdfs:label>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:someValuesFrom rdf:resource="#Treatment"/>
        <owl:onProperty>
          <owl:FunctionalProperty rdf:about="#has_been_treated"/>
        </owl:onProperty>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:comment>The BioSample after labeling for detection of the nucleic acids. </rdfs:comment>
  </owl:Class>
  <owl:Class rdf:ID="DeliveryMethod">
    <rdfs:label>DeliveryMethod</rdfs:label>
    <rdfs:comment>Method used to deliver a compound for treatment.</rdfs:comment>
    <rdfs:subClassOf rdf:resource="#MGEDExtendedOntology"/>
  </owl:Class>
  <owl:Class rdf:ID="SoftwareVariation">
    <rdfs:label>SoftwareVariation</rdfs:label>
    <rdfs:subClassOf rdf:resource="#MethodologicalFactorCategory"/>
    <rdfs:comment>The effects of different software, software packages, or software versions on experimental results are studied.</rdfs:comment>
  </owl:Class>
  <owl:Class rdf:ID="BiologicalProperty">
    <rdfs:label>BiologicalProperty</rdfs:label>
    <rdfs:comment>A biological property experiment design type is where an intrinsic characteristic of an organism(s) or biological system is examined.</rdfs:comment>
    <rdfs:subClassOf rdf:resource="#ExperimentDesignType"/>
  </owl:Class>
  <owl:Class rdf:ID="BioMaterial">
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:onProperty rdf:resource="#has_type"/>
        <owl:someValuesFrom rdf:resource="#MaterialType"/>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:onProperty>
          <owl:ObjectProperty rdf:ID="has_biomaterial_characteristics"/>
        </owl:onProperty>
        <owl:someValuesFrom rdf:resource="#BioMaterialCharacteristics"/>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:label>BioMaterial</rdfs:label>
    <rdfs:subClassOf rdf:resource="#BioMaterialPackage"/>
    <rdfs:comment>Description of the processing state of the biomaterial for use in the microarray hybridization.</rdfs:comment>
  </owl:Class>
  <owl:Class rdf:ID="EnvironmentalStress">
    <rdfs:label>EnvironmentalStress</rdfs:label>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:onProperty rdf:resource="#has_measurement"/>
        <owl:someValuesFrom rdf:resource="#Measurement"/>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:subClassOf rdf:resource="#MGEDExtendedOntology"/>
    <rdfs:comment>Environmental stress is a treatment where some aspect of the environment is perturbed in order to stress the organism or culture, e.g. temperature shock, osmotic shock</rdfs:comment>
  </owl:Class>
  <owl:Class rdf:ID="Organism">
    <rdfs:comment>The genus and species (and subspecies) of the organism from which the biomaterial is derived from. </rdfs:comment>
    <rdfs:subClassOf rdf:resource="#OntologyEntry"/>
    <rdfs:subClassOf rdf:resource="#BioMaterialCharacteristics"/>
    <rdfs:label>Organism</rdfs:label>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:onProperty rdf:resource="#has_database"/>
        <owl:someValuesFrom rdf:resource="#OrganismDatabase"/>
      </owl:Restriction>
    </rdfs:subClassOf>
  </owl:Class>
  <owl:Class rdf:ID="HigherLevelAnalysisPackage">
    <rdfs:subClassOf rdf:resource="#MGEDCoreOntology"/>
    <rdfs:label>HigherLevelAnalysisPackage</rdfs:label>
    <rdfs:comment>MAGE package for HigherLevelAnalysis</rdfs:comment>
  </owl:Class>
  <owl:Class rdf:ID="BioSourceProvider">
    <rdfs:label>BioSourceProvider</rdfs:label>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:onProperty>
          <owl:FunctionalProperty rdf:about="#has_donor"/>
        </owl:onProperty>
        <owl:someValuesFrom rdf:resource="#Organization"/>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:subClassOf rdf:resource="#BioMaterialCharacteristics"/>
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:onProperty>
          <owl:ObjectProperty rdf:about="#has_owner"/>
        </owl:onProperty>
        <owl:someValuesFrom rdf:resource="#Person"/>
      </owl:Restriction>
    </rdfs:subClassOf>
    <rdfs:comment>The resource (e.g, company, hospital, geographical location) used to obtain or purchase the biomaterial. </rdfs:comment>
  </owl:Class>
  <owl:ObjectProperty rdf:ID="has_accession">
    <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#FunctionalProperty"/>
  </owl:ObjectProperty>
  <owl:ObjectProperty rdf:ID="has_image_format">
    <rdfs:domain rdf:resource="#PhysicalBioAssay"/>
    <rdfs:comment>property indicating that the class has an image format</rdfs:comment>
    <rdfs:label>has_image_format</rdfs:label>
  </owl:ObjectProperty>
  <owl:ObjectProperty rdf:ID="has_initial_time_point">
    <rdfs:comment>property indicating that the class has an individual time point</rdfs:comment>
    <rdfs:label>has_initial_time_point</rdfs:label>
    <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#FunctionalProperty"/>
    <rdfs:domain rdf:resource="#Age"/>
  </owl:ObjectProperty>
  <owl:ObjectProperty rdf:ID="has_issue">
    <rdfs:comment>property indicating that the class has an issue</rdfs:comment>
    <rdfs:label>has_issue</rdfs:label>
    <rdfs:domain rdf:resource="#BibliographicReference"/>
  </owl:ObjectProperty>
  <owl:ObjectProperty rdf:ID="has_measurement_type">
    <rdfs:domain rdf:resource="#Measurement"/>
    <rdfs:comment>property indicating that the class has a measurement type</rdfs:comment>
    <rdfs:label>has_measurement_type</rdfs:label>
  </owl:ObjectProperty>
  <owl:ObjectProperty rdf:ID="has_maximum_measurement">
    <rdfs:comment>property indicating that the class has a maximum measurement</rdfs:comment>
    <rdfs:domain rdf:resource="#Age"/>
    <rdfs:label>has_maximum_measurement</rdfs:label>
  </owl:ObjectProperty>
  <owl:ObjectProperty rdf:ID="has_pages">
    <rdfs:domain rdf:resource="#BibliographicReference"/>
    <rdfs:comment>property indicating that the class has pages</rdfs:comment>
    <rdfs:label>has_pages</rdfs:label>
  </owl:ObjectProperty>
  <owl:ObjectProperty rdf:ID="has_volume">
    <rdfs:comment>property indicating that the class has a volume</rdfs:comment>
    <rdfs:domain rdf:resource="#BibliographicReference"/>
    <rdfs:label>has_volume</rdfs:label>
  </owl:ObjectProperty>
  <owl:ObjectProperty rdf:ID="has_host">
    <rdfs:domain rdf:resource="#Host"/>
    <rdfs:label>has_host</rdfs:label>
    <rdfs:comment>property indicating that the class has a host</rdfs:comment>
  </owl:ObjectProperty>
  <owl:ObjectProperty rdf:ID="has_biosource_type">
    <rdfs:domain rdf:resource="#BioSourceProvider"/>
    <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#FunctionalProperty"/>
    <rdfs:comment>property indicating that the class has a biosource type</rdfs:comment>
    <rdfs:label>has_biosource_type</rdfs:label>
  </owl:ObjectProperty>
  <owl:ObjectProperty rdf:ID="has_make">
    <rdfs:comment>property indicating that the class has a make</rdfs:comment>
    <rdfs:domain rdf:resource="#Hardware"/>
    <rdfs:label>has_make</rdfs:label>
  </owl:ObjectProperty>
  <owl:ObjectProperty rdf:ID="has_model">
    <rdfs:comment>property indicating that the class has a model</rdfs:comment>
    <rdfs:label>has_model</rdfs:label>
    <rdfs:domain rdf:resource="#Hardware"/>
  </owl:ObjectProperty>
  <owl:ObjectProperty rdf:ID="has_owner">
    <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#FunctionalProperty"/>
  </owl:ObjectProperty>
  <owl:ObjectProperty rdf:ID="has_value">
    <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#FunctionalProperty"/>
  </owl:ObjectProperty>
  <owl:ObjectProperty rdf:ID="has_host_part">
    <rdfs:domain rdf:resource="#Host"/>
    <rdfs:label>has_host_part</rdfs:label>
    <rdfs:comment>property indicating that the class has a host part</rdfs:comment>
  </owl:ObjectProperty>
  <owl:ObjectProperty rdf:ID="has_laboratory_test"/>
  <owl:FunctionalProperty rdf:ID="has_accession_version">
    <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#ObjectProperty"/>
  </owl:FunctionalProperty>
  <owl:FunctionalProperty rdf:ID="has_URI">
    <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#ObjectProperty"/>
  </owl:FunctionalProperty>
  <owl:FunctionalProperty rdf:ID="has_been_treated">
    <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#ObjectProperty"/>
  </owl:FunctionalProperty>
  <owl:FunctionalProperty rdf:ID="has_donor">
    <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#ObjectProperty"/>
  </owl:FunctionalProperty>
  <PhysicalBioSequenceType rdf:ID="ds_oligo">
    <rdfs:comment> a double stranded oligonucleotide</rdfs:comment>
  </PhysicalBioSequenceType>
  <LabelCompound rdf:ID="alexa_633"/>
  <DatabaseEntryType rdf:ID="microarray_experiment_record">
    <rdfs:comment>A record which describes and identifies a microarray experiment e.g. GEO</rdfs:comment>
  </DatabaseEntryType>
  <RadiationUnit rdf:ID="cpm">
    <rdfs:comment>counts per minute, unit of light emissions produced by ionizing radiation.</rdfs:comment>
  </RadiationUnit>
  <NormalizationDescriptionType rdf:ID="ratio_statistics_normalization"/>
  <DataType rdf:ID="string_datatype">
    <rdfs:comment>The values are a sequence of one or more characters.</rdfs:comment>
  </DataType>
  <ConcentrationUnitOther rdf:ID="mg_kg_day"/>
  <FamilyRelationship rdf:ID="aunt">
    <rdfs:comment>The sister of one's father or mother.</rdfs:comment>
  </FamilyRelationship>
  <Sex rdf:ID="hermaphrodite">
    <rdfs:comment>an organism with both male and female sexual organs in one individual</rdfs:comment>
  </Sex>
  <DevelopmentalStageDatabase rdf:ID="EMAP">
    <has_URI>
      <owl:Thing rdf:ID="http___genex.hgu.mrc.ac.uk"/>
    </has_URI>
    <rdfs:comment>The Edinburgh Mouse Atlas Project (EMAP) ontology of mouse developmental anatomy covers the 26 developmental stages (Theiler Stages) from fertilization to birth.</rdfs:comment>
  </DevelopmentalStageDatabase>
  <ProtocolType rdf:ID="PCR_amplification">
    <rdf:type rdf:resource="#ComplexAction"/>
    <rdfs:comment>Amplification of nucleic acid sequence by use of the polymerase chain reaction whereby the number of templates grows geometrically with each cycle. </rdfs:comment>
  </ProtocolType>
  <SurfaceType rdf:ID="unknown_surface_type">
    <rdfs:comment>A SurfaceType of unknown type.</rdfs:comment>
  </SurfaceType>
  <TheoreticalBioSequenceType rdf:ID="consensus_DNA"/>
  <URI rdf:ID="http___www.geneontology.org_gobo_anatomy.ontology_adult_mouse_anatomy"/>
  <DerivedBioAssayType rdf:ID="averaged_intensity">
    <rdfs:comment>results of data reduction involving computation of the average intensity from identical Features, Reporters or CompositeSequences in different hybridizations.</rdfs:comment>
  </DerivedBioAssayType>
  <MassUnit rdf:ID="pg">
    <rdfs:comment>picogram, mass unit</rdfs:comment>
  </MassUnit>
  <ControlType rdf:ID="control_spike_calibration"/>
  <QualityControlDescriptionType rdf:ID="peer_review_quality_control">
    <rdfs:comment>An experiment which has a peer reviewed publication attached.</rdfs:comment>
  </QualityControlDescriptionType>
  <DistanceUnit rdf:ID="m"/>
  <ChromosomalAberrationClassification rdf:ID="chromosomal_translocation">
    <rdfs:comment>A type of aberration characterized by fragmentation of a chromosome and transfer of the broken-off portion to another chromosome, often of a different pair.</rdfs:comment>
  </ChromosomalAberrationClassification>
  <StrainOrLineDatabase rdf:ID="JAX_mouse_strains">
    <has_URI>
      <owl:Thing rdf:ID="http___www.informatics.jax.org_external_festing_mouse_STRAINS.shtml"/>
    </has_URI>
    <rdfs:comment>Database entry from the resource at The Jackson Laboratory which has details of approved mouse strain nomenclature.</rdfs:comment>
  </StrainOrLineDatabase>
  <ProtocolType rdf:ID="starvation">
    <rdfs:comment>Depriving an organism of food or nutrients</rdfs:comment>
    <rdf:type rdf:resource="#ComplexAction"/>
  </ProtocolType>
  <MaterialType rdf:ID="virus">
    <rdfs:comment>one or more DNA or RNA based non cellular infective agent, including bacteriophage</rdfs:comment>
  </MaterialType>
  <MaterialType rdf:ID="total_RNA">
    <rdfs:comment>Total cellular and nuclear RNA.</rdfs:comment>
  </MaterialType>
  <LabelCompound rdf:ID="alexa_532"/>
  <ProtocolType rdf:ID="dissect">
    <rdfs:comment>The action of removing one or more OrganismParts.</rdfs:comment>
    <rdf:type rdf:resource="#ComplexAction"/>
  </ProtocolType>
  <ConcentrationUnitOther rdf:ID="percent_confluence"/>
  <EnvironmentalFactorCategory rdf:ID="water">
    <rdfs:comment>Water consumed by or enveloping the organism that the biosource is derived from. </rdfs:comment>
  </EnvironmentalFactorCategory>
  <PhysicalBioSequenceType rdf:ID="PCR_primer_forward"/>
  <SubstrateType rdf:ID="silicon">
    <rdfs:comment>the array is made on silicon </rdfs:comment>
  </SubstrateType>
  <BioMaterialCharacteristicCategory rdf:ID="clinical_treatment">
    <rdfs:comment>A descriptor for a clinical treatment for a patient.</rdfs:comment>
  </BioMaterialCharacteristicCategory>
  <DataType rdf:ID="nonnegative_float">
    <rdfs:comment>A float greater than or equal to 0.</rdfs:comment>
  </DataType>
  <FamilyRelationship rdf:ID="mother">
    <rdfs:comment>A female parent.</rdfs:comment>
  </FamilyRelationship>
  <ProtocolType rdf:ID="decontaminate">
    <rdf:type rdf:resource="#ComplexAction"/>
  </ProtocolType>
  <DataType rdf:ID="nonnegative_integer">
    <rdfs:comment>An integer >= 0.</rdfs:comment>
  </DataType>
  <TimeUnit rdf:ID="seconds">
    <rdfs:comment>time unit</rdfs:comment>
  </TimeUnit>
  <PerturbationalDesign rdf:ID="cellular_modification_design">
    <rdfs:comment>A cellular modification design type is where a modification of the transcriptome, proteome (not genome) is made, for example RNAi, antibody targeting. </rdfs:comment>
  </PerturbationalDesign>
  <AtomicAction rdf:ID="set_temperature">
    <rdfs:comment>An action where the temperature is specified.  </rdfs:comment>
  </AtomicAction>
  <owl:Thing rdf:ID="http___www.gramene.org_"/>
  <Ploidy rdf:ID="polyploid">
    <rdfs:comment>Describes a cell, nucleus or organism with three or more copies of each chromosome.</rdfs:comment>
  </Ploidy>
  <DesignElementGroupType rdf:ID="species_specific_design_element_group_type">
    <rdfs:comment>A grouping of DesignElements, Features, Reporters, Composite Sequences on the basis of a common species.</rdfs:comment>
  </DesignElementGroupType>
  <LabelCompound rdf:ID="alexa_430"/>
  <StrandType rdf:ID="reverse"/>
  <DefectType rdf:ID="missing_feature_or_zone">
    <rdfs:comment>The source DNA was not printed for a Feature or Zone on the slide, possibly due to lack of sample, broken or clogged spotting pin.</rdfs:comment>
  </DefectType>
  <ProtocolType rdf:ID="purify">
    <rdfs:comment>The action of enriching a BioMaterial  (organism, cell, nucleic acid etc) or Compound e.g. for FACS for positive selection  or RNA  cleanup the Action or ProtocolType is purify (see fractionate). </rdfs:comment>
    <rdf:type rdf:resource="#ComplexAction"/>
  </ProtocolType>
  <URI rdf:ID="http___www.iupac.org_publications_pac_2000_7205_7205olesen.html"/>
  <BioSourceType rdf:ID="blood">
    <rdfs:comment>A biomaterial obtained as fluid consisting of plasma, blood cells and platelets.</rdfs:comment>
  </BioSourceType>
  <TheoreticalBioSequenceType rdf:ID="EST"/>
  <SeqFeatureBasis rdf:ID="computational_feature">
    <rdfs:comment>Computationally derived sequence feature.</rdfs:comment>
  </SeqFeatureBasis>
  <TheoreticalBioSequenceType rdf:ID="ORF">
    <rdfs:comment>sequence which represents an open reading frame, a series of codon triplets deduced from a DNA sequence, that contain a start and a stop codon.</rdfs:comment>
  </TheoreticalBioSequenceType>
  <URI rdf:ID="http___www.opengalen.org_open_crm_crm-anatomy.html"/>
  <DesignElementGroupType rdf:ID="control_design_element_group_type">
    <rdfs:comment>A grouping of DesignElements features/Reporters/Composites which are not designed to detect a signal in the biomaterial and which are on the array for control purposes e.g a grouping of controls used for spiking.</rdfs:comment>
  </DesignElementGroupType>
  <ComplexAction rdf:ID="preservation">
    <rdfs:comment>The type of protocol used to preserve (including storage or keep in statis) the biomaterial.</rdfs:comment>
    <rdf:type rdf:resource="#ProtocolType"/>
  </ComplexAction>
  <OrganismStatus rdf:ID="postmortem">
    <rdfs:comment>biomaterial removed after the death of the organism</rdfs:comment>
  </OrganismStatus>
  <DataType rdf:ID="list_of_integer">
    <rdfs:comment>An ordered, finite set of integers.</rdfs:comment>
  </DataType>
  <DerivedBioAssayType rdf:ID="clustered_data">
    <rdfs:comment>results of an analysis method that groups data based on some measure of similarity, e.g. Pearson correlation coeficient, Euclidean distance. </rdfs:comment>
  </DerivedBioAssayType>
  <Sex rdf:ID="Hfr"/>
  <DistanceUnit rdf:ID="um">
    <rdfs:comment>micrometer, unit of distance</rdfs:comment>
  </DistanceUnit>
  <TheoreticalBioSequenceType rdf:ID="consensus_mRNA">
    <rdfs:comment>mRNA sequence produced from some base calling or alignment algorithm which uses aligned or assembled multiple sequences as input.</rdfs:comment>
  </TheoreticalBioSequenceType>
  <ChromosomalAberrationClassification rdf:ID="monosomy">
    <rdfs:comment>Absence of one chromosome of a pair of homologous chromosomes. In a normally diploid cell it is represented symbolically as 2N-1.</rdfs:comment>
  </ChromosomalAberrationClassification>
  <DerivedBioAssayType rdf:ID="mean_and_coefficient_of_variation">
    <rdfs:comment>the mean and coefficient of variation values resulting from computationally combining 2 or more sets of BioAssayData</rdfs:comment>
  </DerivedBioAssayType>
  <CompoundDatabase rdf:ID="ChemID">
    <rdfs:comment>Database entry from the ChemIDplus database which stores information on the structure, identifiers etc for compounds.</rdfs:comment>
    <has_URI>
      <URI rdf:ID="http___chem.sis.nlm.nih.gov_chemidplus"/>
    </has_URI>
  </CompoundDatabase>
  <LabelCompound rdf:ID="_33P"/>
  <PublicationType rdf:ID="journal_article">
    <rdfs:comment>A article published in a print or online journal having an ISSN.</rdfs:comment>
  </PublicationType>
  <ControlType rdf:ID="control_reporter_size">
    <rdfs:comment>A Reporter of whose BioSequence is of known length used as a methodological control for hybridization efficiency.</rdfs:comment>
  </ControlType>
  <DeliveryMethod rdf:ID="intravenous">
    <rdfs:comment>delivery method whereby a compound or drug is administered via a vein</rdfs:comment>
  </DeliveryMethod>
  <NormalizationDescriptionType rdf:ID="replicate_analysis"/>
  <DataType rdf:ID="integer">
    <rdfs:comment>A value which is a whole number (e.g. 10).</rdfs:comment>
  </DataType>
  <Sex rdf:ID="mixed_sex">
    <rdfs:comment>A population of multiple sexes, e.g. a mixture of females and males, or males and hermaphrodites.</rdfs:comment>
  </Sex>
  <GeneticModification rdf:ID="gene_knock_in">
    <rdfs:comment>The modification of an organism that inserts a functional gene at the site of a nonfunctional locus for that gene using recombinant methods.</rdfs:comment>
  </GeneticModification>
  <MassUnit rdf:ID="ug">
    <rdfs:comment>microgram, unit of mass</rdfs:comment>
  </MassUnit>
  <PhysicalBioSequenceType rdf:ID="plasmid">
    <rdfs:comment>sequence from a plasmid, an extrachromosomal autonomously replicating piece of DNA excluding mitochondria and chloroplasts </rdfs:comment>
  </PhysicalBioSequenceType>
  <NormalizationDescriptionType rdf:ID="total_intensity_normalization"/>
  <ProtocolType rdf:ID="store">
    <rdfs:comment>The procedure of placing a physical object under specified conditions e.g. time, temperature, humidity, for the purposes of keeping it in the same state.</rdfs:comment>
    <rdf:type rdf:resource="#ComplexAction"/>
  </ProtocolType>
  <VolumeUnit rdf:ID="L">
    <rdfs:comment>liter, unit of volume</rdfs:comment>
  </VolumeUnit>
  <DerivedBioAssayType rdf:ID="mean_and_standard_deviation">
    <rdfs:comment>the mean and standard deviation values resulting from computationally combining 2 or more sets of BioAssayData</rdfs:comment>
  </DerivedBioAssayType>
  <LabelCompound rdf:ID="alexa_488"/>
  <PerturbationalDesign rdf:ID="genetic_modification_design">
    <rdfs:comment>A genetic modification design type is where an organism(s) has had genetic material removed, rearranged, mutagenized or added, such as knock out</rdfs:comment>
  </PerturbationalDesign>
  <ControlType rdf:ID="control_genomic_DNA">
    <rdfs:comment>A Reporter where genomic DNA has been deposited, the genomic DNA may be fragmented, e.g. salmon sperm DNA, Cot1DNA. </rdfs:comment>
  </ControlType>
  <URI rdf:ID="ftp___ftp.cdc.gov_pub_Health_Statistics_NCHS_Publications_ICD9-CM_2002_"/>
  <PhysicalBioSequenceType rdf:ID="PCR_amplicon">
    <rdfs:comment>BioSequence generated by means of polymerase chain reaction</rdfs:comment>
  </PhysicalBioSequenceType>
  <DatabaseEntryType rdf:ID="curated_amino_acid_sequence_record">
    <rdfs:comment>A record which describes and identifies an amino acid sequence which has been curated</rdfs:comment>
  </DatabaseEntryType>
  <SeqFeatureBasis rdf:ID="experimental_feature">
    <rdfs:comment>An experimentally defined sequence feature.</rdfs:comment>
  </SeqFeatureBasis>
  <SubstrateType rdf:ID="nitrocellulose">
    <rdfs:comment>The array is made on a nitrocellulose  filter.</rdfs:comment>
  </SubstrateType>
  <DiseaseStateDatabase rdf:ID="NCI_Thesaurus">
    <rdf:type rdf:resource="#StrainOrLineDatabase"/>
    <rdf:type rdf:resource="#CompoundDatabase"/>
    <rdfs:comment></rdfs:comment>
    <rdf:type rdf:resource="#GeographicLocationDatabase"/>
    <rdf:type rdf:resource="#OrganismPartDatabase"/>
    <rdf:type rdf:resource="#ChromosomalAberrationDatabase"/>
    <rdf:type rdf:resource="#TargetedCellTypeDatabase"/>
    <has_URI>
      <owl:Thing rdf:ID="http___nciterms.nci.nih.gov"/>
    </has_URI>
    <rdf:type rdf:resource="#CellTypeDatabase"/>
  </DiseaseStateDatabase>
  <DerivedBioAssayType rdf:ID="mean_and_variance">
    <rdfs:comment>the mean and variance values resulting from computationally combining 2  or more sets of BioAssayData</rdfs:comment>
  </DerivedBioAssayType>
  <FeatureShape rdf:ID="ellipsoid_feature">
    <rdfs:comment>The shape of the feature on the array is circular or oval.</rdfs:comment>
  </FeatureShape>
  <ProtocolType rdf:ID="unknown_protocol_type">
    <rdfs:comment>ProtocolType of unknown type.</rdfs:comment>
  </ProtocolType>
  <LabelCompound rdf:ID="alexa_594"/>
  <DataType rdf:ID="list_of_string">
    <rdfs:comment>An ordered, finite set of strings.</rdfs:comment>
  </DataType>
  <BiologicalProperty rdf:ID="strain_or_line_design">
    <rdfs:comment>A strain or line experiment design type assays differences between multiple strains, cultivars, serovars, isolates, lines from organisms of a single species.</rdfs:comment>
  </BiologicalProperty>
  <TheoreticalBioSequenceType rdf:ID="intergenic"/>
  <SoftwareType rdf:ID="clustering_software">
    <rdfs:comment>Software used to cluster the data.</rdfs:comment>
  </SoftwareType>
  <FamilyRelationship rdf:ID="son">
    <rdfs:comment>The male offspring of the patient or individual under study.</rdfs:comment>
  </FamilyRelationship>
  <BioMaterialCharacteristicCategory rdf:ID="age">
    <rdfs:comment>A descriptor for FactorValue where age is compared.</rdfs:comment>
  </BioMaterialCharacteristicCategory>
  <AtomicAction rdf:ID="resuspend">
    <rdfs:comment>The procedure in which solid material is dispensed or dissolved in a liquid.</rdfs:comment>
  </AtomicAction>
  <OrganismPartDatabase rdf:ID="FMA">
    <rdfs:comment>The Foundational Model of Anatomy (FMA) is  concerned with the representation of concepts and relationships necessary for the symbolic modeling of the structure of the human body.</rdfs:comment>
    <has_URI>
      <URI rdf:ID="http___sig.biostr.washington.edu_projects_fm_"/>
    </has_URI>
  </OrganismPartDatabase>
  <AtomicAction rdf:ID="place">
    <rdfs:comment>The procedure of putting a physical object in a container/physical space.</rdfs:comment>
  </AtomicAction>
  <ProtocolType rdf:ID="labeling">
    <rdfs:comment>The procedure of labeling a biosample.</rdfs:comment>
    <rdf:type rdf:resource="#ComplexAction"/>
  </ProtocolType>
  <DeliveryMethod rdf:ID="intraperitoneal_injection">
    <rdfs:comment>A delivery method for compound or drug whereby the substance is administered via the peritoneum.</rdfs:comment>
  </DeliveryMethod>
  <OrganismPartDatabase rdf:ID="FlyBase">
    <has_URI>
      <owl:Thing rdf:ID="http___cvs.sourceforge.net_cgi-bin_viewcvs.cgi_obo_obo_ontology_anatomy_gross_anatomy_animal_gross_anatomy_fly_"/>
    </has_URI>
    <rdfs:comment>curated database containing information on Drosophila genes, alleles etc</rdfs:comment>
  </OrganismPartDatabase>
  <Roles rdf:ID="software_manufacturer">
    <rdfs:comment>Person or organization that manufactured the software.</rdfs:comment>
  </Roles>
  <HardwareType rdf:ID="centrifuge"/>
  <HardwareType rdf:ID="sonicator">
    <rdfs:comment>An instrument for sonicating biomaterials.</rdfs:comment>
  </HardwareType>
  <FamilyRelationship rdf:ID="grandfather">
    <rdfs:comment>The father of one's father or mother.</rdfs:comment>
  </FamilyRelationship>
  <AtomicAction rdf:ID="mix_by_pipette">
    <rdfs:comment>Mix by drawing up and down with a pipette.</rdfs:comment>
  </AtomicAction>
  <ComplexAction rdf:ID="reverse_transcription">
    <rdfs:comment>Generation of a DNA strand from an RNA strand using reverse transcriptase.</rdfs:comment>
    <rdf:type rdf:resource="#ProtocolType"/>
  </ComplexAction>
  <PreservationType rdf:ID="frozen_storage">
    <rdfs:comment>Storage where the thing stored is stored below 0 degrees celsius.</rdfs:comment>
  </PreservationType>
  <TechnologyType rdf:ID="spotted_antibody_features">
    <rdfs:comment>TechnologyType of FeatureGroup where antibodies are spotted directly.</rdfs:comment>
  </TechnologyType>
  <SubstrateType rdf:ID="unknown_substrate_type">
    <rdfs:comment>SubstrateType of unknown type.</rdfs:comment>
  </SubstrateType>
  <PerturbationalDesign rdf:ID="dose_response_design">
    <rdfs:comment>A dose response design type examines the relationship between the size of the administered dose and the extent of the response of the organism(s). </rdfs:comment>
  </PerturbationalDesign>
  <TimeUnit rdf:ID="hours">
    <rdfs:comment>60 minutes, time unit</rdfs:comment>
  </TimeUnit>
  <BiologicalProperty rdf:ID="is_expressed_design">
    <rdfs:comment>A design aimed at identifying genes expressed in biomaterials of interest. </rdfs:comment>
  </BiologicalProperty>
  <VolumeUnit rdf:ID="ml">
    <rdfs:comment>milliliter, volume unit</rdfs:comment>
  </VolumeUnit>
  <WarningType rdf:ID="is_contaminated">
    <rdfs:comment>The clone used to originate the BioSequence which corresponds to the reporter was found to be contaminated (e.g. well-well contamination) on examination.</rdfs:comment>
  </WarningType>
  <MethodologicalDesign rdf:ID="self_vs_self_design">
    <rdfs:comment>A self vs. self experiment design investigates variance and error estimates in the experimental system, and is where the same extract is compared. </rdfs:comment>
  </MethodologicalDesign>
  <FiducialType rdf:ID="chrome_border"/>
  <SubstrateType rdf:ID="nylon">
    <rdfs:comment>The array is made on a nylon membrane.</rdfs:comment>
  </SubstrateType>
  <InitialTimePoint rdf:ID="planting">
    <rdfs:comment>time point at which a seed was planted</rdfs:comment>
  </InitialTimePoint>
  <ChromosomalAberrationClassification rdf:ID="trisomy">
    <rdfs:comment>The possession of a third chromosome of any one type in an otherwise diploid cell.</rdfs:comment>
  </ChromosomalAberrationClassification>
  <LabelCompound rdf:ID="alexa_546"/>
  <HardwareType rdf:ID="hybridization_station">
    <rdfs:comment>An instrument which controls hybridization conditions, into which a hybridization chamber may fit.</rdfs:comment>
  </HardwareType>
  <EnvironmentalFactorCategory rdf:ID="atmosphere">
    <rdfs:comment>The atmospheric conditions used to culture or grow an organism.</rdfs:comment>
  </EnvironmentalFactorCategory>
  <TechnologyType rdf:ID="spotted_ds_DNA_features">
    <rdfs:comment>A descriptor for the TechnologyType for a group of features where double stranded DNA is spotted on the array e.g. a PCR of a cDNA clone.</rdfs:comment>
  </TechnologyType>
  <QuantityUnitOther rdf:ID="count">
    <rdfs:comment>Unit for a simple count of things</rdfs:comment>
  </QuantityUnitOther>
  <DataType rdf:ID="positive_float">
    <rdfs:comment>A float > 0.</rdfs:comment>
  </DataType>
  <owl:Thing rdf:ID="http___hazel.niehs.nih.gov_user_spt_pct_terms.htm"/>
  <SoftwareType rdf:ID="array_manufacture_software"/>
  <TheoreticalBioSequenceType rdf:ID="gene">
    <rdfs:comment>genomic sequence which corresponds to the primary transcript and uses the furthest 5' and 3'  UTR's, doesn't include non transcribed regulatory regions. Can be experimentally or computationally determined</rdfs:comment>
  </TheoreticalBioSequenceType>
  <ControlType rdf:ID="control_buffer">
    <rdfs:comment>A Reporter where only buffer was deposited on the array</rdfs:comment>
  </ControlType>
  <Sex rdf:ID="female"/>
  <BioMaterialCharacteristicCategory rdf:ID="organism">
    <rdfs:comment>one or more of any unicellular or multicellular pro or eukaryote, including archaebacteria</rdfs:comment>
  </BioMaterialCharacteristicCategory>
  <ConcentrationUnit rdf:ID="mM">
    <rdfs:comment>milimolar, concentration unit</rdfs:comment>
  </ConcentrationUnit>
  <HardwareType rdf:ID="computer"/>
  <EnvironmentalFactorCategory rdf:ID="barrier_facility">
    <rdfs:comment>The rating of containment system used to protect organisms from infectious agents.</rdfs:comment>
  </EnvironmentalFactorCategory>
  <LabelCompound rdf:ID="alexa_350"/>
  <TimeUnit rdf:ID="days">
    <rdfs:comment>24 hours, time unit</rdfs:comment>
  </TimeUnit>
  <TechnologyType rdf:ID="in_situ_oligo_features">
    <rdfs:comment>The TechnologyType of the FeatureGroup  is manufactured using in situ methods such as photolithography (e.g. Affymetrix) or chemical synthesis (e.g. Agilent)</rdfs:comment>
  </TechnologyType>
  <DistanceUnit rdf:ID="A">
    <rdfs:comment>Angstrom, unit of distance, 1 angstrom = 10 nanometers</rdfs:comment>
  </DistanceUnit>
  <SeqFeatureBasis rdf:ID="experimental_and_computational_feature">
    <rdfs:comment>Sequence features derived by both computational and experimental methods.</rdfs:comment>
  </SeqFeatureBasis>
  <ChromosomalAberrationClassification rdf:ID="chromosomal_insertion">
    <rdfs:comment>The gain of a segment of the genetic material in a chromosome by fragmentation of a chromosome and transfer of the broken-off portion of another chromosome or other sources.</rdfs:comment>
  </ChromosomalAberrationClassification>
  <MethodologicalDesign rdf:ID="operator_variation_design">
    <rdfs:comment>An operator variation experiment design type assesses the operator performance and relation to data consistency and quality.</rdfs:comment>
  </MethodologicalDesign>
  <Roles rdf:ID="funder">
    <rdfs:comment>Contact which provides funding for experiments.</rdfs:comment>
  </Roles>
  <owl:Thing rdf:ID="http___www.nlm.nih.gov_mesh_filelist.html"/>
  <QualityControlDescriptionType rdf:ID="dye_swap_quality_control">
    <rdfs:comment>Indicates that a dye swap was performed for some or all hybridizations within an experiment </rdfs:comment>
  </QualityControlDescriptionType>
  <SeqFeatureBasis rdf:ID="unknown_basis_feature">
    <rdfs:comment>Sequence feature whose derivation is unknown.</rdfs:comment>
  </SeqFeatureBasis>
  <ConcentrationUnit rdf:ID="mg_mL"/>
  <BiologicalProperty rdf:ID="individual_genetic_characteristics_design">
    <rdfs:comment>An experiment design type where genotype, haplotype, or other individual genetic characteristics are compared.</rdfs:comment>
  </BiologicalProperty>
  <DesignElementGroupType rdf:ID="mixed_design_element_group_type">
    <rdfs:comment>a designelement group consisting of multiple types </rdfs:comment>
  </DesignElementGroupType>
  <DatabaseEntryType rdf:ID="ontology_record">
    <rdfs:comment>A record which describes and identifies a term, class or instance in an ontology or controlled vocabulary e.g. ICD</rdfs:comment>
  </DatabaseEntryType>
  <TheoreticalBioSequenceType rdf:ID="polypeptide">
    <rdfs:comment>sequence of a protein, a linear amino acid polymer</rdfs:comment>
    <rdf:type rdf:resource="#PhysicalBioSequenceType"/>
  </TheoreticalBioSequenceType>
  <NormalizationDescriptionType rdf:ID="slice_analysis">
    <rdfs:comment>A method of analyzing the significant expression level of a Feature by calculating the  intensity-dependent Z distribution value for the logarithm of the intensity ratios from the  two channels.</rdfs:comment>
  </NormalizationDescriptionType>
  <BioMolecularAnnotation rdf:ID="transcript_identification_design">
    <rdfs:comment>A transcript identification design type characterizes the length and position of transcripts and allows identification of all forms of  transcripts in the genome.</rdfs:comment>
  </BioMolecularAnnotation>
  <DerivedBioAssayType rdf:ID="signal">
    <rdfs:comment>A quantitative measure of the relative abundance of a transcript (MAS 4.0 version of the Affymetrix analysis software).</rdfs:comment>
  </DerivedBioAssayType>
  <PhysicalBioSequenceType rdf:ID="unknown_sequence">
    <rdfs:comment>BioSequence of unknown type</rdfs:comment>
    <rdf:type rdf:resource="#TheoreticalBioSequenceType"/>
  </PhysicalBioSequenceType>
  <DatabaseEntryType rdf:ID="function_record">
    <rdfs:comment>a record which identifies and describes the function of a gene product, e.g. E.C. record</rdfs:comment>
  </DatabaseEntryType>
  <BiologicalProperty rdf:ID="circadian_rhythm_design">
    <rdfs:comment>A circadian rhythm experiment design type assays the events associated with the circadian rhythm which is a biological activity that exhibits an endogenous periodicity independently of any daily variation in the environment.</rdfs:comment>
  </BiologicalProperty>
  <URI rdf:ID="http___www.loinc.org_download"/>
  <HardwareType rdf:ID="waterbath">
    <rdfs:comment>A device for controlling temperature by immersion in water.</rdfs:comment>
  </HardwareType>
  <DataType rdf:ID="discrete">
    <rdfs:comment></rdfs:comment>
  </DataType>
  <ConcentrationUnit rdf:ID="g_L"/>
  <Scale rdf:ID="unscaled">
    <rdfs:comment>The values are unordered and have no scale.</rdfs:comment>
  </Scale>
  <DataType rdf:ID="list_of_nonpositive_float">
    <rdfs:comment>An ordered, finite set of nonpositive floats.</rdfs:comment>
  </DataType>
  <MaterialType rdf:ID="synthetic_RNA"/>
  <EpidemiologicalDesign rdf:ID="family_history_design">
    <rdfs:comment>A family history design type is where the family history such as traits, characteristics, susceptibility to disease is studied</rdfs:comment>
  </EpidemiologicalDesign>
  <ChromosomalAberrationClassification rdf:ID="ploidy">
    <rdfs:comment>A chromosomal abnormality in which there are extra complete multiples.</rdfs:comment>
  </ChromosomalAberrationClassification>
  <EnvironmentalFactorCategory rdf:ID="media">
    <rdfs:comment>The physical state or matrix used to provide nutrients to the organism (e.g., liquid, agar, soil) </rdfs:comment>
  </EnvironmentalFactorCategory>
  <DatabaseEntryType rdf:ID="compound_record">
    <rdfs:comment>a record which describes and identifies a compound e.g. drug record part of NCI thesaurus</rdfs:comment>
  </DatabaseEntryType>
  <LabelCompound rdf:ID="alexa_660"/>
  <BioMaterialCharacteristicCategory rdf:ID="cell_type">
    <rdfs:comment>A descriptor for FactorValue where CellType is compared.  </rdfs:comment>
  </BioMaterialCharacteristicCategory>
  <AtomicAction rdf:ID="change_light">
    <rdfs:comment>Change in light intensity or wavelength. </rdfs:comment>
  </AtomicAction>
  <PhysicalBioSequenceType rdf:ID="vector">
    <rdfs:comment>Sequence from a vector, DNA of any transmissible agent e.g. plasmid or virus into which a segment of foreign DNA can be spliced, does not include insert sequence. These terms should be used when other terms such as plasmid, YAC, BAC are used.  </rdfs:comment>
  </PhysicalBioSequenceType>
  <NodeValueType rdf:ID="Spearmans_rank_correlation">
    <rdfs:comment>Computed as the ordinary Pearson correlation coefficient between two groups of rankings.</rdfs:comment>
  </NodeValueType>
  <BioMolecularAnnotation rdf:ID="RNA_stability_design">
    <rdfs:comment>A RNA stability experiment design type examines the stability and/or decay of RNA transcripts.</rdfs:comment>
  </BioMolecularAnnotation>
  <Scale rdf:ID="log_base_e">
    <rdfs:comment>The values presented are logarithm, base e.</rdfs:comment>
  </Scale>
  <PerturbationalDesign rdf:ID="compound_treatment_design">
    <rdfs:comment>A compound treatment design type is where the response to administration of a compound or chemical (including biological compounds such as hormones)  is assayed.</rdfs:comment>
  </PerturbationalDesign>
  <BioMaterialCharacteristicCategory rdf:ID="genetic_variation">
    <rdfs:comment>A descriptor for FactorValue where GeneticVariation is compared.  </rdfs:comment>
  </BioMaterialCharacteristicCategory>
  <BioMolecularAnnotation rdf:ID="genotyping_design">
    <rdfs:comment>A genotyping experiment design type classifies an individual or group of individuals on the basis of alleles, haplotypes, SNP's. </rdfs:comment>
  </BioMolecularAnnotation>
  <ChromosomalAberrationClassification rdf:ID="reciprocal_translocation">
    <rdfs:comment>Interchanges of genetic material among different chromosomes such that the total chromosome complement may still contain all of the genetic material.</rdfs:comment>
  </ChromosomalAberrationClassification>
  <HardwareType rdf:ID="hybridization_chamber">
    <rdfs:comment>A chamber in which the hybridization is performed which maintains constant conditions.</rdfs:comment>
  </HardwareType>
  <BioMaterialCharacteristicCategory rdf:ID="cell_line">
    <rdfs:comment>A descriptor for FactorValue where CellLine is compared.  </rdfs:comment>
  </BioMaterialCharacteristicCategory>
  <GeneticModification rdf:ID="induced_mutation">
    <rdfs:comment>The modification of the genetic material (either coding or non-coding) of an organism by mutagenic compounds or irradiation.</rdfs:comment>
  </GeneticModification>
  <MethodologicalDesign rdf:ID="all_pairs">
    <rdfs:comment>An all pairs experiment design type is where all labeled extracts are compared to every other labeled extract.  </rdfs:comment>
  </MethodologicalDesign>
  <MaterialType rdf:ID="whole_organism">
    <rdfs:comment>one or more of any unicellular or multicellular pro or eukaryote, including archaebacteria</rdfs:comment>
  </MaterialType>
  <PerturbationalDesign rdf:ID="stimulus_or_stress_design">
    <rdfs:comment>A stimulus or stress experiment design type is where the response of an organism(s) to the stress or stimulus is studied, e.g. osmotic stress, heat shock, radiation exposure, behavioral treatment etc.</rdfs:comment>
  </PerturbationalDesign>
  <SurfaceType rdf:ID="polylysine">
    <rdfs:comment>A type of surface coating. </rdfs:comment>
  </SurfaceType>
  <DefectType rdf:ID="heavy_background">
    <rdfs:comment>The Zone is excluded due to smearing, streaking, or dense background in the Zone.</rdfs:comment>
  </DefectType>
  <PhysicalBioSequenceType rdf:ID="ss_oligo">
    <rdfs:comment>sequence of a single stranded synthesized oligonucleotide</rdfs:comment>
  </PhysicalBioSequenceType>
  <LightUnit rdf:ID="candela"/>
  <LightUnit rdf:ID="lux">
    <rdfs:comment>A metric unit equal to one lumen per square meter. This unit is the modern equivalent of foot-candles where one footcandle is 10.76 lux.</rdfs:comment>
  </LightUnit>
  <MaterialType rdf:ID="organellar_RNA">
    <rdfs:comment>RNA obtained from an organelle, e.g., mitochondrion, ER, or chloroplast, excluding the nucleus.</rdfs:comment>
  </MaterialType>
  <BiologicalProperty rdf:ID="sex_design">
    <rdfs:comment>A sex experiment design type assays differences associated with an organism's sex, gender or mating type.</rdfs:comment>
  </BiologicalProperty>
  <StrandType rdf:ID="single_stranded">
    <rdfs:comment>a nucleic acid consiting of a single polynucleotide chain.</rdfs:comment>
  </StrandType>
  <MaterialType rdf:ID="synthetic_DNA"/>
  <TechnologyType rdf:ID="spotted_ss_oligo_features">
    <rdfs:comment>The TechnologyType of the FeatureGroup  is spotted single stranded oligonucleotides (of any length) on the substrate.</rdfs:comment>
  </TechnologyType>
  <TheoreticalBioSequenceType rdf:ID="chromosome">
    <rdfs:comment>Physical or theoretical sequence of, or representing a chromosome, one of the DNA molecules that comprises the genome.  </rdfs:comment>
    <rdf:type rdf:resource="#PhysicalBioSequenceType"/>
  </TheoreticalBioSequenceType>
  <DiseaseStateDatabase rdf:ID="MESH">
    <rdfs:comment>database entry from MESH, medical subject headings vocabulary resource</rdfs:comment>
    <has_URI rdf:resource="#http___www.nlm.nih.gov_mesh_filelist.html"/>
  </DiseaseStateDatabase>
  <PhysicalBioSequenceType rdf:ID="mtDNA"/>
  <ConcentrationUnit rdf:ID="gram_percent">
    <rdfs:comment>grams per deciliter, concentration unit</rdfs:comment>
  </ConcentrationUnit>
  <RadiationUnit rdf:ID="dpm">
    <rdfs:comment>disintegrations per minute, unit of atom disintegrations per minute. dpm = (cpm - measured background)/efficiency. Efficiency is dependent on the radioisotope used and the instrument.</rdfs:comment>
  </RadiationUnit>
  <RadiationUnit rdf:ID="Rad"/>
  <PhysicalBioSequenceType rdf:ID="ctDNA"/>
  <DataType rdf:ID="date">
    <rdfs:comment>Time stated in terms of the day, month, and year.</rdfs:comment>
  </DataType>
  <PerturbationalDesign rdf:ID="growth_condition_design">
    <rdfs:comment>A growth condition experiment design type is where some part of the growth condition is changed for the purposes of the experiment, examples of growth conditions changed are media, temperature, humidity, light, nutrients. </rdfs:comment>
  </PerturbationalDesign>
  <BioMaterialCharacteristicCategory rdf:ID="biomaterial_provider">
    <rdfs:comment>A descriptor for FactorValue where BioSource providers are compared.  </rdfs:comment>
    <rdf:type rdf:resource="#Roles"/>
  </BioMaterialCharacteristicCategory>
  <DeliveryMethod rdf:ID="ad_libitum">
    <rdfs:comment>A delivery method for compounds/drugs where the compound or drug is freely available.</rdfs:comment>
  </DeliveryMethod>
  <LaboratoryTestDatabase rdf:ID="IUPAC_Clinical_Chemistry_Guidelines">
    <has_URI rdf:resource="#http___www.iupac.org_publications_pac_2000_7205_7205olesen.html"/>
    <rdfs:comment> A resource of vocabularies for describing clinical tests, e.g. blood chemistry.</rdfs:comment>
  </LaboratoryTestDatabase>
  <PolymerType rdf:ID="RNA">
    <rdfs:comment>Ribonucleic acid.</rdfs:comment>
  </PolymerType>
  <TimeUnitOther rdf:ID="half-life"/>
  <ProtocolType rdf:ID="wash">
    <rdf:type rdf:resource="#ComplexAction"/>
    <rdfs:comment>The process of applying a solvent (e.g. water) or a solution (e.g. SSC/SDS) to a BioMaterial or an array to remove impurities or unwanted compounds.</rdfs:comment>
  </ProtocolType>
  <DesignElement rdf:ID="long_oligo">
    <rdfs:comment>An element that is an oligonucleotide of at least 50 nucleotides in length.</rdfs:comment>
  </DesignElement>
  <DerivedBioAssayType rdf:ID="ratio">
    <rdfs:comment>results of data reduction involving computation of the ratio of signal intensities obtained from hybridization of two, or more, labelled extracts to one, or more arrays   </rdfs:comment>
  </DerivedBioAssayType>
  <MaterialType rdf:ID="genomic_DNA">
    <rdfs:comment>high molecular weight DNA</rdfs:comment>
    <rdf:type rdf:resource="#PhysicalBioSequenceType"/>
  </MaterialType>
  <MaterialType rdf:ID="polyA_RNA"/>
  <Roles rdf:ID="institution">
    <rdfs:comment>A contact's affiliation, e.g. university, research institute or business.</rdfs:comment>
  </Roles>
  <ComplexAction rdf:ID="sacrifice">
    <rdfs:comment>The procedure of euthanizing an organism.</rdfs:comment>
    <rdf:type rdf:resource="#ProtocolType"/>
  </ComplexAction>
  <LightUnit rdf:ID="lumen">
    <rdfs:comment>The unit of total light output from a light source.</rdfs:comment>
  </LightUnit>
  <Allele rdf:ID="wild_type">
    <rdf:type rdf:resource="#Genotype"/>
    <rdfs:comment>The genotype or phenotype that is found in nature or in standard laboratory stocks for a given organism.  For a single locus, the allele found most frequently in natural populations, or in standard laboratory stocks for a given organism.</rdfs:comment>
  </Allele>
  <ComplexAction rdf:ID="nucleic_acid_extraction">
    <rdf:type rdf:resource="#ProtocolType"/>
    <rdfs:comment>The procedure of extracting nucleic acid from the biomaterial.</rdfs:comment>
  </ComplexAction>
  <InitialTimePoint rdf:ID="beginning_of_stage">
    <rdfs:comment>time point that indicates the start of some developmental stage</rdfs:comment>
  </InitialTimePoint>
  <BioSourceType rdf:ID="frozen_sample">
    <rdfs:comment>A biomaterial obtained frozen</rdfs:comment>
  </BioSourceType>
  <MaterialType rdf:ID="cell">
    <rdfs:comment>One or more dissociated cell(s) possibly heterogeneous, excluding single cell organisms.</rdfs:comment>
  </MaterialType>
  <TemperatureUnit rdf:ID="K">
    <rdfs:comment>Kelvin, unit of temperature</rdfs:comment>
  </TemperatureUnit>
  <BioMaterialCharacteristicCategory rdf:ID="bedding">
    <rdfs:comment></rdfs:comment>
  </BioMaterialCharacteristicCategory>
  <ComplexAction rdf:ID="infect">
    <rdf:type rdf:resource="#ProtocolType"/>
    <rdfs:comment>The organism (or organism part) has been exposed to a virus or pathogen. </rdfs:comment>
  </ComplexAction>
  <DeliveryMethod rdf:ID="intramuscular_injection">
    <rdfs:comment>Delivery method for a compound or drug where the substance is administered via an injection into the muscle.</rdfs:comment>
  </DeliveryMethod>
  <TechnologyType rdf:ID="spotted_colony_features">
    <rdfs:comment>TechnologyType of FeatureGroup where bacterial or other colonies are spotted directly.</rdfs:comment>
  </TechnologyType>
  <TheoreticalBioSequenceType rdf:ID="exon">
    <rdfs:comment>sequence which represents regions of a transcript  that are joined to another exon during splicing</rdfs:comment>
  </TheoreticalBioSequenceType>
  <FailType rdf:ID="PCR_questionable">
    <rdfs:comment>PCR with multiple bands, or smear, in gel-separated reaction products</rdfs:comment>
  </FailType>
  <TheoreticalBioSequenceType rdf:ID="exemplar_mRNA"/>
  <ChromosomalAberrationClassification rdf:ID="chromosomal_inversion">
    <rdfs:comment>Chromosome segments that have been turned through 180 degrees with the result that the gene sequence for the segment is reversed with respect to the rest of the chromosome.</rdfs:comment>
  </ChromosomalAberrationClassification>
  <DataType rdf:ID="nonpositive_integer">
    <rdfs:comment>An integer less than or equal to zero.</rdfs:comment>
  </DataType>
  <owl:Thing rdf:ID="http___www.cabri.org_CABRI_home_guidelines_catalogue_CPCel_linenamesahc.html"/>
  <VolumeUnit rdf:ID="dl">
    <rdfs:comment>deciliter, unit of volume</rdfs:comment>
  </VolumeUnit>
  <DerivedBioAssayType rdf:ID="filtered_data">
    <rdfs:comment>data from which a subset has been removed based on some criteria, e.g. data below an intensity threshhold</rdfs:comment>
  </DerivedBioAssayType>
  <HardwareType rdf:ID="wash_station"/>
  <PublicationType rdf:ID="book">
    <rdfs:comment>A publication type which has an ISBN.</rdfs:comment>
  </PublicationType>
  <ConcentrationUnit rdf:ID="pM">
    <rdfs:comment>picomolar, concentration unit</rdfs:comment>
  </ConcentrationUnit>
  <DataType rdf:ID="positive_integer">
    <rdfs:comment>An integer > 0.</rdfs:comment>
  </DataType>
  <TimeUnit rdf:ID="months">
    <rdfs:comment>Unit of time corresponding to approx. one cycle of the moon's phases.</rdfs:comment>
  </TimeUnit>
  <NodeValueType rdf:ID="Pearson_correlation"/>
  <SoftwareType rdf:ID="feature_extraction_software"/>
  <BiologicalProperty rdf:ID="unknown_experiment_design_type">
    <rdfs:comment>ExperimentDesignType of unknown type.</rdfs:comment>
    <rdf:type rdf:resource="#MethodologicalDesign"/>
    <rdf:type rdf:resource="#BioMolecularAnnotation"/>
    <rdf:type rdf:resource="#EpidemiologicalDesign"/>
    <rdf:type rdf:resource="#PerturbationalDesign"/>
  </BiologicalProperty>
  <Media rdf:ID="semisolid">
    <rdfs:comment>semisolid media type</rdfs:comment>
  </Media>
  <BioSourceType rdf:ID="feces">
    <rdfs:comment>A biosource obtained as fecal matter.</rdfs:comment>
  </BioSourceType>
  <DataType rdf:ID="list_of_nonpositive_integer"/>
  <Sex rdf:ID="mating_type_alpha">
    <rdfs:comment>Mating type of S. cerevisiae.</rdfs:comment>
  </Sex>
  <BioMaterialCharacteristicCategory rdf:ID="individual">
    <rdfs:comment>A descriptor for FactorValue where BioSources are compared. </rdfs:comment>
  </BioMaterialCharacteristicCategory>
  <ImageFormat rdf:ID="TIFF">
    <rdfs:comment>Tag Image File Format (TIFF) is a common format to describe and store raster image data  from scanners and other imaging devices. TIFFs may contain one or more channels and the data may be compressed using a lossless compression algorithm.</rdfs:comment>
  </ImageFormat>
  <PhysicalBioSequenceType rdf:ID="PCR_primer_reverse">
    <rdfs:comment>single stranded oligo used for polymerase chain reaction</rdfs:comment>
  </PhysicalBioSequenceType>
  <ReplicateDescriptionType rdf:ID="technical_replicate">
    <rdfs:comment>A replicate where the same BioSample is use e.g. the same pool of RNA used to assess technical (as opposed to biological) variation within an experiment.</rdfs:comment>
    <rdf:type rdf:resource="#QualityControlDescriptionType"/>
  </ReplicateDescriptionType>
  <RadiationUnit rdf:ID="Ci"/>
  <MethodologicalDesign rdf:ID="software_variation_design"/>
  <ConcentrationUnit rdf:ID="percent_weight_weight"/>
  <DatabaseEntryType rdf:ID="curated_nucleic_acid_sequence_feature_record">
    <rdfs:comment>A record which identifies a nucleic acid sequence feature(s) and which has been curated.</rdfs:comment>
  </DatabaseEntryType>
  <MaterialType rdf:ID="organellar_DNA">
    <rdfs:comment>DNA from organelles such as the mitochondria or chloroplast.</rdfs:comment>
  </MaterialType>
  <LabelCompound rdf:ID="Cy5">
    <rdfs:comment>flurophore used for labeling/detection purposes</rdfs:comment>
  </LabelCompound>
  <Scale rdf:ID="log_base_2">
    <rdfs:comment>The values presented are logarithm, base 2.</rdfs:comment>
  </Scale>
  <DerivedBioAssayType rdf:ID="average_difference">
    <rdfs:comment>the method used by Affymetrix to obtain mean signal intensity from a group  of related Features.  This involves calculation of the overall sum of perfect match minus  mismatch pairs divided by the number of pairs.  (MAS 4.0 version of the Affymetrix analysis software).</rdfs:comment>
  </DerivedBioAssayType>
  <DistanceUnit rdf:ID="mm">
    <rdfs:comment>millimeter, unit of distance</rdfs:comment>
  </DistanceUnit>
  <EnvironmentalFactorCategory rdf:ID="population_density">
    <rdfs:comment>The concentration range of the organism.</rdfs:comment>
  </EnvironmentalFactorCategory>
  <PhysicalBioSequenceType rdf:ID="PCR_primer">
    <rdfs:comment>single oligo used for polymerase chain reaction direction unspecified</rdfs:comment>
  </PhysicalBioSequenceType>
  <URI rdf:ID="http___www.informatics.jax.org_mgihome_GXD_AD_"/>
  <Sex rdf:ID="male">
    <rdfs:comment>individual whose sex organs contain only male gametes</rdfs:comment>
  </Sex>
  <DiseaseStateDatabase rdf:ID="ICD-9-CM">
    <has_URI rdf:resource="#ftp___ftp.cdc.gov_pub_Health_Statistics_NCHS_Publications_ICD9-CM_2002_"/>
    <rdfs:comment>Database entry from ICD 9 2001, international classification of diseases 9, clinical modification 2001.</rdfs:comment>
  </DiseaseStateDatabase>
  <FamilyRelationship rdf:ID="brother">
    <rdfs:comment> A male having the same genetic parents as another, or one genetic parent in common with another.</rdfs:comment>
  </FamilyRelationship>
  <DataType rdf:ID="nonpositive_float">
    <rdfs:comment>A float less than or equal to zero.</rdfs:comment>
  </DataType>
  <Sex rdf:ID="mating_type_a">
    <rdfs:comment>Mating type of S. cerevisiae.</rdfs:comment>
  </Sex>
  <StrainOrLineDatabase rdf:ID="TAIR">
    <rdfs:comment>The Arabadopsis Information Resource.</rdfs:comment>
    <has_URI>
      <owl:Thing rdf:ID="http___www.arabidopsis.org_servlets_Search_action_new_search_type_ecotype"/>
    </has_URI>
  </StrainOrLineDatabase>
  <DatabaseEntryType rdf:ID="phylogeny_record"/>
  <HardwareType rdf:ID="heating_block">
    <rdfs:comment>A device for controlling temperature.</rdfs:comment>
  </HardwareType>
  <DerivedBioAssayType rdf:ID="normalized_ratios">
    <rdfs:comment>ratios resulting from normalization of MeasuredBioAssayData</rdfs:comment>
  </DerivedBioAssayType>
  <PreservationType rdf:ID="seed_dormancy">
    <rdfs:comment>preservation type whereby the seed is maintained in a dormant state</rdfs:comment>
  </PreservationType>
  <FamilyRelationship rdf:ID="daughter">
    <rdfs:comment>The female offspring of the patient or individual under study.</rdfs:comment>
  </FamilyRelationship>
  <FailType rdf:ID="PCR_fail">
    <rdfs:comment>PCR where no products of any kind appear in gel-separated reaction products.</rdfs:comment>
  </FailType>
  <DefectType rdf:ID="irregular_shape">
    <rdfs:comment>The perimeter of the spotted DNA on the slide is irregular.</rdfs:comment>
  </DefectType>
  <SoftwareType rdf:ID="bioassay_data_transformation_software"/>
  <NodeValueType rdf:ID="tau_rank_correlation">
    <rdfs:comment></rdfs:comment>
  </NodeValueType>
  <ProtocolType rdf:ID="behavioral_stimulus">
    <rdf:type rdf:resource="#ComplexAction"/>
    <rdfs:comment>The organism is forced to respond to a stimulus with some behavior (e.g., avoidance, obtaining a reward, etc.) </rdfs:comment>
  </ProtocolType>
  <BiologicalProperty rdf:ID="species_design">
    <rdfs:comment>A species experiment design type assays differences between distinct species.</rdfs:comment>
  </BiologicalProperty>
  <HardwareType rdf:ID="DNA_sequencer">
    <rdfs:comment> An instrument that produces DNA sequences.</rdfs:comment>
  </HardwareType>
  <AtomicAction rdf:ID="change_temperature">
    <rdfs:comment>Change in temperature.  </rdfs:comment>
  </AtomicAction>
  <StrainOrLineDatabase rdf:ID="GRAMENE">
    <has_URI rdf:resource="#http___www.gramene.org_"/>
    <rdfs:comment>A Comparative Mapping Resource for Grains.</rdfs:comment>
  </StrainOrLineDatabase>
  <MaterialType rdf:ID="nuclear_RNA">
    <rdfs:comment>RNA obtained from the nucleus.</rdfs:comment>
  </MaterialType>
  <BioMaterialCharacteristicCategory rdf:ID="sex">
    <rdfs:comment>A descriptor for FactorValue where Sex is compared.  </rdfs:comment>
  </BioMaterialCharacteristicCategory>
  <MaterialType rdf:ID="protein">
    <rdfs:comment>Polymer of amino acids.</rdfs:comment>
    <rdf:type rdf:resource="#PolymerType"/>
  </MaterialType>
  <OrganismPartDatabase rdf:ID="eVOC">
    <has_URI>
      <owl:Thing rdf:ID="http___www.sanbi.ac.za_evoc_ontologies.html"/>
    </has_URI>
    <rdf:type rdf:resource="#DiseaseStateDatabase"/>
    <rdf:type rdf:resource="#CellTypeDatabase"/>
    <rdfs:comment>Ontology of human terms that describe the sample source of human cDNA and SAGE libraries.</rdfs:comment>
    <rdf:type rdf:resource="#DevelopmentalStageDatabase"/>
  </OrganismPartDatabase>
  <QuantityUnit rdf:ID="pmol">
    <rdfs:comment>picomoles, quantity unit</rdfs:comment>
  </QuantityUnit>
  <QuantityUnit rdf:ID="fmol"/>
  <DatabaseEntryType rdf:ID="image_record">
    <rdfs:comment>A record which describes and identifies an image, e.g. an image from the mouse atlas</rdfs:comment>
  </DatabaseEntryType>
  <BioMolecularAnnotation rdf:ID="secreted_protein_identification_design">
    <rdfs:comment>A secreted protein identification design type identifies transcripts associated with a secretory pathway during translation and is used to infer which proteins are secreted or membrane bound. </rdfs:comment>
  </BioMolecularAnnotation>
  <Roles rdf:ID="data_coder">
    <rdfs:comment>Person who codes data.</rdfs:comment>
  </Roles>
  <DevelopmentalStageDatabase rdf:ID="MAD_stage">
    <rdf:type rdf:resource="#TargetedCellTypeDatabase"/>
    <rdfs:comment>database entry from mouse anatomical dictionary for developmental stage term</rdfs:comment>
    <rdf:type rdf:resource="#OrganismPartDatabase"/>
    <has_URI rdf:resource="#http___www.informatics.jax.org_mgihome_GXD_AD_"/>
  </DevelopmentalStageDatabase>
  <HardwareType rdf:ID="vacuum_dryer"/>
  <HardwareType rdf:ID="arrayer">
    <rdfs:comment>An instrument capable of manufacturing arrays by spotting material.</rdfs:comment>
  </HardwareType>
  <EnvironmentalHistory rdf:ID="environmental_history_design">
    <rdfs:comment>An environmental history design type is where some aspect of the organism's environmental history is studied, such as exposure to teratogen, radiation, climate etc.</rdfs:comment>
  </EnvironmentalHistory>
  <MethodologicalDesign rdf:ID="reference_design">
    <rdfs:comment>A reference experiment design type is where all samples are compared to a common reference. </rdfs:comment>
  </MethodologicalDesign>
  <AtomicAction rdf:ID="mix_by_inversion">
    <rdfs:comment>Mix through the process of inverting.</rdfs:comment>
  </AtomicAction>
  <DerivedBioAssayType rdf:ID="mean_and_confidence_indicators">
    <rdfs:comment>the mean and associated confidence values resulting from combining the data from 2 or more sets of BioAssayData.  Confidence indicators include, but are not limited to:confidence interval, standard deviation, coefficient of variation, and p-value.</rdfs:comment>
  </DerivedBioAssayType>
  <FamilyRelationship rdf:ID="granddaughter">
    <rdfs:comment>A daughter of one's son or daughter.</rdfs:comment>
  </FamilyRelationship>
  <OrganismStatus rdf:ID="premortem">
    <rdfs:comment>sample which has been removed prior to the death of an organism</rdfs:comment>
  </OrganismStatus>
  <NormalizationDescriptionType rdf:ID="low_intensity_filter">
    <rdfs:comment>A transformation method that involves removal of Features with low intensities in one or both  channels from the data set.  The threshold for exclusion is usually based on some  estimation of local background intensity.</rdfs:comment>
  </NormalizationDescriptionType>
  <URI rdf:ID="http___portal.bioengineering.elyt.ods.org_ontology_"/>
  <QuantityUnit rdf:ID="molecules">
    <rdfs:comment>number of molecules, quantity unit</rdfs:comment>
  </QuantityUnit>
  <ControlType rdf:ID="control_label"/>
  <TheoreticalBioSequenceType rdf:ID="intron"/>
  <InitialTimePoint rdf:ID="birth">
    <rdfs:comment>the action of emergence and separation of offspring from the mother.</rdfs:comment>
  </InitialTimePoint>
  <BioSourceType rdf:ID="biopsy">
    <rdfs:comment>A biomaterial, usually tissue, cells, or fluid from a living organism</rdfs:comment>
  </BioSourceType>
  <AtomicAction rdf:ID="remove">
    <rdfs:comment>The procedure of extracting/taking out a part of a reaction/contents of a container.</rdfs:comment>
  </AtomicAction>
  <HardwareType rdf:ID="homogenizer">
    <rdfs:comment>An instrument which fragments tissues or other biomaterials.</rdfs:comment>
  </HardwareType>
  <ConcentrationUnit rdf:ID="percent_vol_vol"/>
  <Media rdf:ID="liquid">
    <rdfs:comment>media type, usually some sort of broth</rdfs:comment>
  </Media>
  <HardwareType rdf:ID="spectrophotometer">
    <rdfs:comment>Hardware for measuring light at different wavelengths.</rdfs:comment>
  </HardwareType>
  <Sex rdf:ID="F"/>
  <Ploidy rdf:ID="haploid"/>
  <NormalizationDescriptionType rdf:ID="lowess_normalization"/>
  <DiseaseStateDatabase rdf:ID="TDMS">
    <rdfs:comment>Toxicology Data Management System, a database resource for systems, organs, pathology, etc.</rdfs:comment>
    <has_URI rdf:resource="#http___hazel.niehs.nih.gov_user_spt_pct_terms.htm"/>
    <rdf:type rdf:resource="#HistologyDatabase"/>
  </DiseaseStateDatabase>
  <VolumeUnit rdf:ID="fl">
    <rdfs:comment>femtoliter, unit of volume</rdfs:comment>
  </VolumeUnit>
  <BioMaterialCharacteristicCategory rdf:ID="individual_genetic_characteristic">
    <rdfs:comment>A descriptor for FactorValue where IndividualGeneticCharacteristic is compared.  </rdfs:comment>
  </BioMaterialCharacteristicCategory>
  <FamilyRelationship rdf:ID="sister"/>
  <SequenceOntologyDatabase rdf:ID="SequenceOntology">
    <rdfs:comment></rdfs:comment>
    <has_URI>
      <owl:Thing rdf:ID="http___song.sourceforge.net_"/>
    </has_URI>
  </SequenceOntologyDatabase>
  <RadiationUnit rdf:ID="R"/>
  <PerturbationalDesign rdf:ID="injury_design">
    <rdfs:comment>An injury experiment design type is where the response of an organism(s) to injury or damage is studied.</rdfs:comment>
  </PerturbationalDesign>
  <DataType rdf:ID="negative_float">
    <rdfs:comment>A float that is &lt; 0.</rdfs:comment>
  </DataType>
  <MethodologicalDesign rdf:ID="normalization_testing_design">
    <rdfs:comment>A normalization testing experiment design tests different normalization procedures.</rdfs:comment>
  </MethodologicalDesign>
  <LaboratoryTestDatabase rdf:ID="LOINC">
    <has_URI rdf:resource="#http___www.loinc.org_download"/>
    <rdfs:comment>Database resource for universal identifiers for laboratory and other clinical observations</rdfs:comment>
  </LaboratoryTestDatabase>
  <MassUnit rdf:ID="fg">
    <rdfs:comment>femtogram, unit of mass</rdfs:comment>
  </MassUnit>
  <MethodologicalDesign rdf:ID="hardware_variation_design">
    <rdfs:comment>A hardware variation experiment design type compares different types of hardware for performance, reproducibility, accuracy and precision.</rdfs:comment>
  </MethodologicalDesign>
  <Scale rdf:ID="log_base_10">
    <rdfs:comment>The values presented are logarithm, base 10.</rdfs:comment>
  </Scale>
  <LabelCompound rdf:ID="alexa_568"/>
  <DiseaseStateDatabase rdf:ID="WebRENI">
    <has_URI>
      <URI rdf:ID="http___www.item.fraunhofer.de_reni_index.htm"/>
    </has_URI>
    <rdfs:comment>database entry from WebReni A resource for rat and mouse unified nomenclature describing lesions</rdfs:comment>
  </DiseaseStateDatabase>
  <LabelCompound rdf:ID="Cy3">
    <rdfs:comment>flurophore used for labeling/detection purposes</rdfs:comment>
  </LabelCompound>
  <ConcentrationUnit rdf:ID="uM">
    <rdfs:comment>micromolar, concentration unit</rdfs:comment>
  </ConcentrationUnit>
  <SubstrateType rdf:ID="glass">
    <rdfs:comment>The array is made on a glass slide.</rdfs:comment>
  </SubstrateType>
  <ConcentrationUnitOther rdf:ID="mOsm_kg_H2O"/>
  <QuantityUnit rdf:ID="nmol">
    <rdfs:comment>nanomoles, quantity unit</rdfs:comment>
  </QuantityUnit>
  <ConcentrationUnitOther rdf:ID="cells_ml"/>
  <InitialTimePoint rdf:ID="hatching">
    <rdfs:comment>The point at which an organism emerges from an egg.</rdfs:comment>
  </InitialTimePoint>
  <SurfaceType rdf:ID="aminosilane">
    <rdfs:comment>A type of surface coating.</rdfs:comment>
  </SurfaceType>
  <ImageFormat rdf:ID="JPEG">
    <rdfs:comment>Joint Photographic Experts Group format, a common image data format containing grayscale or RGB data compressed with little to high data loss.</rdfs:comment>
  </ImageFormat>
  <DesignElement rdf:ID="short_oligo">
    <rdfs:comment>An element that is an oligonucleotide of less than 50 nucleotides in length (usually 20 to 25 nt as in Affymetrix probes).</rdfs:comment>
  </DesignElement>
  <DerivedBioAssayType rdf:ID="dye_swap_replicate_reduction">
    <rdfs:comment>results of data reduction involving computation of a representative value, e.g. by averaging, for identical Features, Reporters or CompositeSequences from 2 hybridizations utilizing dye-swapped LabeledExtracts.</rdfs:comment>
  </DerivedBioAssayType>
  <Scale rdf:ID="linear_scale"/>
  <QuantityUnit rdf:ID="umol">
    <rdfs:comment>micromoles, quantity unit</rdfs:comment>
  </QuantityUnit>
  <Roles rdf:ID="data_analyst">
    <rdfs:comment>A contact who performs data analysis, e.g. statistician.</rdfs:comment>
  </Roles>
  <VolumeUnit rdf:ID="nl">
    <rdfs:comment>nanoliter unit of volume</rdfs:comment>
  </VolumeUnit>
  <DesignElementGroupType rdf:ID="experimental_design_element_group_type">
    <rdfs:comment>A grouping of DesignElements, Features/Reporters/Composite Sequences which are expected to detect a signal in the biomaterial.</rdfs:comment>
  </DesignElementGroupType>
  <DataType rdf:ID="list_of_nonnegative_integer"/>
  <DatabaseEntryType rdf:ID="nucleic_acid_primary_sequence_record">
    <rdfs:comment>A record which describes and identifies a primary sequence record e.g. DDBJ/EMBL/Genbank</rdfs:comment>
  </DatabaseEntryType>
  <ProtocolType rdf:ID="grow">
    <rdfs:comment>A ComplexAction or ProtocolType describing growth of an organism or cell culture.</rdfs:comment>
    <rdf:type rdf:resource="#ComplexAction"/>
  </ProtocolType>
  <TheoreticalBioSequenceType rdf:ID="operon"/>
  <SoftwareType rdf:ID="liquid_handler_software">
    <rdfs:comment>Software used to control automated liquid handler.</rdfs:comment>
  </SoftwareType>
  <FamilyRelationship rdf:ID="father">
    <rdfs:comment>A male parent.</rdfs:comment>
  </FamilyRelationship>
  <BiologicalProperty rdf:ID="cell_type_comparison_design">
    <rdfs:comment>A cell type comparison design experiment design type compares cells of different type for example different cell lines.</rdfs:comment>
  </BiologicalProperty>
  <Roles rdf:ID="hardware_manufacturer">
    <rdfs:comment>Person or organization that manufactured the hardware.</rdfs:comment>
  </Roles>
  <DatabaseEntryType rdf:ID="computed_protein_structure_record">
    <rdfs:comment>a record which describes and identifies a protein structure e.g. PDB</rdfs:comment>
  </DatabaseEntryType>
  <Roles rdf:ID="investigator">
    <rdfs:comment>Person who contributed to the study.</rdfs:comment>
  </Roles>
  <ComplexAction rdf:ID="irradiate">
    <rdf:type rdf:resource="#ProtocolType"/>
    <rdfs:comment>treatment of a biomaterial with radiation e.g. electromagnetic radiation</rdfs:comment>
  </ComplexAction>
  <GeneticModification rdf:ID="gene_knock_out">
    <rdfs:comment>The modification of an organism that renders a gene non-functional e.g. due to the removal of all, or part of, the gene using recombinant methods.</rdfs:comment>
  </GeneticModification>
  <BioMolecularAnnotation rdf:ID="operon_identification_design">
    <rdfs:comment>An operon identification experiment type is designed to identify locations and members of operons in a genome.</rdfs:comment>
  </BioMolecularAnnotation>
  <StrainOrLineDatabase rdf:ID="NCBI_taxonomy">
    <has_URI>
      <owl:Thing rdf:ID="http___www.ncbi.nlm.nih.gov_Taxonomy_taxonomyhome.html_"/>
    </has_URI>
    <rdfs:comment>identifier for  a taxon provided by the NCBI taxonomy database</rdfs:comment>
    <rdf:type rdf:resource="#OrganismDatabase"/>
  </StrainOrLineDatabase>
  <DatabaseEntryType rdf:ID="computed_nucleic_acid_sequence_feature_record">
    <rdfs:comment>A record which identifies and describes a nucleic sequence feature which has been computationally determined or predeicted E.g. and Ensembl record</rdfs:comment>
  </DatabaseEntryType>
  <PerturbationalDesign rdf:ID="non-targeted_transgenic_variation_design">
    <rdfs:comment>The modification of an organism due to the presence of DNA from another individual, e.g. of a different strain, species or breed. These do not include targeted transgenics such as knock-ins and knock-outs.</rdfs:comment>
  </PerturbationalDesign>
  <Roles rdf:ID="consortium_member">
    <rdfs:comment>A member of a consortium of institutions.</rdfs:comment>
  </Roles>
  <ComplexAction rdf:ID="pool">
    <rdf:type rdf:resource="#ProtocolType"/>
  </ComplexAction>
  <DataType rdf:ID="list_of_boolean">
    <rdfs:comment>An ordered, finite set of booleans.</rdfs:comment>
  </DataType>
  <DefectType rdf:ID="diameter_aberration">
    <rdfs:comment>The diameter of the Feature is much smaller or much larger than expected based on the spotting pin diameter.</rdfs:comment>
  </DefectType>
  <DatabaseEntryType rdf:ID="pathway_record">
    <rdfs:comment>a record which identifies and describes biological pathways, e.g. a KEGG record</rdfs:comment>
  </DatabaseEntryType>
  <InitialTimePoint rdf:ID="coitus">
    <rdfs:comment>sexual intercourse or copulation</rdfs:comment>
  </InitialTimePoint>
  <NodeValueType rdf:ID="jackknife_Pearson_correlation"/>
  <DatabaseEntryType rdf:ID="primary_protein_structure_record"/>
  <ConcentrationUnitOther rdf:ID="pfu_ml"/>
  <ImageFormat rdf:ID="Affymetrix_DAT"/>
  <BioMaterialCharacteristicCategory rdf:ID="disease_state">
    <rdfs:comment>A descriptor for FactorValue where DiseaseState is compared.  </rdfs:comment>
  </BioMaterialCharacteristicCategory>
  <DerivedBioAssayType rdf:ID="collapsed_spot_replicate">
    <rdfs:comment>results of data reduction involving computation of a representative value, e.g. by averaging, for a group of replicated Features, Reporters or CompositeSequences from a single hybridization.</rdfs:comment>
  </DerivedBioAssayType>
  <BioMaterialCharacteristicCategory rdf:ID="disease_staging">
    <rdfs:comment>The stage or progression of a disease in an organism. Includes pathological staging of cancers and other disease progression. </rdfs:comment>
  </BioMaterialCharacteristicCategory>
  <LabelCompound rdf:ID="biotin">
    <rdfs:comment>a compound used for labeling/detection purposes</rdfs:comment>
  </LabelCompound>
  <PhysicalBioSequenceType rdf:ID="YAC">
    <rdfs:comment>sequence from yeast artificial chromosome</rdfs:comment>
  </PhysicalBioSequenceType>
  <ChromosomalAberrationClassification rdf:ID="robertsonian_translocation">
    <rdfs:comment>Translocation in which the centromeres of two acrocentric chromosomes appear to have fused, forming an abnormal chromosome consisting of the long arms of two different chromosomes with loss of the short arms.</rdfs:comment>
  </ChromosomalAberrationClassification>
  <MassUnit rdf:ID="ng"/>
  <TimeUnit rdf:ID="us">
    <rdfs:comment>microsecond, unit of time</rdfs:comment>
  </TimeUnit>
  <DatabaseEntryType rdf:ID="computed_amino_acid_sequence_feature_record">
    <rdfs:comment>a record which describes and identifies an amino acid feature which is computationally derived  e.g. PFAM</rdfs:comment>
  </DatabaseEntryType>
  <LabelCompound rdf:ID="alexa_680"/>
  <ProtocolType rdf:ID="compound_based_treatment">
    <rdfs:comment>The treatment is effected by a defined chemical, biological or compound.   The compound may be a drug, solvent, chemical, etc., with a property that can be measured such as concentration.</rdfs:comment>
    <rdf:type rdf:resource="#ComplexAction"/>
  </ProtocolType>
  <TheoreticalBioSequenceType rdf:ID="mRNA">
    <rdfs:comment>sequence of a processed transcript capable of directing protein synthesis</rdfs:comment>
  </TheoreticalBioSequenceType>
  <PerturbationalDesign rdf:ID="pathogenicity_design">
    <rdfs:comment>A pathogenicity experiment design type is where an infective agent such as a bacterium, virus, protozoan, fungus etc. infects a host organism(s) and the infective agent is assayed.</rdfs:comment>
  </PerturbationalDesign>
  <DataType rdf:ID="list_of_float">
    <rdfs:comment>An ordered, finite set of floats.</rdfs:comment>
  </DataType>
  <TemperatureUnit rdf:ID="degrees_F">
    <rdfs:comment>degrees Fahrenheit, unit of temperature</rdfs:comment>
  </TemperatureUnit>
  <LightUnit rdf:ID="candelas_per_square_meter">
    <rdfs:comment>Unit of brightness or luminance.</rdfs:comment>
  </LightUnit>
  <DataType rdf:ID="list_of_negative_float">
    <rdfs:comment>An ordered, finite set of negative floats.</rdfs:comment>
  </DataType>
  <ConcentrationUnitOther rdf:ID="pH">
    <rdfs:comment>potential of hydrogen</rdfs:comment>
  </ConcentrationUnitOther>
  <AtomicAction rdf:ID="add">
    <rdfs:comment>The procedure of placing one physical object in the same container/physical space as another.</rdfs:comment>
  </AtomicAction>
  <BioMaterialCharacteristicCategory rdf:ID="clinical_information">
    <rdfs:comment>A descriptor for FactorValue where ClinicalInformation is compared.  </rdfs:comment>
  </BioMaterialCharacteristicCategory>
  <FeatureShape rdf:ID="square_feature">
    <rdfs:comment>The shape of the feature on the array is square.</rdfs:comment>
  </FeatureShape>
  <ProtocolType rdf:ID="array_manufacturing">
    <rdfs:comment>The process of manufacturing the array.</rdfs:comment>
  </ProtocolType>
  <StrandType rdf:ID="forward"/>
  <Media rdf:ID="soil">
    <rdfs:comment>soil, growth media for plants and other soil living organisms</rdfs:comment>
  </Media>
  <BiologicalProperty rdf:ID="cell_cycle_design">
    <rdfs:comment>A cell cycle design experiment design type is one that assays events that occurs in relation to the cell cycle, which is the period between the formation of a cell, by division of its mother cell and the time when the cell itself divides to form two daughter cells.</rdfs:comment>
  </BiologicalProperty>
  <NormalizationDescriptionType rdf:ID="linear_regression_normalization">
    <rdfs:comment>A method of re-scaling intensity data from one channel relative to another based on  regression of the intensities in one channel on those of the other.  The slope of the  regression line is used to re-scale the intensities in one channel for each Feature.  This  single parameter method assumes that there is a linear relationship between the intensities  in one channel relative to the other.</rdfs:comment>
  </NormalizationDescriptionType>
  <HardwareType rdf:ID="array_scanner"/>
  <MassUnit rdf:ID="g">
    <rdfs:comment>gram, unit of mass</rdfs:comment>
  </MassUnit>
  <DataType rdf:ID="boolean"/>
  <TheoreticalBioSequenceType rdf:ID="transcript">
    <rdfs:comment>sequence that represents the product of an RNA polymerase engaged in transcription </rdfs:comment>
  </TheoreticalBioSequenceType>
  <StrandType rdf:ID="double_stranded">
    <rdfs:comment>a nucleic acid consiting of two polynucleotide chains having antiparallel orientation and being bound together by hydrogen bonding between the chains.  This would apply to DNA and some RNA genomes, but not to rRNA or tRNA, etc.</rdfs:comment>
  </StrandType>
  <DatabaseEntryType rdf:ID="amino_acid_primary_sequence_record">
    <rdfs:comment>A record which describes and identifies an amino acid sequence which is encoded by a CDS from a primary_nucleic_acid_sequence_record</rdfs:comment>
  </DatabaseEntryType>
  <ControlType rdf:ID="control_empty">
    <rdfs:comment>A Reporter where no material or  buffer was deposited on the array</rdfs:comment>
  </ControlType>
  <FamilyRelationship rdf:ID="grandson">
    <rdfs:comment>A son of one's son or daughter.</rdfs:comment>
  </FamilyRelationship>
  <EpidemiologicalDesign rdf:ID="clinical_history_design">
    <rdfs:comment>A clinical history design type is where the organisms clinical history of diagnosis,  treatments, e.g. vaccinations, surgery etc. is studied.</rdfs:comment>
  </EpidemiologicalDesign>
  <PhysicalBioSequenceType rdf:ID="antibody">
    <rdfs:comment>glycoprotein of the immunoglobulin family that can combine specifically non-covalently, reversibly with a corresponding antigen </rdfs:comment>
  </PhysicalBioSequenceType>
  <VolumeUnit rdf:ID="cc">
    <rdfs:comment>a cubic centimeter, volume unit</rdfs:comment>
  </VolumeUnit>
  <Ploidy rdf:ID="diploid">
    <rdfs:comment>Describes a cell, nucleus or an organism with two copies of each chromosome.</rdfs:comment>
  </Ploidy>
  <ComplexAction rdf:ID="split">
    <rdf:type rdf:resource="#ProtocolType"/>
  </ComplexAction>
  <DistanceUnit rdf:ID="cm">
    <rdfs:comment>centimeter, a unit of distance</rdfs:comment>
  </DistanceUnit>
  <TheoreticalBioSequenceType rdf:ID="predicted_gene">
    <rdfs:comment>gene sequence which has been computationally predicted</rdfs:comment>
  </TheoreticalBioSequenceType>
  <LabelCompound rdf:ID="_32P"/>
  <TimeUnit rdf:ID="weeks">
    <rdfs:comment>7 days, unit of time</rdfs:comment>
  </TimeUnit>
  <BioMaterialCharacteristicCategory rdf:ID="tumor_grading">
    <rdfs:comment>A descriptor used in cancer biology to describe abnormalities of tumor cells.</rdfs:comment>
  </BioMaterialCharacteristicCategory>
  <DevelopmentalStageDatabase rdf:ID="HUMAT">
    <rdfs:comment>Ontology of human developmental anatomy for Carnegie stages 1-20. </rdfs:comment>
    <has_URI>
      <owl:Thing rdf:ID="http___obo.sourceforge.net_list.shtml"/>
    </has_URI>
  </DevelopmentalStageDatabase>
  <MassUnit rdf:ID="kg">
    <rdfs:comment>kilogram, 1000 grams, unit of mass</rdfs:comment>
  </MassUnit>
  <SoftwareType rdf:ID="operating_system">
    <rdfs:comment>Software upon which other software runs.</rdfs:comment>
  </SoftwareType>
  <TheoreticalBioSequenceType rdf:ID="tRNA_gene"/>
  <ConcentrationUnitOther rdf:ID="kat_l"/>
  <ComplexAction rdf:ID="transfect">
    <rdfs:comment>The process of bringing about genetic alteration of any cell or organism by a variety of means including recombinant DNA technology, viruses, chemical mutagens, and X-rays.</rdfs:comment>
    <rdf:type rdf:resource="#ProtocolType"/>
  </ComplexAction>
  <ConcentrationUnit rdf:ID="percent_weight_vol"/>
  <DatabaseEntryType rdf:ID="clinical_record">
    <rdfs:comment>ecord which describes and identifies clinical information about an organism</rdfs:comment>
  </DatabaseEntryType>
  <DiseaseStateDatabase rdf:ID="GALEN">
    <has_URI rdf:resource="#http___www.opengalen.org_open_crm_crm-anatomy.html"/>
    <rdfs:comment>database entry from GALEN common reference model, a resource for medical coding and terminology</rdfs:comment>
  </DiseaseStateDatabase>
  <HardwareType rdf:ID="thermal_cycler"/>
  <TheoreticalBioSequenceType rdf:ID="gene_fragment">
    <rdfs:comment>sequence of part of a gene, which is missing one or both ends</rdfs:comment>
  </TheoreticalBioSequenceType>
  <MethodologicalDesign rdf:ID="dye_swap_design"/>
  <BioMaterialCharacteristicCategory rdf:ID="strain_or_line">
    <rdfs:comment>A descriptor of FactorValue where comparisons of strains or lines are made. </rdfs:comment>
  </BioMaterialCharacteristicCategory>
  <DataType rdf:ID="float"/>
  <DistanceUnit rdf:ID="nm"/>
  <BioMaterialCharacteristicCategory rdf:ID="physical_characteristics">
    <rdfs:comment>A descriptor for FactorValue where PhysicalCharacteristics are compared.  </rdfs:comment>
  </BioMaterialCharacteristicCategory>
  <DataType rdf:ID="negative_integer">
    <rdfs:comment>An integer &lt; 0.</rdfs:comment>
  </DataType>
  <EnvironmentalFactorCategory rdf:ID="nutrients">
    <rdfs:comment>The food provided to the organism (e.g., chow, fertilizer, DEMM 10%FBS, etc.).</rdfs:comment>
  </EnvironmentalFactorCategory>
  <HardwareType rdf:ID="liquid_handler">
    <rdfs:comment>Hardware for automated liquid transfer and handling.</rdfs:comment>
  </HardwareType>
  <BioMaterialCharacteristicCategory rdf:ID="organism_status">
    <rdfs:comment>The stage premortem or postmortem at which the sample was processed for extraction of biomaterials. </rdfs:comment>
  </BioMaterialCharacteristicCategory>
  <ProtocolType rdf:ID="fractionate">
    <rdfs:comment>The action of separating a BioMaterial into one or more fractions e.g. differential centrifugation or FACS when used for cell sorting (see purify).</rdfs:comment>
    <rdf:type rdf:resource="#ComplexAction"/>
  </ProtocolType>
  <ProtocolType rdf:ID="bioassay_data_transformation">
    <rdfs:comment>A computational procedure used to process or transform one BioAssayDataCube into another.</rdfs:comment>
  </ProtocolType>
  <InitialTimePoint rdf:ID="eclosion">
    <rdfs:comment>Emergence of an adult insect from its pupa or cocoon.</rdfs:comment>
  </InitialTimePoint>
  <TimeUnit rdf:ID="minutes">
    <rdfs:comment>60 seconds, unit of time</rdfs:comment>
  </TimeUnit>
  <BioMaterialCharacteristicCategory rdf:ID="developmental_stage">
    <rdfs:comment>A descriptor for FactorValue where DevelopmentalStage is compared.  </rdfs:comment>
  </BioMaterialCharacteristicCategory>
  <AtomicAction rdf:ID="spin"/>
  <AtomicAction rdf:ID="mix_by_vortex">
    <rdfs:comment>Mix through the use of a vortexer.</rdfs:comment>
  </AtomicAction>
  <Roles rdf:ID="biosequence_provider">
    <rdfs:comment>Provider of biosequences (clones, oligos etc) for deposition on the array.</rdfs:comment>
  </Roles>
  <Roles rdf:ID="submitter">
    <rdfs:comment>Person who is the primary contact for data submitted to a database.</rdfs:comment>
  </Roles>
  <DataType rdf:ID="list_of_positive_float"/>
  <AtomicAction rdf:ID="concentrate">
    <rdfs:comment>Increasing the concentration of solutes in a solution or suspension.  </rdfs:comment>
  </AtomicAction>
  <DataType rdf:ID="list_of_positive_integer">
    <rdfs:comment>An ordered, finite set of positive integers.</rdfs:comment>
  </DataType>
  <ComplexAction rdf:ID="hybridization">
    <rdf:type rdf:resource="#ProtocolType"/>
    <rdfs:comment>The process of incubating one or more labeled extracts with an array.</rdfs:comment>
  </ComplexAction>
  <MethodologicalDesign rdf:ID="replicate_design">
    <rdfs:comment>A replicate experimental design type is where a series of replicates are performed to evaluate reproducibility or as a pilot study to determine the appropriate number of replicates for a subsequent experiments.</rdfs:comment>
  </MethodologicalDesign>
  <CellTypeDatabase rdf:ID="CBIL_CV">
    <has_URI>
      <URI rdf:ID="http___www.cbil.upenn.edu_anatomy.php3"/>
    </has_URI>
    <rdf:type rdf:resource="#TargetedCellTypeDatabase"/>
    <rdf:type rdf:resource="#OrganismPartDatabase"/>
    <rdfs:comment>a controlled vocabulary provided by CBIL</rdfs:comment>
  </CellTypeDatabase>
  <MethodologicalDesign rdf:ID="time_series_design">
    <rdfs:comment>Groups of assays that are related as part of a time series.</rdfs:comment>
  </MethodologicalDesign>
  <PhysicalBioSequenceType rdf:ID="cosmid">
    <rdfs:comment>sequence from cosmid, a hybrid cloning vector containing cos sites, usually of ~40kB size</rdfs:comment>
  </PhysicalBioSequenceType>
  <MaterialType rdf:ID="molecular_mixture">
    <rdfs:comment>an unspecified collection of heterogeneous molecules, e.g. lipids, carbohydrate , nucleic acids and proteins</rdfs:comment>
  </MaterialType>
  <Roles rdf:ID="array_manufacturer">
    <rdfs:comment>Person or organization that manufactured the array.</rdfs:comment>
  </Roles>
  <BiologicalProperty rdf:ID="development_or_differentiation_design">
    <rdfs:comment>A development or differentiation experiment design type assays events associated with development or differentiation or moving through a life cycle. Development applies to organism(s) acquiring a mature state, and differentiation applies to cells acquiring specialized functions.</rdfs:comment>
  </BiologicalProperty>
  <Roles rdf:ID="curator">
    <rdfs:comment>Person who curates data.</rdfs:comment>
  </Roles>
  <Sex rdf:ID="F-"/>
  <DataType rdf:ID="list_of_nonnegative_float"/>
  <DerivedBioAssayType rdf:ID="log_ratio"/>
  <FeatureShape rdf:ID="rectangular_feature">
    <rdfs:comment>The shape of the feature on the array is rectangular.</rdfs:comment>
  </FeatureShape>
  <DataType rdf:ID="list_of_negative_integer">
    <rdfs:comment>An ordered, finite set of negative integers.</rdfs:comment>
  </DataType>
  <ConcentrationUnit rdf:ID="fM">
    <rdfs:comment>femtomolar, concentration unit</rdfs:comment>
  </ConcentrationUnit>
  <EpidemiologicalDesign rdf:ID="disease_state_design">
    <rdf:type rdf:resource="#PerturbationalDesign"/>
    <rdfs:comment>A disease state experiment design type is where the state of some disease such as infection, pathology, syndrome, etc is studied. </rdfs:comment>
  </EpidemiologicalDesign>
  <CellLineDatabase rdf:ID="CABRI_linenamesahc">
    <has_URI rdf:resource="#http___www.cabri.org_CABRI_home_guidelines_catalogue_CPCel_linenamesahc.html"/>
    <rdfs:comment>Database entry from CABRI, a database listing sources such as cell lines, bacteria, plasmids etc.</rdfs:comment>
  </CellLineDatabase>
  <MaterialType rdf:ID="cell_lysate">
    <rdfs:comment>cell lysate, a collection of cells whose membranes have been disrupted</rdfs:comment>
  </MaterialType>
  <BioMolecularAnnotation rdf:ID="co-expression_design"/>
  <VolumeUnit rdf:ID="pl">
    <rdfs:comment>picoliter, volume unit</rdfs:comment>
  </VolumeUnit>
  <DefectType rdf:ID="not_uniform">
    <rdfs:comment>The source DNA for a Feature was not uniformly deposited.</rdfs:comment>
  </DefectType>
  <NormalizationDescriptionType rdf:ID="flip-dye_consistency">
    <rdfs:comment>A method of checking the consistency of expression levels between a pair of features from  flip-dye hybridizations by studying the distribution of the logarithm of ratios of intensity  ratios from the two spots.</rdfs:comment>
  </NormalizationDescriptionType>
  <RadiationUnit rdf:ID="Rem"/>
  <PhysicalBioSequenceType rdf:ID="clone">
    <rdfs:comment>Sequence from some nucleic acid copy and the associated vector</rdfs:comment>
  </PhysicalBioSequenceType>
  <PhysicalBioSequenceType rdf:ID="PAC"/>
  <FiducialType rdf:ID="laser_ablation_mark"/>
  <TheoreticalBioSequenceType rdf:ID="promoter">
    <rdfs:comment>genomic sequence 5' to a gene where the transcription initiation complex forms.</rdfs:comment>
  </TheoreticalBioSequenceType>
  <MethodologicalDesign rdf:ID="loop_design"/>
  <DatabaseEntryType rdf:ID="curated_gene_record"/>
  <DesignElement rdf:ID="PCR">
    <rdfs:comment>Polymerase chain reaction.  An element generated using this procedure.</rdfs:comment>
  </DesignElement>
  <AtomicAction rdf:ID="change_humidity">
    <rdfs:comment>The action of changing the relative humidity, e.g. from 1% to 10%.</rdfs:comment>
  </AtomicAction>
  <Ploidy rdf:ID="aneuploid">
    <rdfs:comment>Describes a cell, nucleus or an organism whose chromosome number is not an exact multiple of the haploid number (n).</rdfs:comment>
  </Ploidy>
  <TimeUnit rdf:ID="ms">
    <rdfs:comment>millisecond, time unit</rdfs:comment>
  </TimeUnit>
  <owl:Thing rdf:ID="http___tumor.informatics.jax.org"/>
  <ChromosomalAberrationClassification rdf:ID="chromosomal_deletion">
    <rdfs:comment>The loss of a segment of the genetic material from a chromosome.</rdfs:comment>
  </ChromosomalAberrationClassification>
  <ConcentrationUnitOther rdf:ID="cfu_ml"/>
  <DatabaseEntryType rdf:ID="bibliographic_record"/>
  <FamilyRelationship rdf:ID="grandmother">
    <rdfs:comment>The mother of one's father or mother.</rdfs:comment>
  </FamilyRelationship>
  <VolumeUnit rdf:ID="ul">
    <rdfs:comment>microliter, unit of volume</rdfs:comment>
  </VolumeUnit>
  <ControlType rdf:ID="control_unknown_type">
    <rdfs:comment>A Reporter indicated as being a control of unknown type. </rdfs:comment>
  </ControlType>
  <ComplexAction rdf:ID="genetic_modification">
    <rdfs:comment>An action whereby an organism(s) has had genetic material removed, added, or rearranged.</rdfs:comment>
    <rdf:type rdf:resource="#ProtocolType"/>
  </ComplexAction>
  <ProtocolType rdf:ID="feature_extraction"/>
  <ProtocolType rdf:ID="image_acquisition">
    <rdfs:comment>The process of generating an image from the array.</rdfs:comment>
    <rdf:type rdf:resource="#ComplexAction"/>
  </ProtocolType>
  <HardwareType rdf:ID="oligo_synthesizer">
    <rdfs:comment>Hardware for synthesizing oligos.</rdfs:comment>
  </HardwareType>
  <NodeValueType rdf:ID="Euclidean_distance"/>
  <BioMolecularAnnotation rdf:ID="binding_site_identification_design"/>
  <MethodologicalDesign rdf:ID="optimization_design">
    <rdfs:comment>An optimization experiment design type is where different protocols or  protocol parameters are compared.</rdfs:comment>
  </MethodologicalDesign>
  <Media rdf:ID="agar">
    <rdfs:comment>A type of solid media commonly used for growing organisms</rdfs:comment>
  </Media>
  <ConcentrationUnit rdf:ID="M"/>
  <QualityControlDescriptionType rdf:ID="spike_quality_control">
    <rdfs:comment>An experiment in which spikes were introduced into some or all of the hybridizations for quality control or data transformation purposes.</rdfs:comment>
  </QualityControlDescriptionType>
  <BioMolecularAnnotation rdf:ID="translational_bias_design">
    <rdfs:comment>A translational bias is an experiment design which characterizes the association of transcripts and translation machinery.</rdfs:comment>
  </BioMolecularAnnotation>
  <ControlType rdf:ID="control_biosequence">
    <rdfs:comment>A Reporter associated with a BioSequence that has a context dependent predicted signal. e.g. a yeast reporter on a human array is a control_biosequence expected to be of low signal if no spikes are used. If spikes are used, the signal is expected to be high.</rdfs:comment>
  </ControlType>
  <DerivedBioAssayType rdf:ID="signal_log_ratio"/>
  <DiseaseStateDatabase rdf:ID="MTB_Database">
    <has_URI rdf:resource="#http___tumor.informatics.jax.org"/>
    <rdfs:comment>Database entry from the mouse tumor biology database, a resource for nomenclature of mouse tumors.</rdfs:comment>
  </DiseaseStateDatabase>
  <DerivedBioAssayType rdf:ID="mean_and_p_values">
    <rdfs:comment>the mean and associated p-values resulting from computationally combining 2 or more sets of BioAssayData</rdfs:comment>
  </DerivedBioAssayType>
  <AtomicAction rdf:ID="mix_general">
    <rdfs:comment>The procedure of agitating 2 or more materials in order to combine them. The materials may be of any state solid/liquid/gas.</rdfs:comment>
  </AtomicAction>
  <PolymerType rdf:ID="DNA">
    <rdf:type rdf:resource="#MaterialType"/>
    <rdfs:comment>Deoxyribonucleic acid.</rdfs:comment>
  </PolymerType>
  <TimeUnit rdf:ID="years">
    <rdfs:comment>365 days, time unit</rdfs:comment>
  </TimeUnit>
  <DiseaseState rdf:ID="UMLS">
    <rdfs:comment>Database resource, unified medical language system, an ontology constructed by  merging several disparate ontologies, available from NIH.</rdfs:comment>
  </DiseaseState>
  <MassUnit rdf:ID="mg"/>
  <FamilyRelationship rdf:ID="uncle">
    <rdfs:comment>The brother of one's father or mother.</rdfs:comment>
  </FamilyRelationship>
  <ReplicateDescriptionType rdf:ID="biological_replicate">
    <rdfs:comment>A replicate that consists of independent biological replicates made from different individual BioSources.</rdfs:comment>
    <rdf:type rdf:resource="#QualityControlDescriptionType"/>
  </ReplicateDescriptionType>
  <BiologicalProperty rdf:ID="organism_part_comparison_design">
    <rdfs:comment>An organism part comparison experiment design type compares tissues, regions, organs within or between organisms </rdfs:comment>
  </BiologicalProperty>
  <BioMaterialCharacteristicCategory rdf:ID="organism_part">
    <rdf:type rdf:resource="#MaterialType"/>
    <rdfs:comment>The part of the organism's anatomy from which the biomaterial was derived, excludes cells. E.g. tissue, organ, system, or body location (arm).</rdfs:comment>
  </BioMaterialCharacteristicCategory>
  <TheoreticalBioSequenceType rdf:ID="rRNA_gene"/>
  <NormalizationDescriptionType rdf:ID="linlog_normalization">
    <rdfs:comment>A transformation method in which low intensities are linearly scaled while high intensities  are logarithmically scaled.  The transition point is determined by minimizing the absolute  deviation of the variance of log ratios.</rdfs:comment>
  </NormalizationDescriptionType>
  <NormalizationDescriptionType rdf:ID="iterative_mean_log_centering">
    <rdfs:comment>A method of re-scaling ratio data by subtracting the mean log base 2 ratio from each  log2(ratio).  This adjusts the mean log2(ratio) to zero.</rdfs:comment>
  </NormalizationDescriptionType>
  <DefectType rdf:ID="displaced_feature_or_zone">
    <rdfs:comment> The Feature or Zone is displaced from its expected position, due to e.g. a bent spotting pin(s).</rdfs:comment>
  </DefectType>
  <DeliveryMethod rdf:ID="subcutaneous">
    <rdfs:comment>Delivery method whereby a drug or compound is administered under the skin of the organism.</rdfs:comment>
  </DeliveryMethod>
  <TheoreticalBioSequenceType rdf:ID="snRNA_gene"/>
  <ImageFormat rdf:ID="GIF"/>
  <AtomicAction rdf:ID="dilute">
    <rdfs:comment>Decreasing the concentration of solutes in a solution or suspension.  </rdfs:comment>
  </AtomicAction>
  <ComplexAction rdf:ID="incubate">
    <rdfs:comment>The procedure of placing a physical object under specified conditions e.g. time, temperature, humidity for the purposes of obtaining a different product.</rdfs:comment>
    <rdf:type rdf:resource="#ProtocolType"/>
  </ComplexAction>
  <PhysicalBioSequenceType rdf:ID="cDNA_clone"/>
  <OrganismPartDatabase rdf:ID="CellML">
    <rdfs:comment>Ontology describing anatomical and physiological relationships. </rdfs:comment>
    <has_URI rdf:resource="#http___portal.bioengineering.elyt.ods.org_ontology_"/>
  </OrganismPartDatabase>
  <ProtocolType rdf:ID="specified_biomaterial_action">
    <rdf:type rdf:resource="#AtomicAction"/>
    <rdfs:comment>Conceptual action for specified protocol applied in treatment.</rdfs:comment>
    <rdf:type rdf:resource="#ComplexAction"/>
  </ProtocolType>
  <DatabaseEntryType rdf:ID="pedigree_record">
    <rdfs:comment>A record which descibes and identifies a pedigree or lineage for a strain, line,individal or cell whose lineage traceable e.g. a wormbase cell lineage record, or a pedigree record for a mouse</rdfs:comment>
  </DatabaseEntryType>
  <WarningType rdf:ID="not_sequence_verified">
    <rdfs:comment>The sequence of the BioSequence that relates to this reporter has not been sequence verified by the experimenter.</rdfs:comment>
  </WarningType>
  <BioSourceType rdf:ID="agar_stab">
    <rdfs:comment>agar stab, a cell culture inoculated into agar for long term storage</rdfs:comment>
  </BioSourceType>
  <NodeValueType rdf:ID="uncentered_Pearson_correlation"/>
  <DeliveryMethod rdf:ID="oral_gavage">
    <rdfs:comment>delivery method for drug or compound whereby the drug is administered via the mouth</rdfs:comment>
  </DeliveryMethod>
  <DerivedBioAssayType rdf:ID="bioassay_replicate_reduction">
    <rdfs:comment>results of data reduction involving computation of a representative value, e.g. by averaging, for a group of replicated Features, Reporters or CompositeSequences from 2 or more hybridizations.</rdfs:comment>
  </DerivedBioAssayType>
  <QuantityUnit rdf:ID="amol">
    <rdfs:comment>attomole, quantity unit</rdfs:comment>
  </QuantityUnit>
  <MaterialType rdf:ID="cytoplasmic_RNA">
    <rdfs:comment>RNA obtained from the cytoplasm.</rdfs:comment>
  </MaterialType>
  <ConcentrationUnit rdf:ID="mL_L"/>
  <TemperatureUnit rdf:ID="degrees_C">
    <rdfs:comment>degrees celsius, unit of temperature</rdfs:comment>
  </TemperatureUnit>
  <MethodologicalDesign rdf:ID="quality_control_testing_design">
    <rdfs:comment>A  quality control testing experiment design type is where some aspect of the experiment is quality controlled for the purposes of quality assurance </rdfs:comment>
  </MethodologicalDesign>
  <HardwareType rdf:ID="vortexer">
    <rdfs:comment>An instrument that mixes by rapid oscillation.</rdfs:comment>
  </HardwareType>
  <Roles rdf:ID="consultant">
    <rdfs:comment>A contact who provides some service related to some aspect of the experiment which is not data coding or analysis. E.g. help with an experimental design.</rdfs:comment>
  </Roles>
  <PhysicalBioSequenceType rdf:ID="BAC"/>
  <AtomicAction rdf:ID="wait">
    <rdfs:comment>Allow time to pass. It's measurement should be a unit of time.  </rdfs:comment>
  </AtomicAction>
  <DatabaseEntryType rdf:ID="biological_resource_record">
    <rdfs:comment>A record which describes and identifies a biological resource such as a cone or strain e.g. an ATCC record Jax strain list</rdfs:comment>
  </DatabaseEntryType>
  <BioSourceType rdf:ID="paraffin_sample">
    <rdfs:comment>A biomaterial obtained embedded in paraffin (wax).</rdfs:comment>
  </BioSourceType>
  <PublicationType rdf:ID="online_resource">
    <rdfs:comment>A publication type which is available online and which is not an online journal article, e.g. a web site or service.</rdfs:comment>
  </PublicationType>
  <OrganismPartDatabase rdf:ID="Adult_Mouse_Anatomy">
    <rdfs:comment>This ontology describes the anatomy of the adult mouse. It contains anatomical structures for the postnatal mouse (Theiler stage 28).</rdfs:comment>
    <has_URI rdf:resource="#http___www.geneontology.org_gobo_anatomy.ontology_adult_mouse_anatomy"/>
  </OrganismPartDatabase>
  <DeliveryMethod rdf:ID="feeding">
    <rdfs:comment>Delivery method where a compound/drug is administered in food or water.</rdfs:comment>
  </DeliveryMethod>
  <DerivedBioAssayType rdf:ID="normalized_intensities">
    <rdfs:comment>intensities from one or both channels resulting from normalization of MeasuredBioAssayData.</rdfs:comment>
  </DerivedBioAssayType>
  <TechnologyType rdf:ID="spotted_protein_features">
    <rdfs:comment>TechnologyType of FeatureGroup where protein (other than antibody) is spotted directly.</rdfs:comment>
  </TechnologyType>
  <ProtocolType rdf:ID="linear_amplification">
    <rdf:type rdf:resource="#ComplexAction"/>
  </ProtocolType>
  <ConcentrationUnitOther rdf:ID="x_times_"/>
  <QuantityUnit rdf:ID="mol">
    <rdfs:comment>mole, unit of quantity</rdfs:comment>
  </QuantityUnit>
  <Sex rdf:ID="unknown_sex">
    <rdfs:comment>organism(s) whose sex is unknown</rdfs:comment>
  </Sex>
  <ChromosomalAberrationClassification rdf:ID="chromosomal_duplication">
    <rdfs:comment>An irregularity in the number of chromosomes, usually in the form of a gain of genetic material.</rdfs:comment>
  </ChromosomalAberrationClassification>
  <ImageFormat rdf:ID="PNG">
    <rdfs:comment>Portable Network Graphic, a lossless image data format.</rdfs:comment>
  </ImageFormat>
  <SoftwareType rdf:ID="image_acquisition_software"/>
</rdf:RDF>
